4.7 Article

Modeling the complex dynamics and changing correlations of epileptic events

Journal

ARTIFICIAL INTELLIGENCE
Volume 216, Issue -, Pages 55-75

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.artint.2014.05.006

Keywords

Bayesian nonparametric; EEG; Factorial hidden Markov model; Graphical model; Time series

Funding

  1. AFOSR [FA9550-12-1-0453]
  2. DARPA [FA9550-12-1-0406]
  3. ONR [N00014-10-1-0746]
  4. NINDS [RO1-NS041811, RO1-NS48598, U24-NS063930-03]
  5. Mirowski Discovery Fund for Epilepsy Research

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Patients with epilepsy can manifest short, sub-clinical epileptic bursts in addition to full-blown clinical seizures. We believe the relationship between these two classes of events something not previously studied quantitatively-could yield important insights into the nature and intrinsic dynamics of seizures. A goal of our work is to parse these complex epileptic events into distinct dynamic regimes. A challenge posed by the intracranial EEG (iEEG) data we study is the fact that the number and placement of electrodes can vary between patients. We develop a Bayesian nonparametric Markov switching process that allows for (i) shared dynamic regimes between a variable number of channels, (ii) asynchronous regime-switching, and (iii) an unknown dictionary of dynamic regimes. We encode a sparse and changing set of dependencies between the channels using a Markov-switching Gaussian graphical model for the innovations process driving the channel dynamics and demonstrate the importance of this model in parsing and out-of-sample predictions of iEEG data. We show that our model produces intuitive state assignments that can help automate clinical analysis of seizures and enable the comparison of sub-clinical bursts and full clinical seizures. (C) 2014 Elsevier B.V. All rights reserved.

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