Article
Food Science & Technology
Manon Ebersolt, Tacy Santana Machado, Cecilia Mallmann, Nathalie Mc-Kay, Laetitia Dou, Dammar Bouchouareb, Philippe Brunet, Stephane Burtey, Marion Sallee
Summary: A low protein/fiber index is associated with lower concentrations of uremic toxins in anuric hemodialysis patients. Diets with increased fiber intake should be tested to determine if they can reduce serum concentrations of p-cresyl sulfate and indoxyl sulfate.
Article
Cell Biology
Jung Sun Park, Dong-Hyun Kim, Hoon-In Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Summary: This study investigated the effects of uremic toxins on ferroptosis in the kidney, finding that protein-bound uremic toxins can induce ferroptosis and result in cell death.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Robson E. Silva, Eliziaria C. Santos, Patricia B. Justino, Margarida P. Santos, Giovane Galdino, Reggiani Goncalves, Romulo D. Novaes
Summary: The relationship between dialysis adequacy and circulating levels of inflammatory mediators was investigated, showing that low Kt/V results and creatinine accumulation may serve as potential indicators of systemic inflammatory stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Kullaya Takkavatakarn, Pongpratch Puapatanakul, Jeerath Phannajit, Warumphon Sukkumme, Pajaree Chariyavilaskul, Patita Sitticharoenchai, Asada Leelahavanichkul, Pisut Katavetin, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong
Summary: Sevelamer therapy was more effective than calcium carbonate therapy in reducing the protein-bound uremic toxin p-cresyl sulfate. Sevelamer also helped lower fibroblast growth factor 23 and low-density lipoprotein cholesterol levels, showing benefits in terms of retarding CKD progression. No changes in vascular stiffness were found in this study.
Article
Cardiac & Cardiovascular Systems
Bert Zwaenepoel, Tine De Backer, Griet Glorieux, Francis Verbeke
Summary: This study evaluated the association between plasma protein-bound uremic toxins concentrations, echocardiographic parameters of heart failure, and incident heart failure events in chronic kidney disease patients not on dialysis. The results showed that elevated free concentrations of indoxyl sulfate, p-cresyl glucuronide, and p-cresyl sulfate were independently associated with an increased risk of heart failure events in these patients.
Article
Biochemistry & Molecular Biology
Theodoros Tourountzis, Georgios Lioulios, Steven Van Laecke, Evdoxia Ginikopoulou, Vasiliki Nikolaidou, Eleni Moysidou, Stamatia Stai, Michalis Christodoulou, Asimina Fylaktou, Griet Glorieux, Maria Stangou
Summary: Increased levels of PBUTs in patients on hemodialysis are associated with immune disturbances, with HA and IxS being related to immunosenescence and pCS to immune exhaustion.
Article
Biochemistry & Molecular Biology
Sevigean Ali, Mihaela Botnarciuc, Lavinia Carmen Daba, Sorina Ispas, Alina Mihaela Stanigut, Camelia Pana, Marian-Catalin Burcila, Liliana-Ana Tuta
Summary: There is limited research on decreased platelet count in chronic kidney disease (CKD), but platelet functions are altered in the uremic environment, leading to an increased risk of bleeding. This study monitored 104 CKD patients with thrombocytopenia who received platelet transfusion and evaluated their prognosis. The results showed that in patients with multiple comorbidities, 4.83% still experienced severe uncontrolled hemorrhages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Urology & Nephrology
Kullaya Takkavatakarn, Thunyatorn Wuttiputinun, Jeerath Phannajit, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong
Summary: Prebiotics, synbiotics, and AST-120 were found to effectively reduce both serum indoxyl sulfate and p-cresyl sulfate levels in CKD patients compared to placebo. Preservation of residual renal function was associated with lower levels of these protein-bound uremic toxins. The effectiveness of biotic supplements was only observed in dialysis patients. Further studies are needed to evaluate the efficacy in non-dialysis CKD patients due to limited data.
