Review
Immunology
Shelley Bhattacharya, Chayan Munshi
Summary: C-reactive protein (CRP) is an important member of the acute phase protein family and has its origin in the animal kingdom. CRP plays a key role in inflammation and immune diseases, with functions including complement activation, phagocytosis, and regulation of cytokine production. The structure of CRP shows some relatedness among different species, while invertebrates rely on the multifunctionality of CRP for evolutionary success.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tal Levinson, Eugene Feigin, Shlomo Berliner, Shani Shenhar-Tsarfaty, Itzhak Shapira, Ori Rogowski, David Zeltzer, Ilana Goldiner, Moshe Shtark, Malka Katz Shalhav, Asaf Wasserman
Summary: This study found that ferritin levels do not rise as expected in acute bacterial infections, indicating a deficiency in ferritin response to the bacterial inflammatory process. Comparison of C-reactive protein (CRP) and ferritin levels showed that ferritin levels were relatively low. This suggests that CRP and ferritin may utilize different pathways in acute phase response, resulting in a failure to increase ferritin concentrations in a state of hyperinflammation. This new entity of normoferremic inflammation serves as a new inflammatory stamp for acute bacterial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Irfan Ullah, Hashir Ali Awan, Alifiya Aamir, Mufaddal Najmuddin Diwan, Renato de Filippis, Sana Awan, Muhammad Irfan, Michele Fornaro, Antonio Ventriglio, Federica Vellante, Mauro Pettorruso, Giovanni Martinotti, Massimo Di Giannantonio, Domenico De Berardis
Summary: Schizophrenia is a major psychotic disorder affecting nearly 23.6 million people globally. Multiple risk factors, including genetic, environmental, and epigenetic factors, have been identified, with inflammation playing a significant role in the development of schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Farivar Fathian, Rolf Gjestad, Rune A. Kroken, Else-Marie Loberg, Solveig Klaebo Reitan, W. Wolfgang Fleichhacker, Maria Rettenbacher, Tor K. Larsen, Inge Joa, Lena Antonsen Stabell, Eirik Kjelby, Igne Sinkevicute, Renata Alisauskiene, Vidar M. Steen, Erik Johnsen
Summary: This study examined the effects of amisulpride, aripiprazole, and olanzapine on CRP levels in patients with schizophrenia spectrum disorder. The results showed that these drugs have different effects on CRP levels, which are also modified by previous antipsychotic exposure.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Multidisciplinary Sciences
Miyeun Han, Hye Won Lee, Han Cheol Lee, Hyo Jin Kim, Eun Young Seong, Sang Heon Song
Summary: The study found that a low Onodera's prognostic nutritional index (PNI) was associated with acute kidney injury and mortality following PCI, potentially impacting patient survival rates.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Dandan Wang, Yewei Wang, Yan Chen, Lingfang Yu, Zenan Wu, Ruimei Liu, Juanjuan Ren, Xinyu Fang, Chen Zhang
Summary: This study aimed to compare the differences in cognitive functioning and inflammatory cytokine levels among different types of schizophrenia patients and healthy controls. The results showed that deficit schizophrenia patients had worse cognitive performance and higher levels of certain inflammatory cytokines compared to nondeficit schizophrenia patients and healthy controls. These findings suggest that deficit syndrome may be an independent endophenotype of schizophrenia with unique immune-inflammatory features.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Meijuan Li, Yuying Qiu, Jing Zhang, Yonghui Zhang, Ying Liu, Yongping Zhao, Qiong Jia, Xiaoduo Fan, Jie Li
Summary: The upregulation of immune and inflammatory response may contribute to the negative symptoms of schizophrenia. Berberine, an effective drug with anti-inflammatory properties, may be beneficial for treating these symptoms. A clinical trial was conducted to test this hypothesis, with eligible schizophrenia patients randomized to receive either placebo or 900 mg/day of berberine for 8 weeks as adjunctive treatment. The results showed that berberine treatment significantly improved negative symptoms and decreased plasma CRP levels, suggesting a potential anti-inflammatory effect. This study highlights the importance of exploring new treatment approaches for schizophrenia.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Immunology
