Journal
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
Volume 39, Issue 3, Pages 162-168Publisher
INFORMA HEALTHCARE
DOI: 10.3109/10731199.2010.516261
Keywords
alpha-hydroxy ketone; benzoin; deracemization; ultrasound; hydrolysis; Rhizopus oryzae
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Funding
- Scientific and Technical Research Council of Turkey, TUBITAK [104M148]
- Ankara University [20060745050]
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In this study, the production of enantiopure benzoin from rac-benzoin acetate was achieved by lipase catalyzed kinetic resolution combined with deracemization using Rhizopus oryzae (CBS111718). The growth cells were pretreated with 20 kHz and 30 kHz ultrasound irradiation and mechanical homogenization. Approximately 100% conversion and 96% enantiomeric excess of the product (S-benzoin) were obtained by applying 20 kHz ultrasound irradiation at pH 6. The deracemization process involves new and important processes that allow for the transformation of a racemate into a single stereoisomeric product in 100% theoretical yields. Moreover, the application of ultrasound increases the conversion rate by reducing mass transfer limitation.
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