Review
Medicine, General & Internal
William G. Ambler, Kabita Nanda, Karen Brandt Onel, Susan Shenoi
Summary: This review focuses on the treatment options and potential future therapeutics for systemic juvenile idiopathic arthritis (SJIA). Recent advancements in targeted therapies have improved patient outcomes, but there are still subsets of patients with refractory disease and severe complications.
ANNALS OF MEDICINE
(2022)
Article
Rheumatology
Stephane Mitrovic, Nolan Hassold, Aly Kamissoko, Nicolas Rosine, Alexis Mathian, Guillaume Mercy, Edouard Pertuiset, Gaetane Nocturne, Bruno Fautrel, Isabelle Kone-Paut
Summary: A retrospective national survey revealed features of SpA in patients with SJIA/AOSD, with a prevalence of 6.58% in AOSD patients and 10% in SJIA patients. This suggests a possible overlap between SpA and AOSD that requires further study.
Article
Rheumatology
Piero Ruscitti, Valentina Natoli, Alessandro Consolaro, Roberta Caorsi, Silvia Rosina, Gabriella Giancane, Roberta Naddei, Ilenia Di Cola, Claudia Di Muzio, Onorina Berardicurti, Daniela Iacono, Ilenia Pantano, Gelsomina Rozza, Silvia Rossi, Ludovico De Stefano, Silvia Balduzzi, Antonio Vitale, Francesco Caso, Luisa Costa, Marcella Prete, Luca Navarini, Annamaria Iagnocco, Fabiola Atzeni, Giuliana Guggino, Federico Perosa, Luca Cantarini, Bruno Frediani, Carlomaurizio Montecucco, Francesco Ciccia, Paola Cipriani, Marco Gattorno, Roberto Giacomelli, Angelo Ravelli
Summary: This study compares the clinical features and treatments of systemic JIA and adult-onset Still's disease. The results reveal remarkable disparities in the prevalence of clinical manifestations between the two illnesses, which may partly depend on their classification by different criteria.
Article
Cardiac & Cardiovascular Systems
R. Mark Grady, Matthew W. Canter, Fei Wan, Anton A. Shmalts, Ryan D. Coleman, Maurice Beghetti, Rolf M. F. Berger, Maria J. del Cerro Marin, Scott E. Fletcher, Russel Hirsch, Tilman H. Umpl, D. Dunbar Ivy, Edward C. Kirkpatrick, Thomas J. Kulik, Marilyne Levy, Shahin Moledina, Delphine Yung, Pirooz Eghtesady, Damien Bonnet
Summary: Pulmonary-to-systemic arterial shunt surgery provides significant clinical improvement for children with severe PH, with high survival rates after discharge, while children at high risk in-hospital are not suitable candidates for the procedure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Camille Beaufils, Catherine Proulx, Annaliesse Blincoe, Pierre Teira, Henrique Bittencourt, Sonia Cellot, Michel Duval, Marie-Paule Morin, Jean Jacques De Bruycker, Julie Couture, Kathryn Samaan, Helene Decaluwe, Niina Kleiber, Ramy El-Jalbout, Fabien Touzot, Elie Haddad, Julie Barsalou
Summary: This study reports cases of systemic-onset juvenile idiopathic arthritis (sJIA) patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) and reviews published outcomes of allo-HSCT in sJIA. The results indicate that allo-HSCT may be a potential curative option for severe/refractory sJIA.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Menglan Zhang, Leiwen Peng, Wensheng Li, Yifei Duan, Xiaoqin Liu, Shasha Chen, Jiamin Deng, Xinle Liu
Summary: This study found that IL12B polymorphisms are associated with the susceptibility of JIA and JSLE in Chinese children. The rs3212227 genotype is significantly associated with an increased risk of JSLE, while the rs6887695 genotype is significantly associated with an increased risk of JIA. Additionally, the IL12B haplotype GC is significantly associated with an increased risk of JIA. However, there is no significant difference in the IL17 gene polymorphisms between JIA and JSLE susceptibility.
Article
Multidisciplinary Sciences
Tingyan He, Jiayun Ling, Jun Yang
Summary: This study describes the incidence of TCZ-induced hypofibrinogenemia in SJIA patients and its possible influence on bleeding risk.
SCIENTIFIC REPORTS
(2023)
Article
Pediatrics
Hikaru Kanemasa, Etsuro Nanishi, Hidetoshi Takada, Masataka Ishimura, Hisanori Nishio, Satoshi Honjo, Hiroshi Masuda, Noriko Nagai, Takahiro Nishihara, Tohru Ishii, Takenori Adachi, Satoshi Hara, Lisheng Lin, Yoshie Tomita, Junji Kamizono, Osamu Komiyama, Urara Kohdera, Saori Tanabe, Atsuo Sato, Shinya Hida, Mayumi Yashiro, Nobuko Makino, Yosikazu Nakamura, Toshiro Hara, Shouichi Ohga
Summary: Arthritis requiring treatment is a rare complication of KD, with two main types being interval-type (KD-reactive) and continued-type (true systemic-onset juvenile idiopathic arthritis [JIA] requiring biologics). Interval-type patients often do not require biologics for arthritis control and have a higher 2-year off-treatment rate.
FRONTIERS IN PEDIATRICS
(2021)
Article
Rheumatology
Rosemary G. Peterson, Rui Xiao, Karen E. James, Hannah Katcoff, Brian T. Fisher, Pamela F. Weiss
Summary: The study found significant variation in the use of biologics and glucocorticoids in children hospitalized with new-onset systemic JIA, with noticeable differences between hospitals. Despite increasing evidence supporting the use of biologics for improved outcomes, many children did not receive biologic treatment and a high rate of glucocorticoid exposure persisted.
ARTHRITIS CARE & RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Ji-Won Kim, Mi-Hyun Ahn, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
Summary: Neutrophils are crucial immune cells that defend against pathogens through mechanisms such as phagocytosis and formation of neutrophil extracellular traps (NETs). While NETs can kill pathogens, they may also cause toxic effects in hosts and trigger autoimmune responses in susceptible individuals, contributing to various inflammatory autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yu Peng, Xiaohui Liu, Zhao Duan, Junkai Duan, Yulan Zhou
Summary: The study showed that patients with SoJIA have significantly higher levels of IL-10 compared to other febrile diseases. IL-10 levels were found to be closely associated with disease activity and disease courses in SoJIA, and were superior in predicting disease patterns compared to other biomarkers.
MEDIATORS OF INFLAMMATION
(2021)
Article
Rheumatology
Hao-Guang Li, Dan-Min Wang, Feng-Cai Shen, Shu-Xin Huang, Zhi-Duo Hou, Ling Lin, Zheng-Yu Xiao
Summary: Peripheral involvement is common in juvenile-onset non-radiographic axial spondyloarthritis, and risk factors associated with progression to juvenile-onset ankylosing spondylitis include inflammatory back pain, buttock pain, enthesitis, elevated baseline CRP levels, and sacroiliac joint-MRI positivity.
Review
Medicine, General & Internal
Judith A. Smith, Ruben Burgos-Vargas
Summary: Some studies suggest that children with juvenile onset spondyloarthritis have a relatively poor outcome compared to other juvenile idiopathic arthritis categories, but new therapies such as TNF inhibitors offer hope for improving disease prognosis.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Jonathan C. Li, Sameh Tadros, Franziska Rosser, Kathryn S. Torok
Summary: This study found that 31% of juvenile systemic sclerosis patients have pulmonary nodules, which have heterogeneous characteristics and remain stable over time. Clinical associations with the presence of nodules include structural esophageal abnormalities, restriction, and reduced diffusing capacity on lung function tests. These findings highlight the need for radiologic follow-up and clinical management of pulmonary nodules in juvenile systemic sclerosis patients.
Article
Medicine, General & Internal
Monika Szturmowicz, Monika Franczuk, Malgorzata Ewa Jedrych, Dorota Wyrostkiewicz, Karina Oniszh, Szymon Darocha, Krzysztof Kasperowicz, Marcin Kurzyna
Summary: Chronic lung diseases are a common cause of pulmonary hypertension, with the challenge lying in differentiating between PH due to lung disease and PAH with coexisting lung disease. The dominant cause of PH can change over time, necessitating new diagnostic procedures and treatment modalities. Coordination between pulmonologists and cardiologists is crucial for successful treatment in patients with lung diseases.