Article
Rheumatology
Anu Balakrishnan, Sanjukta Majumder, Shivika Guleria, Able Lawrence, Amita Aggarwal
Summary: Macrophage migration inhibitory factor (MIF) and IgA antiCD74 antibodies play important roles in ankylosing spondylitis (AS) and enthesitis-related arthritis (ERA). The study found that serum MIF levels were higher in ERA patients and correlated with disease activity; synovial fluid MIF levels were even higher, indicating a potential role in synovitis seen in ERA. IgA antiCD74 antibodies were rarely detected in ERA patients.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Oncology
Benjamin L. Woolbright, Ganeshkumar Rajendran, Erika Abbott, Austin Martin, Sarah Amalraj, Katie Dennis, Xiaogang Li, Joshua Warrick, John A. Taylor
Summary: MIF2 functions similarly to MIF1 in promoting bladder cancer development and progression, partly through CD74. Dual inhibition of MIF homologs is more effective in reducing tumor burden in bladder cancer compared to single inhibition of MIF1.
JOURNAL OF PATHOLOGY
(2023)
Article
Cell Biology
Keren David, Gilgi Friedlander, Bianca Pellegrino, Lihi Radomir, Hadas Lewinsky, Lin Leng, Richard Bucala, Idit Shachar, Shirly Becker Herman
Summary: This study investigated the transcriptional and regulatory function of CD74-ICD in normal B cells. It was found that CD74-ICD forms a complex with PAX5 and binds to chromatin at a higher number of sites compared to CLL cells. The CD74-ICD:PAX5 complex also downregulates the expression of the tumor-suppressor gene DMTF1 through transcriptional inhibition.
Article
Pharmacology & Pharmacy
Theresa H. Wirtz, Alena Saal, Irina Bergmann, Petra Fischer, Daniel Heinrichs, Elisa F. Brandt, Maria T. Koenen, Sonja Djudjaj, Kai M. Schneider, Peter Boor, Richard Bucala, Ralf Weiskirchen, Jurgen Bernhagen, Christian Trautwein, Marie-Luise Berres
Summary: The study identified a pro-tumorigenic role of MIF in the proliferation and therapy-induced apoptosis of HCC cells, mediated through the MIF cognate receptor CD74.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Pasathorn Yodtaweepornanan, Wanjak Pongsittisak, Panchalee Satpanich
Summary: This study analyzed adults diagnosed with chikungunya infection between 2015 and 2020 at a medical center. It found that 40.4% of the patients developed chronic chikungunya arthritis. The initial number of joints with arthritis, initial VAS scores, and female sex were predictive factors for chronic chikungunya arthritis.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2023)
Article
Virology
Alperen Aksakal, Bugra Kerget, Ferhan Kerget, Seda Askin
Summary: The study revealed the correlation between serum migration inhibitory factor (MIF) level and disease severity in COVID-19, with higher MIF levels potentially indicating a more severe condition. MIF levels can serve as an important predictive indicator for early disease prognosis in COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emily Chen, Krystle Reiss, Dilip Shah, Ramu Manjula, Brandon Allen, Eva L. Murphy, James W. Murphy, Victor S. Batista, Vineet Bhandari, Elias J. Lolis, George P. Lisi
Summary: Despite the low sequence identity, the study revealed a conserved dynamic regulatory network between MIF and MIF-2, with the structural basis of an allosteric site in MIF-2 being established. Molecular simulations showed a comparable hydrogen bond network in MIF-2, suggesting its influence on catalytic activity through modulating allosteric coupling. Disruption of the allosteric relay in MIF-2 attenuated enzymatic activity in vitro and receptor activation in vivo, indicating a conserved point of control for nonoverlapping functions in the MIF superfamily.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Juan Cai, Lin Huang, Hongri Tang, Hongling Xu, Lingjun Wang, Minghui Zheng, Hongsong Yu, Hui Liu
Summary: The MIF produced by Thelazia callipaeda can induce M2-like macrophage polarization through TLR4-mediated activation of the PI3K-Akt pathway, potentially aiding in disrupting the host immune system.
