Article
Integrative & Complementary Medicine
Hao Fuliang, Mei Shuang, Liu Xiao, Liu Yang, Zhang Xudong, Dong Fusheng
Summary: The study showed that icariin can promote the proliferation of osteoblasts at the site of skull defects in rabbits, accelerating bone tissue formation and repair, providing effective help for fracture healing.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2021)
Article
Medicine, General & Internal
Yiquan Wang, Shuyue Song, Zhen Li, Yujing Zhao, Junjie Miao, Zhe Wang
Summary: This case report presents a patient with type I neurofibromatosis accompanied by an occipital bone defect. The patient showed right upper limb weakness and jitter and underwent successful surgical treatment. Involvement of the skull with bone defect in neurofibromatosis type I is very rare, highlighting the importance of accumulating more cases and understanding the disease's pathogenesis for early therapeutic intervention.
Article
Biochemistry & Molecular Biology
Sabrina Livia Ng, Subhabrata Das, Yen-Peng Ting, Raymond Chung Wen Wong, Nattharee Chanchareonsook
Summary: Titanium has been widely used in osteosynthesis for decades with its compatibility and safety unquestioned. Recent studies have shown an increase in the use of 3D-printed custom titanium implants, however, the amount of titanium released from these implants is still unknown. Results from a pilot study done on rabbits indicated that the biosafety of 3D-printed titanium implants is comparable to traditionally fabricated titanium implants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Ahmed Abdelrahiem Sadek, Mahmoud Abd-Elkareem, Hani Nasser Abdelhamid, Samia Moustafa, Kamal Hussein
Summary: The UiO-66 nanomaterial demonstrates excellent cytocompatibility and stimulates osteoblast functions, indicating its potential as a biomaterial for bone tissue engineering. In vivo experiments show enhanced osteogenesis and healing of bone defects, making UiO-66 a promising candidate for bone repair.
BMC VETERINARY RESEARCH
(2022)
Article
Engineering, Biomedical
Sara Gallinetti, Lars Kihlstrom Burenstam Linder, Jonas Aberg, Christopher Illies, Hakan Engqvist, Ulrik Birgersson
Summary: In a 52 week ovine calvaria implantation model, the study found that a titanium mesh embedded in calcium phosphate (CaP) had better bone formation and osteointegration compared to a bare titanium mesh. The degradation of CaP replaced by mature bone tissue in the defect sites implanted with CaP-Ti was observed, with new bone forming mainly at the bony edges of the defect and on the dura side. Calcium-phosphate-filled macrophages were found in all animals, indicating their potential role in osteogenesis.
BIOMEDICAL MATERIALS
(2021)
Article
Engineering, Biomedical
Dong Jin Ryu, Eui Yub Jung, Da Hee Hong, Kyeu Baek Kwon, Sang Jun Park, Joo Hwan Kim, Joon Ho Wang
Summary: The article discusses the importance of bone graft in surgical procedures, explores different alternative compounds, and compares the effects of different types of BCP products on new bone formation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Tong Wang, Zhou Yu, Yajuan Song, Liu Yang, Lin Chen, Juanli Dang, Xianhui Zeng, Shuzhong Guo, Yingjun Su, Baoqiang Song
Summary: The effect of the dura mater on the integration of porous titanium implants and cranial bone was evaluated in this study. It was found that the group with intact dura mater showed significantly higher bone volume/total volume and trabecular number. Histological analysis also revealed more newly formed bone and calcification deposition in this group. These findings indicate that having an intact dura mater improves the osteogenesis and osteointegration properties of porous titanium implants.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yen-Lung Chiu, Yun-Li Luo, Yuan-Wu Chen, Chi-Tsung Wu, Srinivasan Periasamy, Ko-Chung Yen, Dar-Jen Hsieh
Summary: Bone defects can be caused by various reasons, and bone grafts are commonly used as substitutes. The use of supercritical carbon dioxide in the production of bone grafts is a new trend. An experiment combining bone graft powder and acellular dermal matrix powder in a putty material showed promising results in rabbit models, demonstrating good stickiness and cohesiveness.
Article
Biochemistry & Molecular Biology
Thanuja D. K. Herath, Leonardo Saigo, Benoit Schaller, Anis Larbi, Swee Hin Teoh, Charles James Kirkpatrick, Bee Tin Goh
Summary: This study showed that autologous neutrophils may have a positive effect on promoting new bone formation, providing potential clinical benefits for bone regeneration in oral and maxillofacial surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Xiaomei Xia, Ziyang Liu, Hongshui Wang, Xianrui Zou, Lei Zhang, Kun Qin, Jiantao Zheng, Huan Zhou, Lei Yang, Chunyong Liang
Summary: This study successfully prepared a Janus bilayer membrane with asymmetric wetting properties for repairing skull base defects caused by pituitary tumor surgery. The membrane effectively controlled cerebrospinal fluid leakage and promoted bone repair. In vitro cell experiments showed the membrane's excellent biocompatibility and capacity to promote osteogenic differentiation.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Orthopedics
Ali Ihsan Kilic, Onur Hapa, Ramadan Ozmanevra, Theresa Pak, Pinar Akokay, Bekir Ugur Ergur, Mustafa Can Kosay
Summary: This study investigated the effects of different microfracture locations on healing in a rabbit knee osteochondral defect model. The results showed better cartilage healing with microfracture performed at the peripheral margin of the defect, suggesting that interaction of pluripotent cells released from the microfracture site with the intact cartilage may enhance the quality of the repair tissue.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Orthopedics
Ali Ihsan Kilic, Onur Hapa, Ramadan Ozmanevra, Theresa Pak, Pinar Akokay, Bekir Ugur Ergur, Mustafa Can Kosay
Summary: This study investigated the effects of microfracture surgery at different locations on the healing of knee osteochondral defects in a rabbit model. The results suggest that performing microfracture at the peripheral margin of the defect improves the quality of cartilage repair.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Medicine, General & Internal
Juan Liu, Xin Qi, Xiao-Hong Wang, Hong-Sheng Miao, Zi-Chao Xue, Le-Le Zhang, San-Hu Zhao, Liang-Hao Wu, Guo-Yi Gao, Mei-Qing Lou, Cheng-Qing Yi
Summary: This study reveals the important role of MEG3 in osteogenic differentiation of BMSCs and bone regeneration, suggesting that MEG3 engineered BMSCs may be effective potential therapeutic targets for skull defects.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Physical
Lauren A. Boller, Madison A. P. McGough, Stefanie M. Shiels, Craig L. Duvall, Joseph C. Wenke, Scott A. Guelcher
Summary: Autograft (AG) is considered as the gold standard for bone grafts, but its limited quantities and patient morbidity have led to the proposal of AG extenders to minimize the volume of AG while maintaining its osteoinductive properties. This study evaluated PEUR and PTKUR AG extenders in a rabbit radius defect model and found that AG extenders supported new bone formation, with PEUR degrading more rapidly than PTKUR. It was also observed that residual polymer in the AG extenders inhibited cellular infiltration and subsequent bone formation.
Article
Multidisciplinary Sciences
Yue Wang, Xiaoyan Zhang, Shuang Mei, Yunlong Li, Anas Ameer Khan, Shuai Guan, Xiangjun Li
Summary: A rabbit model of mandibular box-shaped defects created through an intraoral approach was evaluated to determine the minimum size defect that would not spontaneously heal during the rabbit's natural life (critical-sized defect, CSD). The dimensions of the CSD were determined to be 8 mm x 3 mm x 2 mm. This model provides a clinically relevant base for future tissue engineering efforts in the mandible.
