Article
Chemistry, Multidisciplinary
Hengli Lu, Jihu Wei, Kaiyuan Liu, Zihua Li, Tianyang Xu, Dong Yang, Qiuming Gao, Huijing Xiang, Guodong Li, Yu Chen
Summary: A dual-functional medication has been developed to protect cartilage and repair subchondral bone simultaneously. Black phosphorus nanosheets (BPNSs) effectively eliminate intracellular reactive oxygen species (ROS), restore chondrocyte function, and regulate inflammation, providing disease-modifying effects on osteoarthritis (OA). In vivo assessments confirm that BPNSs inhibit cartilage degradation and prevent OA progression, making them a competitive candidate for OA treatment.
Article
Engineering, Environmental
Godagama Gamaarachchige Dinesh Suminda, Yunhui Min, Min Woo Ha, Mrinmoy Ghosh, Dong-Sun Lee, Young-Ok Son
Summary: The study explores the role of arsenic (As) in the development of osteoarthritis (OA) in mice. Through chemical inhibition and inductively coupled plasma mass spectrometry analyses, the researchers identified the effects of As on chondrocytes and its accumulation in organs after oral administration. The findings show that As leads to heightened cartilage destruction and influences crucial cellular functions, activating specific pathways that disrupt articular cartilage homeostasis.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Review
Engineering, Biomedical
Shiyong Zhang, Liying Wang, Yunze Kang, Jun Wu, Ziji Zhang
Summary: Reactive oxygen species (ROS) have significant roles in physiological and pathophysiological processes. Recent studies have shown that ROS plays a crucial role in the development and progression of osteoarthritis (OA) by mediating extracellular matrix degradation, mitochondrial dysfunction, chondrocyte apoptosis, and OA progression. Nanomaterials with ROS-scavenging ability and antioxidant effects have shown promising results in OA treatment. However, current research on nanomaterials as ROS scavengers for OA is not uniform, and the timing and potential of their clinical use remain inconsistent. This review aims to provide a reference for further studies and promote the early clinical use of nanomaterials for OA treatment.
ACTA BIOMATERIALIA
(2023)
Article
Biotechnology & Applied Microbiology
Jiazi Gao, Pengling Ren, He Gong
Summary: This study investigated the morphological and mechanical changes in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs. The results showed that the micromechanical properties of articular cartilage were the lowest at 1 month of age, and the earliest degeneration of articular cartilage occurred at 6 months of age. No degeneration in the micro- or nanostructure of subchondral bone was observed before 9 months. These findings provide valuable insights into the formation and progression of hip osteoarthritis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tom D. Turmezei, Samantha B. Low, Simon Rupret, Graham M. Treece, Andrew H. Gee, James W. MacKay, John A. Lynch, Kenneth E. S. Poole, Neil A. Segal
Summary: Joint space mapping (JSM) of the knee using weight-bearing CT images is reproducible and feasible, showing a relationship between three-dimensional joint space width distribution and structural joint disease. Novice users can learn it reliably, and it can achieve a smallest detectable difference that is at least 50% smaller than that reported in radiography.
Article
Materials Science, Multidisciplinary
Sixiang Wang, Yan Gao, Lili Dong, Peixing Chen, Wanqian Liu, Li Yang
Summary: This study developed a novel drug delivery system targeting cartilage, which includes an ROS scavenger and an inflammatory-responsive nanocarrier. It was demonstrated that the nanocarrier exhibited excellent cartilage-targeting effects and ROS scavenging capacities, effectively suppressing angiogenesis and cartilage degradation, providing a promising therapeutic strategy for the treatment of OA and other inflammatory diseases characterized by oxidative stress and angiogenesis.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Haolan Zhang, Hao Xiong, Wajiha Ahmed, Yuejun Yao, Shuqin Wang, Cunyi Fan, Changyou Gao
Summary: The synthesis of a novel polythioketal urethane (PTKU) for scavenging excessive ROS was effective in treating OA, with excellent mechanical properties and the ability to be formulated into various formulations such as nanoparticles (NPs). PTKU@DEX NPs could effectively reduce ROS levels and alleviate oxidative stress damage, regulating macrophage ratio and promoting therapeutic outcomes of OA.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Physical
Zhaoyi Wang, Hao Xiong, Zihe Zhai, Yuejun Yao, Tong Zhou, Haolan Zhang, Cunyi Fan, Changyou Gao
Summary: In this study, ROS-scavenging nanoparticles were developed for the treatment of osteoarthritis. The nanoparticles exhibited slow degradation and prolonged ROS-elimination ability, allowing for long-term retention in the joints. Additionally, the nanoparticles demonstrated anti-inflammatory effects and protected against cartilage damage, effectively attenuating the progression of osteoarthritis.
Article
Chemistry, Physical
Zhaoyi Wang, Hao Xiong, Zihe Zhai, Yuejun Yao, Tong Zhou, Haolan Zhang, Cunyi Fan, Changyou Gao
Summary: In this study, ROS-scavenging nanoparticles were developed by crosslinking poly(propylene fumarate) and poly(thioketal). These nanoparticles were further modified with chondroitin sulfate and showed prolonged joint retention time, ROS elimination ability, and anti-inflammatory effects, protecting the articular surface erosion and attenuating osteoarthritis progression.
Article
Biotechnology & Applied Microbiology
Zengxin Jiang, Hao Wang, Zeng Zhang, Jianfeng Pan, Hengfeng Yuan
Summary: This study designed a nanocarrier that can regulate the delivery of therapeutic agents into chondrocytes using ROS responsiveness, and confirmed the exact biological mechanisms of this strategy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lin Liu, Pan Luo, Mingyi Yang, Jiachen Wang, Weikun Hou, Peng Xu
Summary: Knee osteoarthritis (KOA) is a common degenerative disease characterized by degeneration and damage of articular cartilage. Oxidative stress plays a key role in the pathogenesis of KOA, with overproduction of reactive oxygen species (ROS) causing cartilage degeneration. Synovitis and aging also contribute to the development of KOA.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Depeng Fang, Zainen Qin, Li Zheng, Pek Yin Michelle Yew, Xianfang Jiang, Dan Kai, Fangming Song, Jinmin Zhao
Summary: In this study, a ROS-responsive nanocomposite scaffold was fabricated to investigate its antioxidative, anti-inflammatory, and chondro-protective effects on osteoarthritis. The results showed that the nanofibers exhibited accelerated release of Pue in response to H2O2, and effectively inhibited ROS production and activated antioxidant enzymes. Additionally, the scaffold demonstrated a chondro-protective effect by suppressing MMP expression and attenuating cartilage erosion.
MATERIALS & DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Maria-Luisa Perez-Lozano, Annabelle Cesaro, Marija Mazor, Eric Esteve, Sabine Berteina-Raboin, Thomas M. Best, Eric Lespessailles, Hechmi Toumi
Summary: Osteoarthritis is a complex degenerative disease that disrupts joint homeostasis, leading to inflammation, cartilage degradation, and pain. Studies show that dietary components and natural products have potential for new therapeutic strategies. Current research is focused on natural-product-based treatments for osteoarthritis management.
Article
Medicine, Research & Experimental
Junlong Zhong, Bin Wang, Biao Wu, Jie Shang, Ning Jiang, Aiyong Cui, Yufeng Chen, Xianghe Xu, Huading Lu
Summary: This study found that Clock expression is up-regulated in OA cartilage and Clock knockdown can attenuate ROS-mediated chondrocyte senescence by restoring autophagic flux, providing a potential therapeutic target for OA.