Mary Tetteh, Otchere Addai-Mensah, Zakaria Siedu, Eric Kyei-Baafour, Helena Lamptey, Jovis Williams, Edward Kupeh, Godfred Egbi, Anna Boadi Kwayie, Gabriel Abbam, David Amoah Afrifah, Alexander Yaw Debrah, Michael Fokuo Ofori
Summary: This study aimed to evaluate changes in acute phase proteins (APPs) and full blood count (FBC) indices of HbAA and HbAS children during Plasmodium falciparum infection. The results showed significant differences in APPs between HbAA and HbAS children during malaria, indicating that HbAS genotype may be associated with better control of P. falciparum infection-induced inflammatory response.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pediatrics
Yoel Gofin, Eliana Fanous, Yehonatan Pasternak, Zafnat Prokocimer, Orna Zagoory-Sharon, Ruth Feldman, Gabriel Codick, Orith Waisbourd-Zinman, Sophia Fried, Gilat Livni
Summary: The study evaluated the correlation between salivary C-reactive protein (CRP) and its serum counterpart in pediatric acute respiratory infections. Salivary CRP showed high specificity in predicting elevated serum levels without venipuncture, but higher sensitivity rates need further study.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Psychiatry
Jingfeng Su, Xia Feng, Kaiyuan Chen, Zeman Fang, Handi Zhang
Summary: This study found that the plasma level of C4 is increased in schizophrenia patients at the acute stage of illness and can be decreased by antipsychotic medication.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Hiroyoshi Takeuchi, Kei Watabe
Summary: This study aimed to examine symptom changes during short-term discontinuation of antipsychotics up to 3 weeks in patients with acute schizophrenia. The results showed that symptom severity did not worsen significantly during this discontinuation phase, supporting the once-daily dosing regimen of antipsychotics and abrupt discontinuation when switching to another antipsychotic.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Multidisciplinary Sciences
Rania Moustafa, Taissir Albouni, Ghassan Aziz
Summary: This study compared the roles of PCT and PSPN with CRP in infectious complications in acute leukemia patients. The results showed higher values of PCT and PSPN in infected patients, with PCT being the most accurate in determining infection.
Article
Multidisciplinary Sciences
Xia-Xia Jin, Mei-Dan Fang, Ling-Ling Hu, Yuan Yuan, Jiu-Fei Xu, Guo-Guang Lu, Tao Li
Summary: This study found that higher LDH levels are independently associated with poor prognosis and all-cause death in patients with acute ischemic stroke (AIS).
Article
Medicine, General & Internal
Sidharth Shankar, Shiva Manjunath, Saad Mohammad Alqahtani, Kiran Kumar Ganji, Raghavendra Reddy Nagate, Shankar T. T. Ghokale, Anil Kumar Nagarajappa, Mukhatar Ahmed Javali, Shreyas Tikare, Mohasin Abdul Khader
Summary: This study aimed to measure serum C-reactive protein (CRP) levels in individuals with periodontal health and explore the association between serum CRP levels and chronic periodontitis, and the impact of scaling and root planing (SRP) on serum CRP levels. The study included 100 systemically healthy adults who were divided into two groups: a control group of periodontally healthy subjects and a test group of subjects with chronic periodontitis. The results showed that chronic periodontitis increased blood levels of CRP, which were reduced after periodontal treatment with SRP.
Article
Clinical Neurology
Marcos Gomez-Revuelta, Jose Maria Pelayo-Teran, Javier Vazquez-Bourgon, Victor Ortiz-Garcia de la Foz, Jacqueline Mayoral-van Son, Rosa Ayesa-Arriola, Benedicto Crespo-Facorro
Summary: This study compared the effectiveness of aripiprazole and risperidone in the acute-phase treatment of FEP and found no differences in treatment discontinuation rates and mean time until discontinuation between the two drugs. However, risperidone showed better performance in terms of clinical efficacy, but patients on risperidone were more likely to experience sex-related adverse events.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)