JOURNAL OF NEPHROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vida Dehghan Niestanak, Larry D. Unsworth
Summary: Chronic kidney disease is a major cause of mortality, characterized by the gradual progression of kidney dysfunction and accumulation of protein-bound uremic toxins (PBUTs) in the bloodstream. The inadequate effectiveness of conventional treatments, such as hemodialysis, in clearing PBUTs highlights the importance of studying how these toxins bind to blood proteins. This study gathered data on the binding of various PBUTs to human serum albumin and reviewed common techniques used to investigate the thermodynamics and structure of the PBUT-albumin interaction, providing valuable insights for improving toxin clearance through dialysis or designing better adsorbents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Urology & Nephrology
Laetitia Koppe, Christophe O. Soulage
Summary: Chronic kidney disease is associated with changes in the gut microbiota, and diet plays a crucial role in managing the disease. This review discusses the latest research on the interactions between diet and gut microbiota in the context of uremia, and how this knowledge can be used to develop personalized nutrition strategies to prevent the progression of chronic kidney disease to kidney failure and its complications.
KIDNEY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Yuji Oe, Nobuyuki Takahashi
Summary: Coagulation abnormalities are common in chronic kidney disease (CKD). Tissue factor plays a key role in promoting coagulation and inflammation, exacerbating renal injury.
Review
Food Science & Technology
Mara Lauriola, Ricard Farre, Pieter Evenepoel, Saskia Adriana Overbeek, Bjorn Meijers
Summary: Patients with CKD have a higher cardiovascular risk than the general population due to the accumulation of uremic toxins. Protein-bound uremic toxins originate from various sources and are difficult to remove with conventional therapies. Diet plays an important role in uremic toxicity, with most toxins derived from the gut. This review summarizes the sources of uremic toxins in foods and discusses their metabolism and potential dietary strategies for reducing their plasma levels.
Article
Endocrinology & Metabolism
Nagarjunachary Ragi, Pavankumar Pallerla, Aravind Reddy Babi Reddy Gari, Sai Sachin Lingampelly, Vijayasarathy Ketavarapu, Ramunaidu Addipilli, Nagaraju Chirra, Srinivas Kantevari, Manjusha Yadla, Prabhakar Sripadi
Summary: This study aimed to identify and quantify major uremic toxins in chronic kidney disease (CKD) patients on maintenance hemodialysis (HD) from an Indian perspective. The results revealed the presence of various known and unknown uremic toxins in pre-HD patients, with p-cresol sulfate and indoxyl sulfate being the dominant ones. The dialytic clearance of these two toxins was less than 35%, while the clearance of the other three sulfates ranged from 50-58%.
Review
Food Science & Technology
Mateo Ondrussek-Sekac, Diana Navas-Carrillo, Esteban Orenes-Pinero
Summary: In chronic kidney disease, dysbiosis of intestinal microbiota can lead to uremic toxicity, inflammation and disease progression. Modulating gut microbiota through dietary changes and using probiotics, prebiotics, and low protein diets can offer therapeutic interventions to improve this imbalance and manage chronic kidney disease effectively.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Sabbir Ahmed, Joost C. de Vries, Jingyi Lu, Milan H. Verrijn Stuart, Silvia M. Mihaila, Robin W. M. Vernooij, Rosalinde Masereeuw, Karin G. F. Gerritsen
Summary: Protein-bound uremic toxins (PBUTs) are associated with the progression of chronic kidney disease (CKD) and its associated morbidity and mortality. Conventional dialysis techniques are not efficient in removing PBUTs due to their plasma protein binding. Therefore, novel approaches are being developed and validated in animal models before clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
M. van der Giet
Summary: Arterial hypertension is a global burden with high prevalence, and while many pharmaceutical approaches have been developed for treating it, no novel medications are currently in sight. Interventional procedures like renal denervation have been extensively researched as alternatives.
Article
Peripheral Vascular Disease
George S. Stergiou, Paolo Palatini, Gianfranco Parati, Eoin O'Brien, Andrzej Januszewicz, Empar Lurbe, Alexandre Persu, Giuseppe Mancia, Reinhold Kreutz
Summary: The collaborators come from different countries and regions, representing experts in the field of hypertension research, working together to make contributions.
JOURNAL OF HYPERTENSION
(2021)
Article
Anesthesiology
Isabell A. Just, Farnoush Alborzi, Maren Godde, Sascha Ott, Alexander Meyer, Julia Stein, Stefan Mazgareanu, Markus van der Giet, Kai M. Schmidt-Ott, Volkmar Falk, Felix Schoenrath
Summary: This study aimed to investigate the risk factors and typical clinical course of cardiac surgery-associated acute kidney injury (CS-AKI) and derive strategies for perioperative clinical routines. The results showed that close monitoring of renal function for at least 72 hours after cardiac surgery is crucial, especially in patients with preexisting chronic kidney disease (CKD) and signs of CS-AKI. Renal protective strategies should be initiated early to prevent the onset of AKI.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Urology & Nephrology
Hans Pottel, Elke Schaeffner, Natalie Ebert, Markus van der Giet, Pierre Delanaye
Summary: The fitting procedure has a significant impact on the precision of calculated AUC and GFR. The simplified late-sample protocols and one-sample methods are not affected by fitting issues and show acceptable equivalence to the full compartment GFR results.
Article
Biochemistry & Molecular Biology
Mirjam Schuchardt, Jaqueline Herrmann, Cornelia Henkel, Milen Babic, Markus van der Giet, Markus Toelle
Summary: AZA treatment may induce vascular smooth muscle cell calcification, increasing the risk of cardiovascular disease. The study suggests that the mechanism of action may be related to the NLRP3 inflammasome.
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Horst Sievert, Stefan Bertog, Lucas Lauder, Sebastian Ewen, Jean-Philippe Lengele, Wojciech Wojakowski, Roland Schmieder, Markus van der Giet, Michael A. Weber, David E. Kandzari, Helen Parise, Tim A. Fischell, Atul Pathak, Alexandre Persu
Summary: Catheter-based chemical renal denervation with dehydrated alcohol using the Peregrine Catheter appears to safely reduce blood pressure at a 12-month follow-up. There were no major procedural complications, and changes in blood pressure were observed in both ambulatory and office settings. Further randomized and sham controlled studies are needed to confirm these findings.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Medicine, General & Internal
Josephine L. C. Anderson, Markus van Der Giet, Antonio W. Gomes Neto, Stephan J. L. Bakker, Uwe J. F. Tietge
Summary: This study found that statin use does not significantly decrease cardiovascular events in renal transplant recipients overall. However, in patients using cyclosporine, statin use is independently associated with an increased risk of cardiovascular events and cardiovascular-specific mortality, possibly due to a pharmacological interaction.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Public, Environmental & Occupational Health
K. Fehrenbacher, C. Apel, D. Bertsch, M. S. van der Giet, S. van der Giet, M. Grass, C. Gschwandtl, N. Heussen, N. Hundt, C. Kuehn, A. Morrison, M. Mueller-Ost, M. Mueller-Tarpet, S. Porath, J. Risse, S. Schmitz, V Schoeffl, L. Timmermann, K. Wernitz, T. Kuepper
Summary: White noise exposure at high altitude poses a higher risk for noise-induced hearing loss, despite acclimatization increasing arterial oxygen saturation, it does not offer sufficient protection for the inner ear. Therefore, protective devices are recommended at altitudes above 1500 meters when noise levels exceed 75 dB, and should be used definitively above 80 dB to consider individual reactions to hypobaric hypoxia at high altitude.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2021)
Article
Medicine, General & Internal
Bertram Pitt, Gerasimos Filippatos, Rajiv Agarwal, Stefan D. Anker, George L. Bakris, Peter Rossing, Amer Joseph, Peter Kolkhof, Christina Nowack, Patrick Schloemer, Luis M. Ruilope
Summary: Finerenone therapy improved cardiovascular outcomes in patients with type 2 diabetes and stage 2 to 4 CKD with moderately elevated albuminuria or stage 1 or 2 CKD with severely elevated albuminuria, compared to placebo. The risk of the primary outcome event was significantly lower in the finerenone group, primarily driven by a reduction in hospitalization for heart failure.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Physiology
Alexander Reshetnik, Jonida Gjolli, Markus van der Giet, Friederike Compton
Summary: Invasive thermodilution techniques are still the gold standard for cardiac output measurement, but there is a growing need for non-invasive techniques to simplify the process. A novel oscillometry-based CO estimation method was evaluated and found to have some level of agreement with transpulmonary thermodilution in certain circumstances.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biology
Jaqueline Herrmann, Manasa Reddy Gummi, Mengdi Xia, Markus van der Giet, Markus Toelle, Mirjam Schuchardt
Summary: Arterial vessel diseases, particularly vascular calcification, are major contributors to cardiovascular morbidity and mortality. With various pathophysiological pathways involved, numerous rodent models and detection methods have been established for basic research. The aim is to provide an overview of available rodent models and quantification methods, emphasizing adherence to the 3R principles of replacement, reduction, and refinement.
Article
Multidisciplinary Sciences
Max Taubert, Elke Schaeffner, Peter Martus, Markus van der Giet, Uwe Fuhr, Amina Loesment, Natalie Ebert
Summary: In this study, the impact of a Bayesian estimation procedure on iohexol clearance estimates was evaluated, and an optimal sampling strategy was identified based on data in individuals aged 70+. A simplified three-compartment model was found to be optimal for estimating iohexol clearance in elderly patients with reduced GFR.
SCIENTIFIC REPORTS
(2021)
Article
Peripheral Vascular Disease
Thomas Weber, Jaques Amar, Tine de Backer, Thilo Burkard, Marcus van der Giet, Philippe Gosse, Andrzej Januszewicz, Thomas Kahan, Giuseppe Mancia, Christopher C. Mayer, Maria Lorenza Muiesan, George S. Stergiou, Konstantinos Tsioufis, Bernard Vaisse, Reinhold Kreutz
Summary: The Covid-19 pandemic led to a significant decrease in non-Covid-19 related hypertension care procedures. The first wave and lockdown period saw the largest reduction in diagnostic and therapeutic procedures related to hypertension. The long-term consequences on blood pressure control and cardiovascular events need further investigation.
Article
Medicine, Research & Experimental
Rebecca Ingenhoff, Juliet Nandawula, Trishul Siddharthan, Isaac Ssekitoleko, Richard Munana, Benjamin E. Bodnar, Ivan Weswa, Bruce J. Kirenga, Gerald Mutungi, Markus van der Giet, Robert Kalyesubula, Felix Knauf
Summary: This study aims to evaluate the effectiveness of a community health worker (CHW)-led intervention in blood pressure control among hypertensive patients in low-income and middle-income countries (LMICs). The intervention includes monthly household visits by trained CHWs for monitoring, assessment, and counseling. The results of this study will provide important information for hypertension management in LMIC settings.
Article
Genetics & Heredity
Markus Toelle, Cornelia Henkel, Jaqueline Herrmann, Christoph Daniel, Milen Babic, Mengdi Xia, Anna M. Schulz, Kerstin Amann, Markus van der Giet, Mirjam Schuchardt
Summary: This study evaluated an adenine-based uremic mouse model to study medial vessel calcification and senescence-associated secretory phenotype (SASP) changes, providing a basis for understanding molecular pathogenesis and potential therapeutic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)