Article
Biology
Maren Kasper, Michael Heming, David Schafflick, Xiaolin Li, Tobias Lautwein, Melissa Meyer zu Horste, Dirk Bauer, Karoline Walscheid, Heinz Wiendl, Karin Loser, Arnd Heiligenhaus, Gerd Meyer zu Hoerste
Summary: Uveitis is a group of inflammatory eye diseases characterized by infiltration of leukocytes into the uveal tissues. HLA-B27-positive uveitis displays a unique pattern of ocular leukocyte infiltration with a prominent presence of plasmacytoid and classical dendritic cells. These cells play a central role in predicted local cell-cell communication within the eye, suggesting their importance in HLA-B27-associated inflammation.
Article
Multidisciplinary Sciences
Tae Seen Kang, Yeongseop Lee, Seongjin Lee, Kyonghoon Kim, Woong-sub Lee, Woohyuk Lee, Jin Hyun Kim, Yong Seop Han
Summary: This study investigated the automated analysis of anterior chamber cell images using spectral domain OCT and its comparison with the SUN grading system. Results showed a strong correlation between the two methods, with significant differences observed in cell density, size, and eccentricity in different eye conditions. Despite limitations, anterior segment SD-OCT proves to be a reliable, fast, and accurate means of anterior chamber cell analysis.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Guomin Jiang, Juan Yun, Henry J. Kaplan, Yuan Zhao, Deming Sun, Hui Shao
Summary: Circulating exosomes have immunoregulatory functions in autoimmune uveitis, selectively inhibiting immune responses of specific T cells and reducing the incidence of recurrent uveitis in an antigen-specific manner. This suggests the potential for circulating exosomes to be a novel treatment for recurrent autoimmune uveitis.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Nikola Smatlik, Nourhan Mortada, Martin Roecken, Amir S. Yazdi, Manfred Zierhut
Summary: The study revealed the inhibitory effect of 5-ASA on proinflammatory cytokines in PBMCs of patients with HLA-B27+ and HLA-B27- acute anterior uveitis. The results showed similarities between the two types of AAU but did not explain how HLA-B27 status affects the therapeutic response to 5-ASA.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Medicine, General & Internal
Hiroshi Keino, Takuto Aman, Ryota Furuya, Makiko Nakayama, Annabelle A. Okada, Wataru Sunayama, Yuji Hatanaka
Summary: This study aimed to develop an automated method for evaluating anterior chamber (AC) cells in uveitis using optical coherence tomography (OCT) images. By analyzing the images with software and an automated algorithm, approximate AC grading values were obtained based on the correlation with Standardization of Uveitis Nomenclature (SUN) grading scores. The results showed significant correlations between the automated cellular spots analysis and the clinical scores, providing continuous AC grading values. This method improves the accuracy of quantitative assessment and allows objective and rapid evaluation of anterior segment inflammation in uveitis.
Article
Ophthalmology
Srinivasan Sanjay, G. C. Yathish, Yogeshpreet Singh, Ankush Kawali, Padmamalini Mahendradas, Rohit Shetty
Summary: A case report of a 35-year-old Asian Indian female with recurrent uveitis following COVID-19 vaccination is presented. The patient had a history of uveitis and was on oral methotrexate. The uveitis resolved with immunosuppression after COVID-19 infection, but recurred after vaccination.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Rheumatology
Cristiana Sieiro Santos, Isabel Sendino-Tenorio, Carolina Alvarez Castro, Clara Moriano Morales, Miguel Cordero Coma, Elvira Diez Alvarez
Summary: This study aimed to develop an outcome score SpA-U for evaluating the efficacy and refractoriness to treatment in patients with uveitis associated with spondylarthritis (SpA), and to determine factors associated with adverse outcomes in these patients.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2023)
Article
Ophthalmology
Francois Pepin, Joanne L. Sims, Rachael L. Niederer
Summary: This study evaluated the characteristics of anterior uveitis in patients with poorly controlled diabetes mellitus and no other identifiable cause. The results showed that poorly controlled diabetes could be associated with acute anterior uveitis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Mohammad Zarei, Tahereh Mahmoudi, Hamid Riazi-Esfahani, Behnam Mousavi, Nazanin Ebrahimiadib, Mehdi Yaseri, Elias Khalili Pour, Hossein Arabalibeik