Article
Biochemistry & Molecular Biology
Xuxu Wang, Tao Sun, Xiaohua Mao
Summary: MascRNA has been found to play a crucial role in the treatment of rheumatoid arthritis by promoting apoptosis and suppressing the expression of osteoclast marker genes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Integrative & Complementary Medicine
Zhou Haiyan, Zhong Yumei, Gao Xiuhua, Wu Fei, Jia Min, Yang Xin
Summary: Moxibustion can regulate the expression of MIF and its related signaling pathways molecules, promote apoptosis of macrophages in synovial tissue, as well as reduce the level of inflammatory factors in synovial fluid, suggesting its potential anti-inflammatory effect on RA.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mauro Vasella, Stefan Wolf, Eamon C. Francis, Gerrit Grieb, Pablo Pfister, Gregory Reid, Juergen Bernhagen, Nicole Lindenblatt, Epameinondas Gousopoulos, Bong-Sung Kim
Summary: Lipedema is a chronic disorder mainly affecting women, with an unknown etiology. Recent research suggests that the accumulation and polarization of macrophages may be involved in lipedema. This study provides evidence for the potential involvement of the MIF family, specifically the MIF-1-CD74 axis, in lipedema.
Article
Medicine, Research & Experimental
Lei Cao, Xiuqing Wang, Xiaoyi Liu, Wei Meng, Wenli Guo, Chenyang Duan, Xiaoyan Liang, Lifei Kang, Ping Lv, Qiang Lin, Rong Zhang, Xianghong Zhang, Haitao Shen
Summary: This study explores the role of MIF-CD74 in the progression of lung adenocarcinoma and its underlying mechanisms. The interaction between MIF and CD74 promotes the proliferation and migration of lung adenocarcinoma cells. TNF-a-mediated lung inflammation contributes to the progression of lung adenocarcinoma by upregulating CD74 and MIF expression.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Ji Ae Kim, Ye Young Kim, Seung Hak Lee, Chul Jung, Mi Hee Kim, Dae Yul Kim
Summary: The macrophage migration inhibitory factor (MIF) exerts a neuroprotective effect, facilitating neurological recovery and protecting brain tissue from ischemic injury in an in vivo model of ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Zhengshi Zhang, Xiucong Hu, Qianying Diao, Panpan Zhang, Ying Wu, Zhenjie Cao, Yongcan Zhou, Chunsheng Liu, Yun Sun
Summary: In this study, a macrophage migration inhibitory factor (TroMIF) was identified from golden pompano and its function was analyzed. TroMIF showed high similarity with other known MIF sequences and was most closely related to large yellow croaker. TroMIF was highly expressed in the liver and head kidney and its expression was up-regulated after E. tarda infection. In vitro experiments showed that rTroMIF could inhibit the migration of lymphocytes and macrophages and enhance macrophage phagocytic activity. Furthermore, rTroMIF increased the expression levels of pro-inflammatory cytokines and had enzymatic redox activity. Overexpression of TroMIF enhanced the ability to resist E. tarda infection, while knockdown of TroMIF expression increased the bacterial load. These results suggest that TroMIF plays an important role in antibacterial immunity.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ella Peled, Alejandro Sosnik
Summary: The study shows that drug-free nanoparticles are capable of inducing polarization of macrophages to an M2-like phenotype and accelerating wound healing. Additionally, in vitro experiments demonstrate that M2 polarization increases fibroblast migration significantly.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Rheumatology
Yoshiya Tanaka, Tatsuya Atsumi, Masato Okada, Tomoya Miyamura, Tomonori Ishii, Susumu Nishiyama, Ryutaro Matsumura, Nobuya Hayashi, Gabriel Abreu, Raj Tummala, Eric F. Morand, Tsutomu Takeuchi
Summary: This study evaluated the efficacy and safety of anifrolumab in Japanese patients with SLE. The results showed that anifrolumab was more effective than placebo in improving patients' condition and reducing skin activity. In terms of safety, anifrolumab had a profile consistent with the overall population.
MODERN RHEUMATOLOGY
(2023)
Article
Rheumatology
Sayuri Yamashita, Yasuhiro Katsumata, Naoko Konda, Rangi Kandane-Rathnayake, Eric F. Morand, Masayoshi Harigai
Summary: This study compared the US norm-based two-component and Japanese norm-based three-component models of the Medical Outcomes Study Short Form-36 (SF-36) in patients with systemic lupus erythematosus (SLE). The results showed that although the agreement between the two models was insufficient, their scores demonstrated similar associations with other variables.