Article
Veterinary Sciences
Silvia Fernandez-Martin, Antonio Gonzalez-Cantalapiedra, Maria Permuy, Mario Garcia-Gonzalez, Monica Lopez-Pena, Fernando Munoz
Summary: This study investigated the quantitative effect of long-term risedronate use on joint and subchondral bone in an experimental rabbit model, finding that it could not reduce the osteoarthritic hypertrophic cartilage response, nor prevent surface cartilage damage or trabecular bone loss.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Cell & Tissue Engineering
Min-Sun Son, Marc E. Levenston
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2017)
Article
Cell Biology
James F. Nishimuta, Monica F. Bendernagel, Marc E. Levenston
CONNECTIVE TISSUE RESEARCH
(2017)
Article
Physiology
Mona Eskandari, Alberto L. Arvayo, Marc E. Levenston
JOURNAL OF APPLIED PHYSIOLOGY
(2018)
Article
Orthopedics
Alberto L. Arvayo, Ivan J. Wong, Jason L. Dragoo, Marc E. Levenston
JOURNAL OF ORTHOPAEDIC RESEARCH
(2018)
Meeting Abstract
Orthopedics
L. Watkins, F. Kogan, E. Rubin, M. Black, M. Levenston, G. Gold
OSTEOARTHRITIS AND CARTILAGE
(2019)
Article
Orthopedics
A. L. Arvayo, A. Imbrie-Moore, M. E. Levenston
OSTEOARTHRITIS AND CARTILAGE
(2019)
Article
Orthopedics
Eva G. Baylon, Marc E. Levenston
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Article
Biophysics
Lauren E. Watkins, Elka B. Rubin, Valentina Mazzoli, Scott D. Uhlrich, Arjun D. Desai, Marianne Black, Gabe K. Ho, Scott L. Delp, Marc E. Levenston, Gary S. Beaupre, Garry E. Gold, Feliks Kogan
NMR IN BIOMEDICINE
(2020)
Article
Orthopedics
E. G. Baylon, H. A. Crowder, G. E. Gold, M. E. Levenston
OSTEOARTHRITIS AND CARTILAGE
(2020)
Article
Orthopedics
Hollis A. Crowder, Valentina Mazzoli, Marianne S. Black, Lauren E. Watkins, Feliks Kogan, Brian A. Hargreaves, Marc E. Levenston, Garry E. Gold
Summary: This study utilized quantitative MRI to observe short-term responses of healthy knee cartilage to running-induced loading, revealing changes in cartilage hydration and T-2 relaxation time.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Judith Zimmermann, Michael Loecher, Fikunwa O. Kolawole, Kathrin Baeumler, Kyle Gifford, Seraina A. Dual, Marc Levenston, Alison L. Marsden, Daniel B. Ennis
Summary: This study investigated the impact of aortic wall stiffness on hemodynamic characteristics using MRI technology and aortic models. The results showed that stiffer aortic models led to higher blood pressure, changes in velocity patterns, and increased PWV, while lower temporal resolution affected the estimation of peak velocity and PWV.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mary E. Hall, Marianne S. Black, Garry E. Gold, Marc E. Levenston
Summary: The study demonstrated the utility of a 2D watershed algorithm for accurately identifying cartilage boundaries in CT arthrograms of the knee, even with increasing boundary blurring. The results indicated that the watershed lines were closer to the cartilage surface in areas where soft tissues were in direct contact with each other.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Multidisciplinary Sciences
Mary E. Hall, Adam S. Wang, Garry E. Gold, Marc E. Levenston
Summary: The ability to derive contrast agent (CA) diffusivity from computed tomography arthrography (CTa) scans may serve as a biomarker for early degenerative changes. Experimental and computational approaches were used to study the factors influencing CTa-derived apparent diffusivity.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
N. Bennett, H. Zhang, K. Mueller, R. Fahrig, A. Maier, M. Levenston, G. Gold, A. Wang
Article
Imaging Science & Photographic Technology
Bastian Bier, Nishant Ravikumar, Mathias Unberath, Marc Levenston, Garry Gold, Rebecca Fahrig, Andreas Maier
JOURNAL OF IMAGING
(2018)