Article
Immunology
Qinghua Fang, Tingyue Li, Peiya Chen, Yuzhe Wu, Tingting Wang, Lixia Mo, Jiaxin Ou, Kutty Selva Nandakumar
Summary: Comprehensive bioinformatics analysis identified abnormally methylated DEGs and potential biomarker genes in different immune cells of RA and SLE, suggesting differences in disease pathways. Integration of multiple data sets can achieve more dependable and precise results filtering.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Yujue He, Junyu Lin, Jifeng Tang, Ziqing Yu, Qishui Ou, Jinpiao Lin
Summary: Differential protein expression in the sera of seropositive rheumatoid arthritis (SPRA) and seronegative rheumatoid arthritis (SNRA) patients was identified in this study, with 14 proteins showing significant differences. ELISA validation confirmed elevated levels of SAA1 in SPRA and SNRA patients, and increased levels of PSME1 in SPRA patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Multidisciplinary Sciences
Helen R. Gosselt, Costanza L. Vallerga, Pooja R. Mandaviya, Erik Lubberts, Johanna M. W. Hazes, Robert de Jonge, Sandra G. Heil
Summary: The study did not identify genome-wide significant differences as biomarkers for Methotrexate (MTX) therapy response, necessitating meta-analyses.
Article
Medicine, Research & Experimental
Runrun Zhang, Cen Chang, Yehua Jin, Lingxia Xu, Ping Jiang, Kai Wei, Linshuai Xu, Shicheng Guo, Songtao Sun, Dongyi He
Summary: This study identified novel DNA methylation-regulated differentially expressed genes (MeDEGs) in rheumatoid arthritis (RA) through integrated analysis of DNA methylation and RNA-Seq data. The results suggest that RGS1 could serve as a potential methylated biomarker for RA.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Li Xue, Biao Wang, Jianhong Zhu, Qian He, Fang Huang, Wei Wang, Li Tao, Yan Wang, Nan Xu, Ni Yang, Li Jin, Hua Zhang, Ning Gao, Ke Lei, Yanping Zhang, Chaoliang Xiong, Jing Lei, Ting Zhang, Yan Geng, Ming Li
Summary: This study aimed to investigate the key circRNAs related to rheumatoid arthritis (RA) by identifying differentially expressed circRNAs (DEcircRNAs) in peripheral blood mononuclear cells (PBMCs) from RA patients compared to controls and osteoarthritis (OA) patients. Real-time PCR validation and correlation analysis with laboratory indices were also performed. The functional annotation of host genes of the DEcircRNAs in RA revealed their involvement in metabolic pathways, ECM-receptor interaction, and the PI3K-Akt signalling pathway. These findings contribute to a better understanding of the role of circRNAs in the specific mechanism underlying RA.
ANNALS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Gabriela Athziri Sanchez-Zuno, Richard Bucala, Jorge Hernandez-Bello, Ilce Valeria Roman-Fernandez, Mariel Garcia-Chagollan, Ferdinando Nicoletti, Monica Guadalupe Matuz-Flores, Samuel Garcia-Arellano, Judith Alejandra Esparza-Michel, Sergio Cerpa-Cruz, Edsaul Emilio Perez-Guerrero, Jose Francisco Munoz-Valle
Summary: Macrophage migration inhibitory factor (MIF) plays a significant role in the pathogenesis of rheumatoid arthritis (RA). This study explored the expression of CD74, CXCR2, CXCR4, and CXCR7, as well as the levels of soluble CD74 (sCD74), in relation to the clinical activity of RA. The results suggest that sCD74 may act as a decoy receptor for MIF and negatively regulate its signaling, while CXCR7 functions as a scavenger-type receptor to prevent endocytosis and degradation of CXCR4 under inflammatory conditions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Chunling Li, Tianshu Chu, Zhiyi Zhang, Yue Zhang
Summary: The study aimed to investigate the regulation of Treg cells in early rheumatoid arthritis pathogenesis through arsenic trioxide (As2O3) and found that As2O3 had significant effects on gene expression in early treatment-naive RA Treg cells. As2O3 modulated CD4(+) T cells towards Treg cells and affected genes associated with inflammation, Treg-cell activation, differentiation, and cellular metabolism. The KEGG pathway analysis identified several pathways involved in the pathogenesis of early treatment-naive RA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