MODERN RHEUMATOLOGY
(2023)
Article
Cell Biology
Sarah L. Snelgrove, Olivia Susanto, Louisa Yeung, Pamela Hall, M. Ursula Norman, Alexandra J. Corbett, A. Richard Kitching, Michael J. Hickey
Summary: This study developed a flow cytometry strategy to characterize the phenotype and response of DN T cells in the kidney. The experiments revealed that DN T cells are primarily located within the renal parenchyma and have an effector memory phenotype. Following renal ischemia-reperfusion injury, the number of DN T cells significantly increases after 72 hours, partly due to recruitment from the circulation. The observation that DN T cells can upregulate CD8 in vivo has important implications for future studies.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Article
Infectious Diseases
Elina Panahi, Danielle I. Stanisic, Eloise B. Skinner, Helen M. Faddy, Megan K. Young, Lara J. Herrero
Summary: This study examined whether humans have an immunoglobulin G (IgG) response to the Leishmania (Mundinia) macropodum parasite, which causes cutaneous leishmaniasis among marsupial species in Australia. The results showed that 20.57% of individuals demonstrated a positive IgG response to L. macropodum. However, it is unclear whether this IgG antibody detection reflects exposure to Leishmania parasites or a cross-reactive immune response to an unrelated immunogen.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Elisa X. Y. Lim, Julie A. A. Webster, Penny A. A. Rudd, Lara J. J. Herrero
Summary: This study used RNA sequencing to analyze the gene expression profiles of Ross River virus (RRV)-infected chondrocytes and bystander chondrocytes. The results showed similarities and differences in gene expression between infected and uninfected cells, indicating the importance of selecting therapeutic targets that minimize adverse effects on neighboring uninfected cells.
Article
Rheumatology
Eric Morand, Marilyn Pike, Joan T. Merrill, Ronald van Vollenhoven, Victoria P. Werth, Coburn Hobar, Nikolay Delev, Vaishali Shah, Brian Sharkey, Thomas Wegman, Ian Catlett, Subhashis Banerjee, Shalabh Singhal
Summary: Deucravacitinib treatment showed higher response rates for SRI-4 and other endpoints compared to placebo, with an acceptable safety profile, in adult patients with active SLE.
ARTHRITIS & RHEUMATOLOGY
(2023)
Editorial Material
Urology & Nephrology
Michael J. J. Hickey
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Letter
Virology
Peter Speck, Jason Mackenzie, Rowena A. Bull, Barry Slobedman, Heidi Drummer, Johanna Fraser, Lara Herrero, Karla Helbig, Sarah Londrigan, Gregory Moseley, Natalie Prow, Grant Hansman, Robert Edwards, Chantelle Ahlenstiel, Allison Abendroth, David Tscharke, Jody Hobson-Peters, Robson Kriiger-Loterio, Rhys Parry, Glenn Marsh, Emma Harding, David A. Jacques, Matthew J. Gartner, Wen Shi Lee, Julie McAuley, Paola Vaz, Frank Sainsbury, Michelle D. Tate, Jane Sinclair, Allison Imrie, Stephen Rawlinson, Andrew Harman, Jillian M. Carr, Ebony A. Monson, Merilyn Hibma, Timothy J. Mahony, Thomas Tu, Robert J. Center, Lok Bahadur Shrestha, Robyn Hall, Morgyn Warner, Vernon Ward, Danielle E. Anderson, Nicholas S. Eyre, Natalie E. Netzler, Alison J. Peel, Peter Revill, Michael Beard, Alistair R. Legione, Alexandra J. Spencer, Adi Idris, Jade Forwood, Subir Sarker, Damian F. J. Purcell, Nathan Bartlett, Joshua M. Deerain, Bruce J. Brew, Sassan Asgari, Helen Farrell, Alexander Khromykh, Daniel Enosi Tuipulotu, David Anderson, Sevim Mese, Yaman Tayyar, Kathryn Edenborough, Jasim Muhammad Uddin, Abrar Hussain, Connor J. I. Daymond, Jacinta Agius, Karyn N. Johnson, Paniz Shirmast, Mahdi Abedinzadeshahri, Robin MacDiarmid, Caroline L. Ashley, Jay