Summary: Fuchs uveitis is a chronic eye inflammation with characteristic iris atrophic changes. Researchers have used AS-OCT images to study these changes, introducing automated methods to measure iris smoothness index that show good agreement with manual methods.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Jin A. Choi, Hyun-Hee Ju, Jiyoung Lee, Ju-Eun Kim, Soon-Young Paik, Nikolai P. Skiba, Ponugoti Vasantha Rao
Summary: Herpetic anterior uveitis-associated ocular inflammation often leads to ocular hypertension and glaucoma. Compared to other viruses, cytomegalovirus (CMV) positive hypertensive anterior uveitis is associated with high uveitis recurrence rates, uncontrolled intraocular pressure, and a higher need for future glaucoma surgery. Proteome analysis of aqueous humor from CMV-HAU patients revealed an increase in complement factor-associated inflammation and humoral immunity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Srinivasan Sanjay, Ankush Kawali, Padmamalini Mahendradas
Summary: A 36-year-old Asian Indian male with a history of dengue hepatitis and HLA-B27 spondyloarthropathy presented with recurrent anterior uveitis after recovery from COVID-19, COVID-19 vaccination, and dengue fever-associated hepatitis. Molecular mimicry and bystander activation are proposed as the mechanisms for the re-activation of anterior uveitis. Mild ocular inflammation following vaccination should not deter individuals from getting COVID-19 vaccination.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yacine Troumani, Sara Touhami, Timothy L. Jackson, Camila V. Ventura, Dinu Michel Stanescu-Segall, Marie-Helene Errera, Dominique Rousset, Bahram Bodaghi, Guilhem Cartry, Thierry David, Laurence Beral
Summary: This study found that almost half of patients with systemic Zika virus infection presented with red eyes and anterior uveitis, with a significant proportion experiencing persistently increased intraocular pressure. Ophthalmic evaluation should be considered in patients with red eye and acute Zika infection to potentially detect and manage hypertensive anterior uveitis.
JAMA OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Martin Arman Sorkhabi, Ivan O. Potapenko, Tomas Ilginis, Mark Alberti, Javier Cabrerizo
Summary: This study developed an automated AI-based method to quantify inflammation in the anterior chamber (AC) using AS-OCT and found a significant correlation between AI-assisted AS-OCT based inflammation analysis and clinical grading of anterior uveitis. The AI software accurately segmented AC boundaries and detected particles within the AC borders, showing potential application in early detection and management of anterior uveitis.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Avik Shome, Odunayo O. Mugisho, Rachael L. Niederer, Ilva D. Rupenthal
Summary: Uveitis is a complex ocular inflammatory disease that can be caused by infections or autoimmune factors. While infectious uveitis can often be resolved with anti-infective therapy and corticosteroids, non-infectious uveitis requires a better understanding of inflammatory pathways to develop more effective treatments.
DRUG DISCOVERY TODAY
(2021)
Review
Immunology
Denis Wakefield, Daniel Clarke, Peter McCluskey
Summary: Over the past 5 years, there has been steady progress in understanding the pathogenesis, clinical features, and treatment of acute anterior uveitis (AU). Large gene wide association studies have confirmed AU as a polygenic disease with overlaps with other conditions. Recent research has shown the importance of the microbiome in AU, with evidence suggesting that HLA B27 may influence gut microbiome composition. Clinical investigations have confirmed the typical features of AU and the value of immunosuppressive treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Jordi Gratacos, Jose L. Pablos, Eugenio de Miguel, Xavier Juanola, Cristina Fernandez-Carballido, Rafael Ariza, Pau Terradas-Montana, Carlos Sastre, Cristina Sanabra
Summary: The MiDAS study assessed the percentage of PsA patients achieving control of disease activity in routine clinical practice. The study showed that around 40% of PsA patients had uncontrolled disease, highlighting the need for improved management.
