Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 30, Issue 3, Pages 533-U357Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.109.200097
Keywords
CX3CR1; bone marrow; smooth muscle; differentiation
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Funding
- Health Research Board Ireland
- Science Foundation Ireland
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Objective-To determine whether CX(3)CR1(+) bone marrow cells have the capacity for smooth muscle cell (SMC) differentiation. Methods and Results-CX(3)CR1(+) and CX(3)CR1(-) cells were isolated from marrow of CX3CR1 transgenic mice and cultured in SMC differentiation media. Phenotypic and functional analyses showed only CX(3)CR1(+) bone marrow cells exhibit colony cell outgrowth with SMC-specific protein expression, calcium signaling, and contraction responses similar to mature SMC. Conclusion-CX(3)CR1 marks a bone marrow cells population that enriches for progenitors with capacity to differentiate in vitro into SMC-like cells. (Arterioscler Thromb Vasc Biol. 2010;30:533-535.)
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