Article
Biochemistry & Molecular Biology
Layth Ben-Trad, Constantin Ionut Matei, Mirela Maria Sava, Samira Filali, Marie-Eve Duclos, Yves Berthier, Michel Guichardant, Nathalie Bernoud-Hubac, Ofelia Maniti, Ahmed Landoulsi, Marie-Genevieve Blanchin, Pierre Miossec, Thierry Granjon, Ana-Maria Trunfio-Sfarghiu
Summary: This study compares the biochemical, tribological, and ultrastructural properties of synovial fluid in healthy individuals and patients with osteoarthritis and arthritis, finding differences that indicate the importance of synovial fluid in joint mechanics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Jurgen T. Sanes, Catherine E. Costello, Allen C. Steere
Summary: This study compared the glycan profiles of total IgG1 and Borrelia burgdorferi (Bb)-specific IgG1 antibodies in patients with oral antibiotic-responsive or antibiotic-refractory Lyme arthritis (LA). The results showed that patients with oral antibiotic-responsive LA had more balanced proinflammatory/antiinflammatory glycan profiles, while patients with antibiotic-refractory LA had maximal, minimally opposed, proinflammatory glycan profiles.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rebecca Sohn, Marius Junker, Andrea Meurer, Frank Zaucke, Rainer H. Straub, Zsuzsa Jenei-Lanzl
Summary: The study showed that synoviocytes of OA and RA patients have the ability to synthesize adenosine/inosine, with adenosine predominantly responsible for the anti-inflammatory effects. Inhibiting CD73 increased IL-6 and decreased IL-10, while inhibiting ADA reduced IL-6 and induced IL-10. A(2A)- and A(2B)AR play a crucial role in mediating anti-inflammatory or pro-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chiara Baggio, Roberto Luisetto, Carlotta Boscaro, Anna Scanu, Roberta Ramonda, Mattia Albiero, Paolo Sfriso, Francesca Oliviero
Summary: Genomic damage is associated with autoimmune processes, chronic inflammation, and apoptosis. The T cell compartment may exhibit overall genomic instability in certain rheumatological diseases. However, there is limited knowledge regarding leukocyte abnormalities in synovial fluid (SF) and their connection to inflammation. This study aimed to investigate cellular phenotypes in SF from patients with various inflammatory arthropathies. The results showed that inflammatory SF is associated with genomic instability and abnormal cell subsets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Li Zheng, Fanlei Hu, Wenjie Bian, Yingni Li, Linqi Zhang, Lianjie Shi, Xiaoxu Ma, Yanying Liu, Xuewu Zhang, Zhanguo Li
Summary: Dkk-1 exacerbates inflammation, cartilage erosion, and angiogenesis mediated by synovial fibroblasts in RA. Modulation of DKK-1 expression may facilitate the development of novel strategies to control RA.
CLINICAL RHEUMATOLOGY
(2021)
Article
Cell Biology
Clara Cambria, Francesca Ingegnoli, Eleonora Borzi, Laura Cantone, Lavinia Agra Coletto, Alessandra Stefania Rizzuto, Orazio De Lucia, Sabrina Briguglio, Massimiliano Ruscica, Roberto Caporali, Valentina Bollati, Massimiliano Buoli, Flavia Antonucci
Summary: Arthritides is a group of diverse disorders that affect joints, including localized joint disorders and systemic autoimmune-driven diseases. Poor mental health is common among arthritides patients. Research has shown that extracellular vesicles derived from synovial fluid can affect neuronal function, and the concentration of synovial vesicles is associated with psychiatric symptoms in arthritides patients.
Article
Biochemistry & Molecular Biology
Djedjiga Ait Eldjoudi, Alfonso Cordero Barreal, Maria Gonzalez-Rodriguez, Clara Ruiz-Fernandez, Yousof Farrag, Mariam Farrag, Francisca Lago, Maurizio Capuozzo, Miguel Angel Gonzalez-Gay, Antonio Mera Varela, Jesus Pino, Oreste Gualillo
Summary: White adipose tissue is a specialized tissue involved in lipid synthesis and storage. It serves as an active organ that secretes hormones and cytokines called adipokines, with leptin being a key molecule. Leptin not only regulates energy balance and food intake, but also plays roles in reproduction, glucose metabolism, hematopoiesis, and immune system interactions. It is involved in innate and adaptive immunity and contributes to the pathogenesis of chronic inflammation and immune-related diseases like osteoarthritis and rheumatoid arthritis. This review summarizes recent findings on the involvement of leptin in immunity and inflammatory responses in these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Bin Zhao, Lingting Zeng, Danyang Chen, Songqing Xie, Zhaokui Jin, Guanglin Li, Wei Tang, Qianjun He
Summary: This study proposes a concept of photocatalytic regulation of the synovial microenvironment (SME) for arthritis treatment. Monodispersive hydrogen-doped titanium dioxide nanorods with a rutile single-crystal structure are developed to achieve near infrared-photocatalytic generation of hydrogen molecules and depletion of lactic acid (LA) in a collagen-induced mouse model of rheumatoid arthritis. The results show that locally produced hydrogen molecules scavenge reactive oxygen species and regulate the synovial microenvironment, thereby preventing synovial pannus formation and cartilage destruction.
Article
Multidisciplinary Sciences
Shintaro Mishima, Jun-ichi Kashiwakura, Shota Toyoshima, Tomomi Sasaki-Sakamoto, Yutaka Sano, Kazuyoshi Nakanishi, Kenji Matsumoto, Yoshimichi Okayama
Summary: Synovial mast cells from rheumatoid arthritis patients have been found to produce significantly more PGD(2) compared to osteoarthritis patients; the PGD(2) induced IL-8 production by innate lymphoid cells, suggesting a mechanism for neutrophil recruitment in RA synovium; miRNA-199a-3p may play a role in down-regulating PTGS2 in RA patients' mast cells.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Falk Nimmerjahn, Gestur Vidarsson, Mark S. Cragg
Summary: Humoral immune responses generate polyclonal antibodies with varied isotypes, epitope specificity, and affinity. Posttranslational modifications in antibody variable and constant domains can modify antigen specificity and antibody Fc-dependent functions. Understanding the impact of these modifications on antibody function is still limited, but it has implications for therapeutic antibody development. This Review provides insights into how IgG subclass and posttranslational modifications influence antibody activity and discusses their implications in designing therapeutic antibodies for different clinical indications.
Article
Orthopedics
Anne-Mari Mustonen, Janne Capra, Kirsi Rilla, Petri Lehenkari, Sanna Oikari, Tommi Kaariainen, Antti Joukainen, Heikki Kroger, Tommi Paakkonen, Johanna Matilainen, Petteri Nieminen
Summary: The study successfully developed a method for quantifying EV, HA particles, and HA-EV in human knee joint SF using CLSM and image analysis. The results showed that the fluorescence intensities of EV and HA particles were lower in RA patients compared to the control group and OA group, indicating potential implications for diagnosis and therapy in rheumatoid arthritis SF.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Editorial Material
Rheumatology
Camilla R. L. Machado, Gary S. Firestein
Summary: Rheumatoid arthritis synovium contains fibroblast-like synoviocytes that are phenotypically and functionally heterogeneous. Advanced analyses have identified at least four distinct cell states, which are determined by the cells' location in the synovium, epigenetic imprinting, and the influence of microenvironment mediators.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Immunology
Alzahraa Abdelwahab, Sanna Palosaari, Soha Abdelkawy Abdelwahab, Rehab Ahmed Rifaai, Nashwa Fathy El-Tahawy, Entesar Ali Saber, Tomi Nousiainen, Maarit Valkealahti, Johanna Huhtakangas, Tuomo J. Karttunen, Petri Lehenkari
Summary: Research on synovial tissue expression of Toll-like receptors (TLRs) in rheumatoid arthritis (RA) showed differences between seropositive and seronegative RA, potentially impacting disease outcomes. High expression of specific TLRs in seropositive RA may prime the synovium for reactions to citrullinated proteins and nucleic acids, which could contribute to inflammation.
Article
Rheumatology
Raphael Micheroli, Muriel Elhai, Sam Edalat, Mojca Frank-Bertoncelj, Kristina Buerki, Adrian Ciurea, Lucy MacDonald, Mariola Kurowska-Stolarska, Myles J. Lewis, Katriona Goldmann, Cankut Cubuk, Tadeja Kuret, Oliver Distler, Costantino Pitzalis, Caroline Ospelt
Summary: This study integrated single-cell RNA sequencing data to assess the contribution of synovial fibroblast subsets to synovial pathotypes and clinical characteristics in treatment-naive early arthritis. The findings revealed a previously unexplored association between specific synovial pathologies and subtypes of synovial fibroblasts.
Article
Biochemistry & Molecular Biology
Ayumi Tsukada, Ken Takata, Shotaro Takano, Yoshihisa Ohashi, Manabu Mukai, Jun Aikawa, Dai Iwase, Gen Inoue, Masashi Takaso, Kentaro Uchida
Summary: This study compared the relationship between obesity risk factors and knee osteoarthritis in obese and normal weight patients, revealing significant expression differences. It was found that NMUR1 expression was elevated in obese patients, and NMU/NMUR1 expression was detected in MCs, potentially providing a link between obesity and KOA pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Toshiaki Hirakata, Hyeon-Cheol Lee, Mai Ohba, Kazuko Saeki, Toshiaki Okuno, Akira Murakami, Akira Matsuda, Takehiko Yokomizo
Article
Allergy
Akira Matsuda, Yosuke Asada, Naomasa Suita, Satoshi Iwamoto, Toshiaki Hirakata, Norihiko Yokoi, Yasuyuki Ohkawa, Yukinori Okada, Takehiko Yokomizo, Nobuyuki Ebihara
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Allergy
Yosuke Asada, Mikiko Okano, Waka Ishida, Satoshi Iwamoto, Ken Fukuda, Toshiaki Hirakata, Norihiro Tada, Atsuki Fukushima, Nobuyuki Ebihara, Akira Kudo, Akira Matsuda
ALLERGOLOGY INTERNATIONAL
(2019)
Article
Ophthalmology
Rio Honda, Toshimitsu Kasuga, Akira Murakami, Akira Matsuda
CURRENT EYE RESEARCH
(2019)
Article
Ophthalmology
Toshimitsu Kasuga, Satoko Asaoka, Yosuke Asada, Satoshi Iwamoto, Toshiaki Hirakata, Rio Honda, Toshihiko Ohta, Akira Matsuda
JOURNAL OF GLAUCOMA
(2020)
Article
Biochemistry & Molecular Biology
Hirotoshi Unno, Ken Arae, Akira Matsuda, Masashi Ikutani, Masato Tamari, Kenichiro Motomura, Sumika Toyama, Hajime Suto, Ko Okumura, Akio Matsuda, Hideaki Morita, Katsuko Sudo, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Review
Biochemistry & Molecular Biology
Toshiaki Hirakata, Akira Matsuda, Takehiko Yokomizo
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2020)
Article
Multidisciplinary Sciences
Keisuke Adachi, Yosuke Asada, Toshiaki Hirakata, Miki Onoue, Satoshi Iwamoto, Toshimitsu Kasuga, Akira Matsuda
SCIENTIFIC REPORTS
(2020)
Article
Ophthalmology
Keitaro Mashimo, Ayumi Usui-Ouchi, Yousuke Ito, Rei Wakasa-Arai, Norihiko Yokoi, Satoshi Kawasaki, Akira Murakami, Akira Matsuda, Nobuyuki Ebihara
Summary: The study found that the concentration of OSM in the tear fluid of VKC patients was higher than that of healthy controls, and strong expression of OSM mRNA was found in giant papillae. T cells expressing OSM were also detected in giant papillae, as well as surface expression of OSMR beta in HconEpiCs. Recombinant human OSM strongly activated both STAT1 and STAT3 in HconEpiCs, inducing the expression of various tissue remodeling-related genes.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Allergy
Shota Toyoshima, Tomomi Sakamoto-Sasaki, Yusuke Kurosawa, Koremasa Hayama, Akira Matsuda, Yasuo Watanabe, Tadashi Terui, Yasuhiro Gon, Kenji Matsumoto, Yoshimichi Okayama
Summary: The study revealed that EVs derived from MCs can activate ILC2s through miR103a-3p, leading to increased production of IL-5 and exacerbating eosinophilic allergic inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Ophthalmology
Satoko Asaoka, Toshimitsu Kasuga, Toru Matsunaga, Yusuke Hayashi, Yosuke Asada, Satoshi Iwamoto, Toshiaki Hirakata, Rio Honda, Hanako Obazawa, Hidenori Sasaki, Toshihiko Ohta, Akira Matsuda
Summary: In this study, it was found that malposition of the tube was more common with the Ahmed glaucoma valve compared to the Baerveldt drainage implant. Insertion of the tube through the ciliary sulcus was effective in controlling intraocular pressure, but early postoperative complications were more common with the AGV treatment.
JOURNAL OF GLAUCOMA
(2021)
Editorial Material
Allergy
Akira Matsuda
ALLERGOLOGY INTERNATIONAL
(2022)
Review
Allergy
Dai Miyazaki, Atsuki Fukushima, Eiichi Uchio, Jun Shoji, Kenichi Namba, Nobuyuki Ebihara, Etsuko Takamura, Ken Fukuda, Akira Matsuda, Shigeki Okamoto, Kazumi Fukagawa, Hiroshi Fujishima, Shigeaki Ohno, Yuichi Ohashi
Summary: This article summarizes the third edition of the Japanese guidelines for allergic conjunctival diseases, outlining the diagnosis, pathogenesis, and treatment of ACD, with a focus on the use of steroids and immunosuppressive drugs. This knowledge will assist healthcare providers and patients in making informed decisions regarding treatment.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Euido Nishijima, Sari Honda, Yuta Kitamura, Kazuhiko Namekata, Atsuko Kimura, Xiaoli Guo, Yuriko Azuchi, Chikako Harada, Akira Murakami, Akira Matsuda, Tadashi Nakano, Luis F. Parada, Takayuki Harada
Summary: In this study, a system was developed to achieve constitutive activation of iTrkB without ligands, by forcing its membrane localization. This system overcomes the limitations of packaging size in AAV and allows high expression of the transgene. Using gene therapy in the eyes, it was shown that iTrkB expression enhances neuroprotection and stimulates axon regeneration in mouse models of glaucoma and optic nerve injury. The system could potentially be applied to other trophic factor signaling pathways and advance the field of gene therapy for neuro-trauma and neurodegenerative disorders, including glaucoma.
Article
Ophthalmology
Sari Honda, Kazuhiko Namekata, Atsuko Kimura, Xiaoli Guo, Chikako Harada, Akira Murakami, Akira Matsuda, Takayuki Harada
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)