Laws, Lucy L. Furfaro, Thomas D. Burton, Stephen M. R. Johnson, Zahra Telikani, Mary Petrone, Justin A. Roby, Carolyn Samer, Andreas Suhrbier, April van der Kamp, Anthony Cunningham, Celeste Donato, Jackie Mahar, Wesley D. Black, Subhash Vasudevan, Roman Lenchine, Kirsten Spann, Daniel J. Rawle, Penny Rudd, Jessica Neil, Richard Kingston, Timothy P. Newsome, Ki Wook Kim, Johnson Mak, Kym Lowry, Nathan Bryant, Joanne Meers, Jason A. Roberts, Nigel McMillan, Larisa I. Labzin, Andrii Slonchak, Leon E. Hugo, Bennett Henzeler, Natalee D. Newton, Cassandra T. David, Patrick C. Reading, Camille Esneau, Tatiana Briody, Najla Nasr, Donna McNeale, Brian McSharry, Omid Fakhri, Bethany A. Horsburgh, Grant Logan, Paul Howley, Paul Young
JOURNAL OF VIROLOGY
(2023)
Letter
Microbiology
Peter Speck, Jason Mackenzie, Rowena A. Bull, Barry Slobedman, Heidi Drummer, Johanna Fraser, Lara Herrero, Karla Helbig, Sarah Londrigan, Gregory Moseley, Natalie Prow, Grant Hansman, Robert Edwards, Chantelle Ahlenstiel, Allison Abendroth, David Tscharke, Jody Hobson-Peters, Robson Kriiger-Loterio, Rhys Parry, Glenn Marsh, Emma Harding, David A. Jacques, Matthew J. Gartner, Wen Shi Lee, Julie McAuley, Paola Vaz, Frank Sainsbury, Michelle D. Tate, Jane Sinclair, Allison Imrie, Stephen Rawlinson, Andrew Harman, Jillian M. Carr, Ebony A. Monson, Merilyn Hibma, Timothy J. Mahony, Thomas Tu, Robert J. Center, Lok Bahadur Shrestha, Robyn Hall, Morgyn Warner, Vernon Ward, Danielle E. Anderson, Nicholas S. Eyre, Natalie E. Netzler, Alison J. Peel, Peter Revill, Michael Beard, Alistair R. Legione, Alexandra J. Spencer, Adi Idris, Jade Forwood, Subir Sarker, Damian F. J. Purcell, Nathan Bartlett, Joshua M. Deerain, Bruce J. Brew, Sassan Asgari, Helen Farrell, Alexander Khromykh, Daniel Enosi Tuipulotu, David Anderson, Sevim Mese, Yaman Tayyar, Kathryn Edenborough, Jasim Muhammad Uddin, Abrar Hussain, Connor J. Daymond, Jacinta Agius, Karyn N. Johnson, Paniz Shirmast, Mahdi Abedinzadeshahri, Robin MacDiarmid, Caroline L. Ashley, Jay Laws, Lucy L. Furfaro, Thomas D. Burton, Stephen M. R. Johnson, Zahra Telikani, Mary Petrone, Justin A. Roby, Carolyn Samer, Andreas Suhrbier, April van der Kamp, Anthony Cunningham, Celeste Donato, Jackie Mahar, Wesley D. Black, Subhash Vasudevan, Roman Lenchine, Kirsten Spann, Daniel J. Rawle, Penny Rudd, Jessica Neil, Richard Kingston, Timothy P. Newsome, Ki Wook Kim, Johnson Mak, Kym Lowry, Nathan Bryant, Joanne Meers, Jason A. Roberts, Nigel McMillan, Larisa I. Labzin, Andrii Slonchak, Leon E. Hugo, Bennett Henzeler, Natalee D. Newton, Cassandra T. David, Patrick C. Reading, Camille Esneau, Tatiana Briody, Najla Nasr, Donna McNeale, Brian McSharry, Omid Fakhri, Bethany A. Horsburgh, Grant Logan, Paul Howley, Paul Young
Correction
Medicine, General & Internal
Koen Bartholomeeusen, Matthieu Daniel, Desiree A. A. LaBeaud, Philippe Gasque, Rosanna W. W. Peeling, Kathryn E. E. Stephenson, Lisa F. P. Ng, Kevin K. K. Arien
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Medicine, General & Internal
Koen Bartholomeeusen, Matthieu Daniel, Desiree A. LaBeaud, Philippe Gasque, Rosanna W. Peeling, Kathryn E. Stephenson, Lisa F. P. Ng, Kevin K. Arien
Summary: Chikungunya virus is a widespread and recurring infectious disease that causes severe joint and muscle pain. It is transmitted by Aedes mosquitoes and has been causing outbreaks in various regions due to climate change and globalization. With no specific treatment or vaccines available, surveillance and vector control measures are crucial in preventing further re-emergence and epidemics.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Letter
Microbiology
