Article
Critical Care Medicine
Jad Malas, Qiudong Chen, Tao Shen, Dominic Emerson, Tyler Gunn, Dominick Megna, Pedro Catarino, Michael Nurok, Michael Bowdish, Joanna Chikwe, Susan Cheng, Joseph Ebinger, Abirami Kumaresan
Summary: This study aimed to describe the institutional experience with extremely prolonged venovenous extracorporeal membrane oxygenation (ECMO) support for patients with acute respiratory failure. The study found that most patients in this cohort had adult respiratory distress syndrome (ARDS) secondary to COVID-19. Prolonged ECMO support was successful in weaning patients off and enabling their recovery, with a high rate of survival.
CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Darya Rudym, Tai Pham, Craig R. Rackley, Giacomo Grasselli, Michaela Anderson, Matthew R. Baldwin, Jeremy Beitler, Cara Agerstrand, Alexis Serra, Lisle A. Winston, Desiree Bonadonna, Natalie Yip, Logan J. Emerson, Amy Dzierba, Joshua Sonett, Darryl Abrams, Niall D. Ferguson, Matthew Bacchetta, Matthieu Schmidt, Daniel Brodie
Summary: This study investigated the association between obesity and mortality in patients with ARDS receiving ECMO. The results showed that patients with obesity had lower ICU mortality than patients without obesity, supporting the idea that obesity should not be considered a general contraindication to ECMO.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Critical Care Medicine
Ricardo Teijeiro-Paradis, Whitney D. Gannon, Eddy Fan
Summary: This narrative review discusses the various complications that can occur during treatment with venovenous extracorporeal membrane oxygenation (V-V ECMO), including both short-term and long-term complications. Patient selection, timing of initiation, and management decisions greatly influence the presence and severity of these potential harms.
CRITICAL CARE MEDICINE
(2022)
Article
Surgery
Perisa Ruhi-Williams, Baolin Wu, Jeffry Nahmias, Fabio Sagebin, Reza Fazl Alizadeh, Kishore M. Gadde, Alpesh Amin, Ninh T. Nguyen
Summary: This study analyzed the characteristics and outcomes of veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) due to COVID-19 versus non-COVID causes. The results showed that patients with COVID-19 ARDS requiring V-V ECMO support had higher in-hospital mortality, longer length of stay, and higher direct hospitalization cost compared to non-COVID etiologies.
Article
Cardiac & Cardiovascular Systems
J. W. Awori Hayanga, Subhasis Chatterjee, Bo Soo Kim, HelenMari Merritt-Genore, Rita Carrie Karianna Milewski, Jonathan W. Haft, Rakesh C. Arora
Summary: The high transmissibility of SARS-CoV-2 and severity of COVID-19 have created a global health emergency. The virus enters host cells through the spike membrane protein, with angiotensin-converting enzyme 2 as the receptor. The pandemic has tested the global health infrastructure and led to the exploration of new strategies. ECMO has been used as a rescue option, but there is no consensus on a specific scoring system for its severity assessment.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Critical Care Medicine
Michael Kouch, Adam Green, Emily Damuth, Christopher Noel, Jason Bartock, Michael Rosenbloom, Christa Schorr, Robert Rios, Nancy Loperfido, Nitin Puri
Summary: This study compared the effectiveness of cardiothoracic surgeons and medical intensivists in performing extracorporeal membrane oxygenation cannulation. The results showed that there was no difference in success and complication rates between the two groups in an established extracorporeal membrane oxygenation program. A rapidly deployed cannulation program led by intensivists for venovenous extracorporeal membrane oxygenation can be performed with high success and low complication rates.
CRITICAL CARE MEDICINE
(2022)
Article
Health Care Sciences & Services
Jan Naar, Andreas Kruger, Dagmar Vondrakova, Marek Janotka, Jan Kubele, Robert Lischke, Milena Kolarova, Petr Neuzil, Petr Ostadal
Summary: This case report highlights the use of prolonged VV-ECMO therapy as a bridge to lung transplantation in severe COVID-19 cases, despite numerous infectious complications. The patient in this case experienced multiple superinfections and required antimicrobial treatment for an extended period before undergoing a successful lung transplantation after 207 days of VV-ECMO support.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Respiratory System
Nam Eun Kim, Ala Woo, Song Yee Kim, Ah Young Leem, Youngmok Park, Se Hyun Kwak, Seung Hyun Yong, Kyungsoo Chung, Moo Suk Park, Young Sam Kim, Ha Eun Kim, Jin Gu Lee, Hyo Chae Paik, Su Hwan Lee
Summary: In patients awaiting lung transplantation, awake ECMO strategy leads to better post-operative outcomes than non-awake ECMO strategy, with shorter ICU stay, longer ventilator free days, higher gait ability, and improved lung function at 6 months and 1 year. Additionally, awake ECMO group has lower mortality rates at 6 months and 1 year compared to non-awake group.