REUMATOLOGIA CLINICA
(2023)
Article
Rheumatology
Irene Monjo Henry, E. Fernandez Fernandez, D. Peiteado, A. Balsa, E. de Miguel
Summary: This study evaluated the added value of including large vessels (LV) in the diagnosis of giant cell arteritis (GCA) using color Doppler ultrasound (CDUS). The results showed that adding LV to the CDUS significantly improved the diagnostic accuracy of GCA. However, more than 12% of patients had isolated LV involvement, suggesting that CDUS examination for GCA should include both temporal arteries (TA) and LV.
CLINICAL RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Cristina Macia-Villa, Eugenio De Miguel
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Vicente Javier Clemente-Suarez, Alexandra Martin-Rodriguez, Rodrigo Yanez-Sepulveda, Jose Francisco Tornero-Aguilera
Summary: Mitochondrial dysfunction is a common feature of various diseases, and mitochondrial transfer has emerged as a potential therapeutic approach for restoring mitochondrial function. This review summarizes the current understanding of mitochondrial transfer, its mechanisms, therapeutic applications, and impact on cell death pathways. The future directions and challenges in using mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Eugenio De Miguel, Pierluigi Macchioni, Edoardo Conticini, Corrado Campochiaro, Rositsa Karalilova, Sara Monti, Cristina Ponte, Giulia Klinowski, Irene Monjo-Henry, Paolo Falsetti, Zguro Batalov, Alessandro Tomelleri, Alojzija Hocevar
Summary: The objective of this study was to analyze the prevalence and characteristics of subclinical giant cell arteritis (GCA) in patients with polymyalgia rheumatica (PMR). The researchers used ultrasound to examine multiple arteries of PMR patients and found some of them had subclinical GCA. Patients with subclinical GCA were older, had longer morning stiffness duration, and more frequently reported hip pain compared to those without subclinical GCA. The optimal screening strategy to detect vasculitis in PMR needs further investigation.
Review
Nutrition & Dietetics
Vicente Javier Clemente-Suarez, Maria Isabel Ramirez-Goerke, Laura Redondo-Florez, Ana Isabel Beltran-Velasco, Alexandra Martin-Rodriguez, Domingo Jesus Ramos-Campo, Eduardo Navarro-Jimenez, Rodrigo Yanez-Sepulveda, Jose Francisco Tornero-Aguilera
Summary: Anorexia nervosa is a psychiatric disorder characterized by an individual's preoccupation with weight and body structure while denying the severity of low body weight. Non-pharmacological interventions, such as nutritional, physical activity, psychological, psychosocial, and physical therapy interventions, can be used to ameliorate or reduce the symptoms of this condition.
Review
Nutrition & Dietetics
Vicente Javier Clemente-Suarez, Ana Isabel Beltran-Velasco, Laura Redondo-Florez, Alexandra Martin-Rodriguez, Jose Francisco Tornero-Aguilera
Summary: The Western diet, characterized by high consumption of pre-packaged foods, red meat, sugary drinks, and fried foods, has significant effects on metabolism, inflammation, antioxidant status, gut microbiota, mitochondrial fitness, cardiovascular health, mental health, and cancer. A critical review was conducted using primary and secondary sources to provide a comprehensive understanding of this dietary pattern's impact on individuals' health and national healthcare systems. Practical applications based on the findings were also suggested.
Review
Nutrition & Dietetics
Vicente Javier Clemente-Suarez, Alvaro Bustamante-Sanchez, Juan Mielgo-Ayuso, Ismael Martinez-Guardado, Alexandra Martin-Rodriguez, Jose Francisco Tornero-Aguilera
Summary: The role of reactive oxygen species (ROS) and antioxidants in sports performance and training adaptations is investigated. The review discusses the production of ROS during physical activity, the effects of ROS on sports performance, the relationship between ROS and training adaptations, inflammation, and microbiota, the influence of antioxidants on recovery and sports performance, and strategies for using antioxidant supplements. Practical applications derived from this information are also discussed.
Article
Chemistry, Multidisciplinary
Jesus Diaz-Garcia, Vicente Javier Clemente-Suarez, Juan Pedro Fuentes-Garcia, Santos Villafaina
Summary: This study compared the effects of single High-Intensity Interval Training (HIIT) and combining HIIT with an incongruent Stroop task on mental and physical fatigue indicators. The results showed that combining the Stroop task with HIIT increased mental fatigue and perceived exertion, but did not affect external (speed) and internal (heart rate) factors. This suggests that mental fatigue can increase the subjective perception of physical exertion, but does not decrease the physical workload during HIIT for tennis players.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Vicente Javier Clemente-Suarez, Laura Redondo-Florez, Ana Isabel Beltran-Velasco, Alexandra Martin-Rodriguez, Ismael Martinez-Guardado, Eduardo Navarro-Jimenez, Carmen Cecilia Laborde-Cardenas, Jose Francisco Tornero-Aguilera
Summary: Adipokines are proteins secreted by adipose tissue and have been associated with low-grade inflammation and various diseases. This review aims to analyze the role of adipokines in health and disease, specifically focusing on their functions, relationships to inflammation and different diseases, and the influence of microbiota, nutrition, and physical activity. Understanding the effects of these important cytokines on the body is essential.
Article
Rheumatology
Eugenio De Miguel, Rositsa Karalilova, Pierluigi Macchioni, Cristina Ponte, Edoardo Conticini, Sharon Cowley, Alessandro Tomelleri, Sara Monti, Irene Monjo, Zguro Batalov, Giulia Klinowski, Paolo Falsetti, David J. Kane, Corrado Campochiaro, Alojzija Hocevar
Summary: The aim of this study was to assess the clinical significance of subclinical giant cell arteritis (GCA) in polymyalgia rheumatica (PMR) and determine the optimal treatment approach. Results showed that PMR patients with subclinical GCA had a higher rate of relapse during a 2-year follow-up compared to those with isolated PMR. Lower starting doses of glucocorticoids and rapid tapering within the first 3 months were identified as risk factors for relapse.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Vicente Javier Clemente-Suarez, Alexandra Martin-Rodriguez, Laura Redondo-Florez, Clara Lopez-Mora, Rodrigo Yanez-Sepulveda, Jose Francisco Tornero-Aguilera
Summary: Endocrine homeostasis and metabolic diseases have been extensively researched, leading to a deeper understanding of their mechanisms and new approaches to diagnosis and treatment. This review discusses the rise of metabolic diseases, their genetic, psychological, and behavioral basis, the role of nutrition and physical activity, as well as advanced techniques and therapies in addressing these diseases. Practical applications derived from this information are also highlighted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Vicente Javier Clemente-Suarez, Ana Isabel Beltran-Velasco, Laura Redondo-Florez, Alexandra Martin-Rodriguez, Rodrigo Yanez-Sepulveda, Jose Francisco Tornero-Aguilera
Summary: This comprehensive narrative review explores the concept of neuro-vulnerability in energy metabolism regulation and its implications for metabolic disorders. The review highlights the complex interactions among the neural, hormonal, and metabolic pathways involved in the regulation of energy metabolism. It investigates the association between neuro-vulnerability and metabolic disorders, considering genetic, epigenetic, and environmental factors that influence neuro-vulnerability and subsequent metabolic dysregulation. The review also evaluates the use of neuroimaging techniques in studying neuro-vulnerability and their potential applications in clinical settings.
Article
Chemistry, Multidisciplinary
Pedro Belinchon-deMiguel, Domingo Jesus Ramos-Campo, Vicente Javier Clemente-Suarez
Summary: Physical activity and excessive caloric intake are major contributors to chronic diseases. Recreating the hunter-gatherer lifestyle through physical activity and caloric restriction can potentially improve overall health. In this study, a fasting participant showed higher perceived exertion, stress, pain, and dehydration during a 4-day walking event. They also experienced poorer sleep quality, increased creatinine kinase levels, and decreased lower limb strength.
APPLIED SCIENCES-BASEL
(2023)
Review
Cell Biology
Vicente Javier Clemente-Suarez, Alexandra Martin-Rodriguez, Laura Redondo-Florez, Carlota Valeria Villanueva-Tobaldo, Rodrigo Yanez-Sepulveda, Jose Francisco Tornero-Aguilera
Summary: This comprehensive review explores the pathophysiological mechanisms of epithelial transport and its significance in disease pathogenesis. It covers different forms of transport, genetic disorders, and the role of epithelial transport in common diseases. The review also highlights the potential for future therapeutic interventions in conditions such as cystic fibrosis, hypertension, and renal failure.