Journal
ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING
Volume 5, Issue 5, Pages 804-810Publisher
WILEY
DOI: 10.1002/apj.398
Keywords
Alginate; calcium-induced gelation; water-soluble drug; drug release; kinetics
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Funding
- Monash Research Graduate School (MRGS)
- Australian Government
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Calcium alginate beads were prepared by ionotropic gelation of droplet of an alginate solution containing Vitamin B-12, followed by oven air drying at 70 degrees C. The beads were characterized by a light microscope and in vitro drug release in phosphate buffer saline (PBS) solution (pH 7.4) maintained at 37 degrees C in order to simulate intestinal fluid conditions. The effect of drug configuration within a bead, various process factors on the bead morphology and drug release properties was investigated. The experimental results indicated that altering the polymer to drug loading ratio, alginate, Vitamin B-12 concentration and flow rates affected the Vitamin B-12 release rates. The addition of chitosan to the polymer matrix was found to have a significant impact on the rate of release, as it slowed down the release of Vitamin B-12. It has also been found that some combinations of the parameters mentioned above, thermal effects in particular, were able to create the clear wall-core structures, and it is envisaged that one can apply those combinations or at least adopt the overall trend in a more advanced equipment to achieve controlled releasing drug micro-capsules. (C) 2009 Curtin University of Technology and John Wiley & Sons, Ltd.
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