RESPIRATORY RESEARCH
(2021)
Article
Critical Care Medicine
Oliver Hunsicker, Lukas Beck, Alexander Krannich, Tobias Finger, Vincent Prinz, Claudia Spies, Steffen Weber-Carstens, Stefan Wolf, Jan Adriaan Graw, Mario Menk
Summary: Intracranial hemorrhage is a serious complication in patients receiving venovenous extracorporeal membrane oxygenation during treatment of the acute respiratory distress syndrome. The study found that early occurrence of intracranial hemorrhage is associated with higher 60-day mortality, and adjusting modifiable risk factors may lower the prevalence of this complication.
CRITICAL CARE MEDICINE
(2021)
Article
Respiratory System
Christian Lang, Valentin Ritschl, Florian Augustin, Gyoergy Lang, Bernhard Moser, Shahrokh Taghavi, Gabriella Murakoezy, Christopher Lambers, Holger Flick, Markus Koestenberger, Roxane Brooks, Tina Muhr, Johann Knotzer, Daniel Mydza, Marc Kaufmann, Thomas Staudinger, Christian Zauner, Claus Krenn, Eva Schaden, Andreas Bacher, Bernhard Roessler, Peter Faybik, Edda Tschernko, Maria Anwar, Klaus Markstaller, Daniel Honefer, Tanja Stamm, Peter Jaksch, Konrad Hoetzenecker
Summary: This study analyzed the situation and outcomes of patients with severe ARDS caused by COVID-19 who required lung transplantation in Austria. The results showed that early referral of ECMO patients to a lung transplantation center is crucial, and transplantation can achieve good midterm outcomes in the treatment of post-COVID-19 ARDS.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Ting-Yu Liao, Sheng-Yuan Ruan, Chien-Heng Lai, Li-Jung Tseng, Li-Ta Keng, You-Yi Chen, Chih-Hsien Wang, Jung-Yien Chien, Huey-Dong Wu, Yih-Sharng Chen, Chong-Jen Yu
Summary: This study aimed to investigate the impact of ventilator settings on patient outcomes in influenza-associated ARDS patients receiving vv-ECMO support. The results showed that a higher respiratory rate was associated with higher mortality. Therefore, adjusting the respiratory rate may improve outcomes in this patient population.
Article
Pediatrics
Yucai Zhang, Chunxia Wang, Fei Wang, Jingyi Shi, Jiaying Dou, Yijun Shan, Ting Sun, Yiping Zhou
Summary: Lung ultrasound score is a promising tool for predicting the prognosis in patients with ARDS under ECMO support. Moreover, LUS-72 h >= 24 is associated with high risk of PICU mortality in patients with pARDS who received ECMO.
FRONTIERS IN PEDIATRICS
(2022)
Review
Critical Care Medicine
Wynne Hsing Poon, Kollengode Ramanathan, Ryan Ruiyang Ling, Isabelle Xiaorui Yang, Chuen Seng Tan, Matthieu Schmidt, Kiran Shekar
Summary: Prone positioning during VV ECMO treatment for ARDS patients can improve survival rates, but may result in longer ICU stays and ECMO durations.
Article
Respiratory System
Darryl Abrams, Purnema Madahar, Christina M. Eckhardt, Briana Short, Natalie H. Yip, Madhavi Parekh, Alexis Serra, Richard L. Dubois, Danial Saleem, Cara Agerstrand, Peter Scala, Luke Benvenuto, Selim M. Arcasoy, Joshua R. Sonett, Koji Takeda, Anne Meier, James Beck, Patrick Ryan, Eddy Fan, Carol L. Hodgson, Matthew Bacchetta, Daniel Brodie
Summary: This study aimed to identify factors associated with achieving out-of-bed physical therapy in ECMO-supported patients and assess the safety and feasibility of early mobilization with femoral cannulation. The results showed that pre-transplantation, venovenous ECMO, later cannulation year, and higher Charlson comorbidity index were associated with increased odds of achieving out-of-bed physical therapy, while invasive mechanical ventilation and femoral cannulation were associated with decreased odds. Physical therapy with femoral cannulation was safe, feasible, and had low complication rates.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Cardiac & Cardiovascular Systems
Dong Hoon Kang, Jong Woo Kim, Sung Hwan Kim, Seong Ho Moon, Jun Ho Yang, Jae Jun Jung, Ho Jeong Cha, Jun Young Choi, Chung Eun Lee, Won Heo, Sung Dae Lim, Joung Hun Byun
Summary: Serial connection of two veno-venous ECMO circuits can be beneficial when severe hypoxemia or hypercapnia are not improved and protective ventilators cannot be used.
