Journal
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
Volume 30, Issue 10, Pages 2120-2124Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ja00199d
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Funding
- Cells in Motion Cluster of Excellence, Munster, Germany [CiM-EXC 1003, FF-2013-17]
- DFG [Bu 1140 / 5-1, Ho 2062 / 9-1]
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A laser ablation system (LA) was coupled to an in-house developed low-flow inductively coupled plasma ion source for mass spectrometry (ICP-MS). In this setup, the low-flow torch showed best analytical performance at a total argon gas flow rate of only 1.27 L min(-1) and a generator power of 900 W. The optimized system was applied to elemental bioimaging. Two different sections of one kidney sample were analyzed and images of the elements Al and Br from the staining agents hematoxylin and eosin, respectively, and I from a contrast agent iodixanol were recorded selectively and with high sensitivity. For detection of the elements, the mass traces Al-27, Br-79, Br-81, and I-127 were selected to demonstrate the system's analytical performance over a wide mass range. In total, the argon consumption could be reduced by >90% compared to conventional ICP-MS systems.
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