Article
Cell & Tissue Engineering
H-T. Liao, C-Y. Tsai
Summary: The aim of this study was to investigate the correlations among cytokines and regulatory T cells (T-regs) in ankylosing spondylitis (AS) patients, as well as their changes after anti-tumour necrosis factor-alpha (TNF-alpha) treatment. The results showed that the frequency of T-regs in peripheral blood was positively correlated to disease activity indices and inflammatory markers in AS patients. After TNF-alpha treatment, there was a significant decrease in TNF-alpha levels, IL-10 levels, TGF-beta levels, and frequency of T-regs in peripheral blood of AS patients.
BONE & JOINT RESEARCH
(2023)
Review
Immunology
Yanyan Fang, Jian Liu
Summary: Ankylosing spondylitis (AS) is a type of arthritis that primarily affects the spine and involves disorders of the immune and skeletal systems. Non-coding RNAs (ncRNAs), particularly long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and micro RNAs (miRNAs), play regulatory roles in AS cell functions and can be used for AS diagnosis and treatment. Understanding the role of ncRNAs in the pathogenesis of AS will contribute to the development of new therapeutic approaches for AS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Zeyang Chen, Yanan Zhang, Joanne Kwak-Kim, Wenjuan Wang
Summary: Maternal immune tolerance to embryos is crucial in pregnancy, and memory T cells play a critical role in this process. Dysfunction of memory T cells is associated with various pregnancy complications. Therefore, understanding the differentiation and characteristics of memory T cells, as well as their role in pregnancy, is of great importance for diagnosing and treating pregnancy-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ekaterina A. Komech, Anastasia D. Koltakova, Anna A. Barinova, Anastasia A. Minervina, Maria A. Salnikova, Evgeniya I. Shmidt, Tatiana V. Korotaeva, Elena Y. Loginova, Shandor F. Erdes, Ekaterina A. Bogdanova, Mikhail Shugay, Sergey Lukyanov, Yury B. Lebedev, Ivan V. Zvyagin
Summary: This study identified expanded T cell clones in synovial fluid of spondyloarthritis (SpA) patients, which were shared between patients with similar HLA genotypes and persisted during recurrent synovitis. Several antigen-driven CD8+ clone groups associated with specific HLA alleles were discovered, indicating their relevance to SpA pathogenesis. These findings suggest a common immunopathological mechanism and the role of specific CD8+ T cell clones in SpA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Lauren K. Ridley, Mark C. Hwang, John D. Reveille, Lianne S. Gensler, Mariko L. Ishimori, Matthew A. Brown, Mohammad H. Rahbar, Amirali Tahanan, Michael M. Ward, Michael H. Weisman, Thomas J. Learch
Summary: This study investigated a subgroup of patients with ankylosing spondylitis (AS) who had long-standing disease and fused sacroiliac (SI) joints and found that females and males with early symptom onset had less radiographic damage in the SI joints. All 23 patients without syndesmophytes were HLA-B27 positive.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Immunology
Duygu Eryavuz Onmaz, Abdullah Sivrikaya, Kevser Isik, Sedat Abusoglu, Ilknur Albayrak Gezer, Fatma Humeyra Yerlikaya, Gulsum Abusoglu, Ali Unlu, Dilek Tezcan
Summary: The study found altered kynurenine pathway metabolism in AS patients. Conventional therapy and anti-TNF-alpha therapy are effective in reducing the Kynurenine/Tryptophan ratio and CRP levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Yimei Ding, Yue Yang, Luan Xue
Summary: This study utilized gene expression datasets and bioinformatics methods to identify the crucial role of neutrophils and T cells in the co-pathogenesis of ankylosing spondylitis (AS) and inflammatory bowel diseases (IBD). Diagnostic models based on these immune cells were established and validated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Yi-Ping Tang, Quan-Bo Zhang, Fei Dai, Xia Liao, Zeng-Rong Dong, Ting Yi, Yu-Feng Qing
Summary: Differentially expressed circRNAs were found in PBMCs of AS patients, which may be involved in the occurrence and development of AS. Among them, hsa_circRNA_012732 has the potential to be an indicator of disease activity, and hsa_circRNA_001544 has the potential to be a molecular marker for AS diagnosis.
CHINESE MEDICAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Yutong Jiang, Mingcan Yang, Yanli Zhang, Yefei Huang, Jialing Wu, Ya Xie, Qiujing Wei, Zetao Liao, Jieruo Gu
Summary: Anti-IL-17A therapy can effectively reverse immune cell imbalance in AS patients, specifically altering the distribution of T cell and B cell subsets.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Esen Yonca Bassoy, Michael Walch, Denis Martinvalet
Summary: The immune system protects the host by distinguishing self from non-self and relying on two lines of defense - the fast-acting innate immune system followed by the slower but potent adaptive immune system. T lymphocytes and B lymphocytes are essential for eliminating pathogens and establishing immunological memory.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zaied Ahmed Bhuyan, M. Arifur Rahman, Muralidhara Rao Maradana, Ahmed M. Mehdi, Anne-Sophie Bergot, Davide Simone, Marya El-Kurdi, Jose Garrido-Mesa, Cheng Bang Benjamin Cai, Amy J. Cameron, Aimee L. Hanson, Hendrik J. Nel, Tony Kenna, Paul Leo, Linda Rehaume, Matthew A. Brown, Francesco Ciccia, Ranjeny Thomas
Summary: Loss-of-function variants in RUNX3 are associated with ankylosing spondylitis (AS) and lead to immune dysregulation, intestinal dysbiosis, and inflammation. In AS, CD4-IEL cells and CD4+CD8+ T cells are decreased, while Treg cells are increased. TCR signaling dysfunction plays a role in the intestinal T-cell immunodeficiency observed in AS.
CLINICAL IMMUNOLOGY
(2023)
Article
Rheumatology
Rosalinde Stal, Sofia Ramiro, Desiree van der Heijde, Floris A. van Gaalen, Xenofon Baraliakos, Pedro M. Machado, Manouk de Hooge, Rosaline van den Berg, Monique Reijnierse, Juergen Braun, Robert Landewe, Alexandre Sepriano
Summary: In patients with radiographic axial spondyloarthritis, vertebral corner inflammation can lead to the development of syndesmophytes, but only a small portion of this effect is explained by vertebral corner fat deposition.
Article
Immunology
Zhengjuan Li, Xinyuan Liang, Xiaowen Chen, Yuying Chen, Fang Wang, Shuoshi Wang, Yihong Liao, Liping Li
Summary: This study investigated the role of thymus-derived Treg cells and peripherally derived Treg cells in maternal-fetal immune tolerance. It was found that the percentages of Treg cells in the blood and decidua increased during pregnancy, and these cells played an important immunosuppressive role. Thymus and spleen Treg cells showed stronger immune-suppression effects compared to in vitro induced Treg cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Ewa Kuca-Warnawin, Iwona Janicka, Krzysztof Bonek, Ewa Kontny
Summary: AS/ASCs and HD/ASCs exert similar immunomodulatory effects. Directly acting on CD4(+) T cells, ASCs can reduce the T-bet/GATA3 and RORc/FoxP3 ratios, decrease Treg formation, but increase IFN gamma and IL-17AF production.
Article
Rheumatology
Xinzhe Feng, Chen Wang, Boyao Ji, Junjie Qiao, Yihong Xu, Shanbang Zhu, Zhou Ji, Bole Zhou, Wenwen Tong, Weidong Xu
Summary: This study used single-cell RNA sequencing to reveal the dynamics of cell subpopulations, gene expression, and intercellular interactions during the pathogenesis of ankylosing spondylitis, providing new insights into the cellular and molecular mechanisms of osteogenesis and potential therapeutic strategies.
ANNALS OF THE RHEUMATIC DISEASES
(2023)