Article
Critical Care Medicine
Theodore J. Iwashyna, James F. Burke, Jeremy B. Sussman, Hallie C. Prescott, Rodney A. Hayward, Derek C. Angus
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2015)
Editorial Material
Critical Care Medicine
Theodore J. Iwashyna, Emily C. Speelmon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2016)
Letter
Critical Care Medicine
Tara Quasim, Martin Shaw, Joanne McPeake, Martin Hughes, Theodore J. Iwashyna
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Editorial Material
Medicine, General & Internal
Anica C. Law, Gary E. Weissman, Theodore J. Iwashyna
ANNALS OF INTERNAL MEDICINE
(2020)
Article
Medicine, General & Internal
Valeria S. M. Valbuena, Sarah Seelye, Michael W. Sjoding, Thomas S. Valley, Robert P. Dickson, Steven E. Gay, Dru Claar, Hallie C. Prescott, Theodore J. Iwashyna
Summary: This study aimed to evaluate measurement discrepancies between pulse oximetry and arterial oxygen saturation among inpatients in general care settings. The results showed that black patients were more likely to have occult hypoxemia noted on arterial blood gas but not detected by pulse oximetry compared to white patients.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Nursing
Sheria G. Robinson-Lane, Amanda N. Leggett, Florence U. Johnson, Natalie Leonard, Alicia G. Carmichael, Grace Oxford, Tanbirul Miah, Johnny J. Wright, Amanda C. Blok, Theodore J. Iwashyna, Richard Gonzalez
Summary: This study aims to identify how family caregivers adapt to the caregiving role following a relative's COVID-19-related ICU hospitalization. Six themes were found, including engaging the support of family and friends, increased responsibilities, managing emotions, managing infection control, addressing patient independence, and engaging support services.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Cardiac & Cardiovascular Systems
Molly Harrod, Katrina Hauschildt, Lee A. Kamphuis, Peggy R. Korpela, Marylena Rouse, Brahmajee K. Nallamothu, Theodore J. Iwashyna
Summary: This study examined the experiences and needs of caregivers for veteran survivors of in-hospital cardiac arrest. The findings revealed that caregivers experienced disruptions in various aspects of their lives, including their own well-being, their relationships with the survivors, and their everyday routines. Additional support and resources were identified as necessary to help caregivers cope with these disruptions.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Critical Care Medicine
Jeffrey J. Presneill, Rinaldo Bellomo, Kathy Brickell, Heidi Buhr, Belinda J. Gabbe, Doug W. Gould, Meg Harrold, Alisa M. Higgins, Sally Hurford, Theodore Iwashyna, Ary Serpa Neto, Alistair Nichol, Stefan J. Schaller, Janani Sivasuthan, Claire Tipping, Steven Webb, Paul Young, Carol L. Hodgson
Summary: The TEAM III trial aims to compare the effects of early activity and mobilisation in critically ill patients. The study protocol and statistical analysis plan have been developed to ensure unbiased analysis of the collected clinical data.
CRITICAL CARE AND RESUSCITATION
(2021)
Article
Respiratory System
Hallie C. Prescottt, Theodore J. Iwashyna
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2019)
Article
Respiratory System
Hallie C. Prescott, Alicia G. Carmichael, Kenneth M. Langa, Richard Gonzalez, Theodore J. Iwashyna
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2019)
Article
Health Care Sciences & Services
Brenda M. Vincent, Wyndy L. Wiitala, Jennifer A. Burns, Theodore J. Iwashyna, Hallie C. Prescott
HEALTH SERVICES AND OUTCOMES RESEARCH METHODOLOGY
(2018)
Article
Respiratory System
Rachel A. Bucy, Kaitlyn A. Hanisko, Lee A. Kamphuis, Brahmajee K. Nallamothu, Theodore J. Iwashyna, Paul N. Pfeiffer
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2017)
Article
Respiratory System
Giora Netzer, Theodore J. Iwashyna
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2017)
Article
Respiratory System
Joanna L. Spencer-Segal, Robert C. Hyzy, Theodore J. Iwashyna, Theodore J. Standiford
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2017)
Editorial Material
Respiratory System
Theodore J. Iwashyna, Kimberley J. Haines
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2016)