Peter Speck, Jason Mackenzie, Rowena A. Bull, Barry Slobedman, Heidi Drummer, Johanna Fraser, Lara Herrero, Karla Helbig, Sarah Londrigan, Gregory Moseley, Natalie Prow, Grant Hansman, Robert Edwards, Chantelle Ahlenstiel, Allison Abendroth, David Tscharke, Jody Hobson-Peters, Robson Kriiger-Loterio, Rhys Parry, Glenn Marsh, Emma Harding, David A. Jacques, Matthew J. Gartner, Wen Shi Lee, Julie McAuley, Paola Vaz, Frank Sainsbury, Michelle D. Tate, Jane Sinclair, Allison Imrie, Stephen Rawlinson, Andrew Harman, Jillian M. Carr, Ebony A. Monson, Merilyn Hibma, Timothy J. Mahony, Thomas Tu, Robert J. Center, Lok Bahadur Shrestha, Robyn Hall, Morgy Warner, Vernon Ward, Danielle E. Anderson, Nicholas S. Eyre, Natalie E. Netzler, Alison J. Peel, Peter Revill, Michael Beard, Alistair R. Legione, Alexandra J. Spencer, Adi Idris, Jade Forwood, Subir Sarker, Damian F. J. Purcell, Nathan Bartlett, Joshua M. Deerain, Bruce J. Brew, Sassan Asgari, Helen Farrell, Alexander Khromykh, Daniel Enosi Tuipulotu, David Anderson, Sevim Mese, Yaman Tayyar, Kathryn Edenborough, Jasim Muhammad Uddin, Abrar Hussain, Connor J. I. Daymond, Jacinta Agius, Karyn N. Johnson, Paniz Shirmast, Mahdi Abedinzadeshahri, Robin MacDiarmid, Caroline L. Ashley, Jay Laws, Lucy L. Furfaro, Thomas D. Burton, Stephen M. R. Johnson, Zahra Telikani, Mary Petrone, Justin A. Roby, Carolyn Samer, Andreas Suhrbier, April van der Kamp, Anthony Cunningham, Celeste Donato, Jackie Mahar, Wesley D. Black, Subhash Vasudevan, Roman Lenchine, Kirsten Spann, Daniel J. Rawle, Penny Rudd, Jessica Neil, Richard Kingston, Timothy P. Newsome, Ki Wook Kim, Johnson Mak, Kym Lowry, Nathan Bryant, Joanne Meers, Jason A. Roberts, Nigel McMillan, Larisa I. Labzin, Andrii Slonchak, Leon E. Hugo, Bennett Henzeler, Natalee D. Newton, Cassandra T. David, Patrick C. Reading, Camille Esneau, Tatiana Briody, Najla Nasr, Donna McNeale, Brian McSharry, Omid Fakhri, Bethany A. Horsburgh, Grant Logan, Paul Howley, Paul Young
Article
Hematology
ZheHao Tan, Pam Hall, Adam Costin, Simon A. Crawford, Georg Ramm, Connie H. Y. Wong, A. Richard Kitching, Michael J. Hickey
Summary: The role of the endothelial surface layer (ESL) in recruiting monocytes and neutrophils in glomerular capillaries is unclear. This study shows that the ESL does not modulate the trafficking and retention of these immune cells in both steady-state and acutely-inflamed glomeruli.
Article
Rheumatology
Eric Morand, Josef S. Smolen, Michelle Petri, Yoshiya Tanaka, Maria Silk, Christina Dickson, Gabriella Meszaros, Inmaculada de la Torre, Maher Issa, Hong Zhang, Thomas Doerner
Summary: This study aimed to assess the safety of the oral Janus kinase inhibitor baricitinib in adult patients with systemic lupus erythematosus (SLE) receiving stable background therapy. The results showed that the infection rate was slightly higher in the baricitinib treatment group compared to the placebo group, but there were no significant adverse events. The incidence of venous thromboembolism was low.
Article
Rheumatology
Matthew Studham, Cristina Vazquez-Mateo, Eileen Samy, Philipp Haselmayer, Aida Aydemir, P. Alexander Rolfe, Joan T. Merrill, Eric F. Morand, Julie Demartino, Amy Kao, Robert Townsend
Summary: This study aims to identify SLE patients most likely to respond to atacicept in the APRIL-SLE and ADDRESS II trials using cell-based gene signatures. An immune cell deconvolution algorithm was applied to analyze gene expression data and five distinct patient clusters were identified. The study also developed a modified immune cell deconvolution algorithm based on RNA sequencing data to identify similar patient clusters and their responses in the ADDRESS II trial.
ACR OPEN RHEUMATOLOGY
(2023)