M. Vomero, M. Caliste, C. Barbati, M. Speziali, A. I. Celia, F. Ucci, C. Ciancarella, E. Putro, T. Colasanti, G. Buoncuore, E. Corsiero, M. Bombardieri, F. R. Spinelli, F. Ceccarelli, F. Conti, C. Alessandri
Summary: The study demonstrates that tofacitinib has the ability to modulate autophagy in fibroblast-like synoviocytes, contributing to its effectiveness in treating patients with rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Yan Liu, Michael J. Caterina, Lintao Qu
Summary: Persistent arthritis pain after resolution of joint inflammation is a significant problem in patients with rheumatoid arthritis (RA). This study suggests that sensory neuron expressed Fc gamma RI may play a role in postinflammatory arthritis pain. Deletion of Fcgr1 can alleviate mechanical hyperalgesia in a mouse model of collagen antibody-induced arthritis. Neuroinflammation within the dorsal root ganglion (DRG) may upregulate Fc gamma RI signaling in DRG neurons. Sensory neuron expressed Fc gamma RI is a potential target for the treatment of arthritis pain that persists in RA patients in remission.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Rajesh Detroja, Sumit Mukherjee, Milana Frenkel-Morgenstern
Summary: This study demonstrates the presence of highly expressed and functional novel chimeric RNAs in rheumatoid arthritis (RA), which is significant for understanding the pathogenesis of RA and providing better treatment strategies and tailored therapies.
Article
Biochemistry & Molecular Biology
Minseon Kim, Yongae Kim
Summary: Cytokine imbalance leads to inflammation, which is difficult to treat without side effects. Therefore, we aimed to develop a peptide drug with minimal side effects. Previous research identified three peptides with anti-inflammatory activity based on a truncated IK (tIK) protein. This study optimized the process of expressing, isolating, and purifying the peptides using bacterial strains and analyzed their secondary structure using circular dichroism and nuclear magnetic resonance spectroscopy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Sarah M. McAlpine, Sarah E. Roberts, Breanna K. V. Hargreaves, Claire Bullock, Suzanne Ramsey, Elizabeth Stringer, Bianca Lang, Adam Huber, Bence Gyorgy, Fruzsina Erdelyi, Thomas B. Issekutz, Beata Derfalvi
Summary: This study evaluated the expression of microRNAs in synovial fluid, plasma, and leukocytes from patients with juvenile idiopathic arthritis (JIA). The results showed dysregulated expression of multiple microRNAs in JIA, both locally and systemically. These findings provide important insights into the pathogenesis of JIA and may have implications for targeted therapies.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Vijay Kanoje, Dilip Pandey, Akshaya Wagh, Sukanya Patra, Ajit Kumar Marisetti, Madhusudhan Reddy, Charudatt Samant, Nilesh Mahajan, Milind Gholve, Sudeep Sabde, Sneha Trivedi, Trupti Bhankhede, Vinod Patil, Prashant Nigade, Dipak Modi, Maneesh Mehta, Prajakta Ahirrao, Swathi Tota, Bidyut Nanda, Shashikant Pawar, Anuradha Polawar, Kaustubh Tamane, Sandip Kuldharan, Gururaj Vishwase, Nirmal Jana, Sachin J. Mahangare, Prashant Vidhate, Dipak Lagad, Jayasagar Gundu, Samiron Phukan, Manojkumar Shukla, Lakshmi Narasimham, Kumar V. S. Nemmani, Mandar Bhonde, Sharad Sharma, Rajender K. Kamboj, Venkata P. Palle
Summary: This study describes the in vitro and in vivo activity and drug-like properties of the PI3K delta specific inhibitor LL-00071210 in rheumatoid arthritis models. LL-00071210 shows excellent selectivity and stability, demonstrating potential as a clinical drug for the treatment of autoimmune diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Parasitology
Zhongqiu Li, Yuan Fang, Yi Zhang, Xiaonong Zhou
Summary: This study aimed to explore the differentially expressed LncRNAs in leishmaniasis. High-throughput sequencing was used to analyze the sera of leishmaniasis patients and uninfected persons. Results showed 970 differentially expressed LncRNAs and 1692 differentially expressed mRNAs. Bioinformatics analysis revealed that these differentially expressed genes were enriched in specific pathways related to autophagy, signaling pathways, and apoptosis. This study provides novel insights into the potential function of LncRNAs in leishmaniasis and their role in diagnosis of this parasitic disease.
Article
Cell Biology
Clara Cambria, Francesca Ingegnoli, Eleonora Borzi, Laura Cantone, Lavinia Agra Coletto, Alessandra Stefania Rizzuto, Orazio De Lucia, Sabrina Briguglio, Massimiliano Ruscica, Roberto Caporali, Valentina Bollati, Massimiliano Buoli, Flavia Antonucci
Summary: Arthritides is a group of diverse disorders that affect joints, including localized joint disorders and systemic autoimmune-driven diseases. Poor mental health is common among arthritides patients. Research has shown that extracellular vesicles derived from synovial fluid can affect neuronal function, and the concentration of synovial vesicles is associated with psychiatric symptoms in arthritides patients.
Review
Rheumatology
Ahmed S. Hassan, Allison Rao, Augustine M. Manadan, Joel A. Block
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2017)
Article
Rheumatology
Nisarg P. Gandhi, Augustine M. Manadan, Joel A. Block
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2017)
Article
Rheumatology
D. R. Azizoddin, S. Weinberg, N. Gandhi, S. Arora, J. A. Block, W. Sequeira, M. Jolly
Article
Rheumatology
A. Kugasia, N. Sehgal, M. Dollear, W. Sequeira, J. A. Block, M. Jolly
Article
Rheumatology
Nisarg Gandhi, Shilpa Arora, Mondira Sengupta, Winston Sequeira, Meenakshi Jolly, Joel A. Block
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2018)
Article
Rheumatology
N. Annapureddy, D. Giangreco, H. Devilliers, J. A. Block, M. Jolly
Review
Rheumatology
Rachel E. Miller, Joel A. Block, Anne-Marie Malfait
Article
Rheumatology
Shilpa Arora, Ailda Nika, Laura Trupin, Hrudya Abraham, Joel Block, Winston Sequeira, Jinoos Yazdany, Meenakshi Jolly
ARTHRITIS CARE & RESEARCH
(2018)
Article
Rheumatology
Teresa A. Lillis, Vanessa Tirone, Nisarg Gandhi, Stacy Weinberg, Ailda Nika, Winston Sequeira, Stevan E. Hobfoll, Joel A. Block, Meenakshi Jolly
ARTHRITIS CARE & RESEARCH
(2019)
Article
Rheumatology
Meenakshi Jolly, Winston Sequeira, Joel A. Block, Sergio Toloza, Ana Bertoli, Ivanna Blazevic, Luis M. Vila, Ioana Moldovan, Karina D. Torralba, Davide Mazzoni, Elvira Cicognani, Sarfaraz Hasni, Berna Goker, Seminur Haznedaroglu, Josiane Bourre-Tessier, Sandra V. Navarra, Chi Chiu Mok, Michael Weisman, Ann E. Clarke, Daniel Wallace, Graciela Alarcon
ARTHRITIS CARE & RESEARCH
(2019)
Article
Orthopedics
Anisha B. Dua, Tuhina Neogi, Rachel A. Mikolaitis, Joel A. Block, Najia Shakoor
BMC MUSCULOSKELETAL DISORDERS
(2018)
Article
Rheumatology
Isabel Castrejon, Najia Shakoor, Jacquelin R. Chua, Joel A. Block
RHEUMATOLOGY INTERNATIONAL
(2018)
Article
Rheumatology
Sobia Hassan, Meghan M. Smith, Joel A. Block, Meenakshi Jolly
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2019)
Article
Immunology
Seeyoung Choi, Teri Hatzihristidis, Guillaume Gaud, Avik Dutta, Jan Lee, Awadhesh Arya, Lauren M. Clubb, Daniel B. Stamos, Adrienn Markovics, Katalin Mikecz, Paul Love
Summary: THEMIS plays a critical role in T cell development by inhibiting SHP1 activity, and this is regulated by binding to GRB2.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Qingfeng Ding, Yongxin Ren, Hui Che, Cheng Ma, Huiwu Li, Suojing Yu, Yejia Zhang, Howard An, Regis J. O'Keefe, Di Chen, Joel A. Block, Guoyong Yin, Tianfang Li
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2018)