Review
Biochemistry & Molecular Biology
Bao Tran Duy Nguyen, Hai Yen Nguyen Thi, Bich Phuong Nguyen Thi, Dong-Ku Kang, Jeong E. Kim
Summary: The COVID-19 pandemic in 2020 highlighted the importance of artificial lung membrane technology, while the aging global population is leading to a higher demand for better artificial organ devices. Despite significant advancements in AO technology over the past decades, the quality of life for organ failure patients remains poor, emphasizing the need for further improvements, particularly in membrane technology. The research on membrane development for AO devices is relatively limited, likely due to the interdisciplinary nature of AO technology, ranging from biotechnology to polymer chemistry and process engineering.
Article
Engineering, Biomedical
Yansha Hao, Jingting Zhou, Ju Tan, Feng Xiang, Zhongliang Qin, Jun Yao, Gang Li, Mingcan Yang, Lingqin Zeng, Wen Zeng, Chuhong Zhu
Summary: Cross-linking agents are commonly used to restore corneal properties after decellularization, but it is crucial to select an appropriate method to prevent excessive cross-linking. Furthermore, further investigation is needed on promoting wound healing and improving scar formation.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Jarrett C. Moyer, Venkat Keshav Chivukula, Parsa Taheri-Tehrani, Sukhveer Sandhu, Charles Blaha, William H. Fissell, Shuvo Roy
Summary: This study developed a compact and cost-effective mock circulatory loop (MCL) to refine and test implantable bioartificial organs and blood-interfacing membranes. The MCL successfully replicated the flow rates and pressures consistent with pulsatile arteriovenous shunts measured in swine.
Editorial Material
Biochemical Research Methods
Madhura Mukhopadhyay
Summary: Assembloids accurately recapitulate the spatial organization and interaction of organs.
Article
Chemistry, Multidisciplinary
Fan Wang, Qinchuan Li, Jong-Oh Park, Shaohui Zheng, Eunpyo Choi
Summary: A high-performance low-cost bioartificial muscle based on functional carboxylated bacterial cellulose and polypyrrole nanoparticles has been developed, demonstrating large bending strain, long actuated bending durability, broad frequency bandwidth, fast response time, high energy density, and high power density. Various bioinspired applications have been realized, offering a viable means for developing high-performance bioartificial muscles for next-generation soft bioelectronics.
ADVANCED FUNCTIONAL MATERIALS
(2021)
News Item
Biotechnology & Applied Microbiology
Asher Mullard, Hans Clevers
Summary: Hans Clevers, the head of Pharma Research & Early Development at Roche, explores the application of organoids in drug discovery and development.
NATURE REVIEWS DRUG DISCOVERY
(2023)
Article
Medicine, Research & Experimental
Jun Weng, Xu Han, Fanhong Zeng, Yue Zhang, Lei Feng, Lei Cai, Kangyan Liang, Shusong Liu, Shao Li, Gongbo Fu, Min Zeng, Yi Gao
Summary: The study utilized a fiber scaffold bioreactor for high-density, 3D culture of porcine hepatocytes to construct a bioartificial liver and evaluated its protective effects in an ALF porcine model. The bioartificial liver treatment enhanced liver regeneration, alleviated systemic inflammatory response, and reduced extrahepatic organ injury, leading to prolonged survival in the ALF model.
Article
Biotechnology & Applied Microbiology
[Anonymous]
Summary: Recent patents about the manufacturing and utilization of organoids and organs on a chip indicate the continuous development and innovation in this field.
NATURE BIOTECHNOLOGY
(2022)
Article
Pediatrics
Kimberly A. Johnston, Christopher J. Pino, Goldia Chan, Skylar K. Ketteler, Stuart L. Goldstein, H. David Humes
Summary: This study investigated the use of a pediatric hemodialysis system for the application of SCD therapy in pigs with septic shock. The results showed that SCD therapy was safe and effective, with improved blood pressure and reduced lactic acidosis compared to conventional hemodiafiltration. The therapy also prevented renal failure and reduced neutrophil activation and organ dysfunction. This suggests that SCD therapy has the potential to be a beneficial treatment for acute kidney injury in pediatric patients.
PEDIATRIC RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Duy-Chi Trinh, Juan Alonso-Serra, Mariko Asaoka, Leia Colin, Matthieu Cortes, Alice Malivert, Shogo Takatani, Feng Zhao, Jan Traas, Christophe Trehin, Olivier Hamant
Summary: Plants produce organs with various shapes and sizes, influenced by mechanical signals such as turgor pressure and cell wall contiguity. Mechanical feedback helps in maintaining elemental shapes of plant organs and generating complex shapes. Mechanical conflicts at boundaries of domains with different growth rates contribute to the emergence of features such as folds and growth arrest in plant organs. Integration of mechanical signals with molecular networks offers potential prospects for understanding organ shape robustness and the interplay between biochemical and mechanical signals in defining cell and organ identities.
Article
Multidisciplinary Sciences
Tamara Frank, Jamie Sickles, Danielle Deleo, Patricia Blackwelder, Heather Bracken-Grissom
Summary: Many marine species use bioluminescence to counterilluminate, and recent studies have shown that deep-sea shrimps have light-sensitive photophores. Our experiments on Pesta shrimps also demonstrated photosensitivity in their internal organs, suggesting a dual functionality of light detection and emission in these photophores.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Qi Chen, Naval Singh, Kerstin Schirrmann, Qi Zhou, Igor L. Chernyavsky, Anne Juel
Summary: In this paper, we design a suspension of microcapsules that can flow and deform like red blood cells, serving as a valuable tool for investigating microhemodynamics. These microcapsules with hyperelastic membranes are obtained by cross-linking a polydimethylsiloxane layer coating water-oil-water double emulsions. We compare the deformation of initially spherical and deflated capsules in cylindrical capillaries and find that only deflated capsules deform broadly like RBCs within a certain range of capillary numbers.
Review
Chemistry, Multidisciplinary
Dafei Sheng, Xinlin Li, Chao Sun, Junwen Zhou, Xiao Feng
Summary: Separation membranes are essential in the functioning of artificial organs. The COVID-19 pandemic has underscored their importance in the medical community. However, there are challenges in membrane technology, such as clearing toxins and improving blood compatibility. This review discusses the mechanisms, performance, and biocompatibility of separation membranes in artificial organs, as well as the opportunities and challenges for next-generation membrane technology.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Instruments & Instrumentation
Yaofeng Wang, Fan Wang, Yang Kong, Lei Wang, Qinchuan Li
Summary: This research presents a high-performance ionic bioartificial muscle based on a nanocomposite membrane of bacterial cellulose/ionic liquid/multi-walled carbon nanotubes and PEDOT:PSS electrode. The developed muscle exhibits low-cost, large bending deformation, low actuation voltage, and fast response time. It shows excellent properties in electro-chemo-mechanical performance and ionically crosslinked structure, making it a promising candidate for next-generation artificial muscles, soft robotics, and other related fields.
SMART MATERIALS AND STRUCTURES
(2022)
Review
Biotechnology & Applied Microbiology
Parth Chansoria, Emma L. Etter, Juliane Nguyen
Summary: Regenerating dynamic organs is challenging due to anisotropic nature and volumetric deformation, but new patches with anisotropic and auxetic properties mimic native tissue biomechanics. Critical considerations in design, materials, and processing for optimal patch biomechanics are key, with recent advances showing promise for dynamic organ regeneration. Overcoming challenges and seizing opportunities could lead to new applications in organ regeneration and speed up clinical translation of patch-based therapeutics.
TRENDS IN BIOTECHNOLOGY
(2022)
