Inhibitor of Apoptosis Proteins as Novel Targets in Inflammatory Processes

XIAP Regulates Cytosol-Specific Innate Immunity to Listeria Infection

(2011) Laura D. Bauler et al.   PLoS Pathogens

IAP antagonists: promising candidates for cancer therapy

(2010) Raimund Mannhold et al.   DRUG DISCOVERY TODAY

Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

(2010) Federica Cossu et al.   PROTEIN SCIENCE

Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists

(2009) Chudi Ndubaku et al.   ACS Chemical Biology

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy

(2009) Pierfausto Seneci et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs

(2009) J Silke et al.   CELL DEATH AND DIFFERENTIATION

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

(2009) Mathieu J.M. Bertrand et al.   IMMUNITY

Increased expression of inhibitor of apoptosis proteins, survivin and XIAP, in non-small cell lung carcinoma

(2009) Krepela   INTERNATIONAL JOURNAL OF ONCOLOGY

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

(2009) James E. Vince et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of X-linked Inhibitor of Apoptosis Protein (XIAP) is an Independent Unfavorable Prognostic Factor in Childhood de Novo Acute Myeloid Leukemia

(2009) Ki Woong Sung et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

(2009) Ping-Hui Tseng et al.   NATURE IMMUNOLOGY

Dexamethasone-Induced Expression of Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Involves Activation of the Transcription Factors Activator Protein-1 and 3′,5′-Cyclic Adenosine 5′-Monophosphate Response Element-Binding Protein and the Generation of Reactive Oxygen Species

(2008) Robert Fürst et al.   ENDOCRINOLOGY

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Jun Controls Histone Modifications, NF- B Recruitment, and RNA Polymerase II Function To Activate the ccl2 Gene

(2008) S. Wolter et al.   MOLECULAR AND CELLULAR BIOLOGY

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA