Are either or both hyperuricemia and xanthine oxidase directly toxic to the vasculature? A critical appraisal

Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007-2008

(2011) Yanyan Zhu et al.   ARTHRITIS AND RHEUMATISM

Urate as a Physiological Substrate for Myeloperoxidase

(2011) Flavia C. Meotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Insights Into the Therapeutic Use of High-Dose Allopurinol in Angina Pectoris

(2011) Narasimharajapura S. Rajendra et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Involvement of xanthine oxidase and hypoxia-inducible factor 1 in Toll-like receptor 7/8-mediated activation of caspase 1 and interleukin-1β

(2010) Sally A. Nicholas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Myeloperoxidase: An Oxidative Pathway for Generating Dysfunctional High-Density Lipoprotein

(2010) Baohai Shao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk

(2010) M. Goicoechea et al.   Clinical Journal of the American Society of Nephrology

Radicals in the reaction between peroxynitrite and uric acid identified by electron spin resonance spectroscopy and liquid chromatography mass spectrometry

(2010) Witcha Imaram et al.   FREE RADICAL BIOLOGY AND MEDICINE

Xanthine Oxidoreductase Promotes the Inflammatory State of Mononuclear Phagocytes through Effects on Chemokine Expression, Peroxisome Proliferator-activated Receptor-γ Sumoylation, and HIF-1α

(2010) Sophie Gibbings et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ImpairedS-Nitrosylation of the Ryanodine Receptor Caused by Xanthine Oxidase Activity Contributes to Calcium Leak in Heart Failure

(2010) Daniel R. Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uric acid promotes an acute inflammatory response to sterile cell death in mice

(2010) Hajime Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Differences in MSU-induced Superoxide Responses by Neutrophils from Gout Subjects Compared to Healthy Controls and a Role for Environmental Inflammatory Cytokines and Hyperuricemia in Neutrophil Function and Survival

(2010) W. J. MARTIN et al.   JOURNAL OF RHEUMATOLOGY

Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial

(2010) Awsan Noman et al.   LANCET

Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo

(2010) M. S. Hershfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial

(2010) Michael A Becker et al.   ARTHRITIS RESEARCH & THERAPY

Uric Acid and Hypertension: Cause or Effect?

(2010) Marilda Mazzali et al.   Current Rheumatology Reports

Effects of rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: A randomized placebo-controlled study

(2009) Ioannis Andreou et al.   ATHEROSCLEROSIS

Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1adenosine receptors

(2009) AP Schmidt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Allopurinol for pain relief: more than just crystal clearance?

(2009) Mark Connor   BRITISH JOURNAL OF PHARMACOLOGY

Uric Acid-Lowering Treatment With Benzbromarone in Patients With Heart Failure

(2009) Kazuhide Ogino et al.   Circulation-Heart Failure

Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin–angiotensin system

(2009) Dalila B Corry et al.   JOURNAL OF HYPERTENSION

Febuxostat in the treatment of gout: 5-yr findings of the FOCUS efficacy and safety study

(2009) H. R. Schumacher et al.   RHEUMATOLOGY

Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells

(2008) Sergey Zharikov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: A 28-week, phase III, randomized, double-blind, parallel-group trial

(2008) H. RALPH Schumacher et al.   ARTHRITIS AND RHEUMATISM

Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension

(2008) Daniel I. Feig et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography–mass spectrometry

(2008) Kyung Mee Kim et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Impact of Oxypurinol in Patients With Symptomatic Heart Failure

(2008) Joshua M. Hare et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Uric Acid and Cardiovascular Risk

(2008) Daniel I. Feig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antioxidant Status and Purine Bases in Carotid Artery Plaque

(2008) I. Ciari et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Uric Acid: The Oxidant-Antioxidant Paradox

(2008) Yuri Y. Sautin et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Inactivation of Nitric Oxide by Uric Acid

(2008) Christine Gersch et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS