A phase II, multicenter, open-label study evaluating dosing and preliminary safety and efficacy of canakinumab in systemic juvenile idiopathic arthritis with active systemic features

Networking in paediatrics: the example of the Paediatric Rheumatology International Trials Organisation (PRINTO)

(2011) Nicolino Ruperto et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Juvenile idiopathic arthritis

(2011) Berent Prakken et al.   LANCET

Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)

(2011) Jasmin B Kuemmerle-Deschner et al.   ARTHRITIS RESEARCH & THERAPY

A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial)

(2010) P. Quartier et al.   ANNALS OF THE RHEUMATIC DISEASES

Is it time to move to active comparator trials in juvenile idiopathic arthritis?: A review of current study designs

(2010) Nicolino Ruperto et al.   ARTHRITIS AND RHEUMATISM

Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: Report of forty-six patients from an international multicenter series

(2010) Peter A. Nigrovic et al.   ARTHRITIS AND RHEUMATISM

The emerging role of interleukin-1β in autoinflammatory diseases

(2010) Helen J. Lachmann et al.   ARTHRITIS AND RHEUMATISM

Methotrexate Withdrawal at 6 vs 12 Months in Juvenile Idiopathic Arthritis in RemissionA Randomized Clinical Trial

(2010) Dirk Foell   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

(2009) Helen J. Lachmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

The pattern of response to anti–interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis

(2008) Marco Gattorno et al.   ARTHRITIS AND RHEUMATISM

Persistent efficacy of anakinra in patients with tumor necrosis factor receptor–associated periodic syndrome

(2008) M. Gattorno et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial

(2008) Shumpei Yokota et al.   LANCET

Abatacept in children with juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled withdrawal trial

(2008) Nicolino Ruperto et al.   LANCET

Inflammasomes and rheumatic diseases: evolving concepts

(2007) P I Sidiropoulos et al.   ANNALS OF THE RHEUMATIC DISEASES