Article
Biology
Flavia Hodel, Zhi Ming Xu, Christian Wandall Thorball, Roxane de la Harpe, Prunelle Letang-Mathieu, Nicole Brenner, Julia Butt, Noemi Bender, Tim Waterboer, Pedro Manuel Marques-Vidal, Peter Vollenweider, Julien Vaucher, Jacques Fellay
Summary: Coronary heart disease (CHD) is a major health problem, with complex interactions between genetic and environmental factors leading to its occurrence. A study using multiplex serological testing and genome-wide analysis on a population cohort revealed that high polygenic risk and infection with Fusobacterium nucleatum are independently associated with incident CHD.
Review
Medicine, General & Internal
Weize Xu, Lingyan Fang, Hemanyun Bai, Kangling Ke, Weiyan Li, Haitao Huang, Xiao Liang, Can Chen
Summary: This article provides an overview of the impact of psychological factors on coronary heart disease (CHD) and discusses the implications for psychological interventions. It examines the role of work stress, depression, anxiety, and social support in CHD, as well as the effects of psychological interventions. The article concludes with recommendations for future research and clinical practice.
Article
Genetics & Heredity
Liangping Zhao, Li Wang, Daimin Zhang, Yuqi Chen, Fulu Jin
Summary: The research showed that puerarin could alleviate coronary heart disease in rats by suppressing inflammation, improving cardiac function, and regulating the expression of key proteins and factors, including those affecting cholesterol and lipid levels.
Article
Multidisciplinary Sciences
Monireh-Sadat Mousavi, Sogol Meknatkhah, Alireza Imani, Parham Geramifar, Gholamhossein Riazi
Summary: This study aims to investigate the unique impacts of chronic physical and psychological stress on the cardiovascular system, revealing that psychological stress has a more significant impact on heart health compared to physical stress, including left ventricular hypertrophy, myocardial ischemia, and neuroinflammation. This highlights the importance of prioritizing psychological well-being during adolescence in preventing the occurrence of cardiovascular diseases in adulthood.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Analytical
Hao-Wen Li, Zhan Hu, Xiao Chen, Jie Ren, Hao Cui, Min Zhang, Liang Chen, Xin Hua, Jiangping Song, Yi-Tao Long
Summary: The study analyzed alterations in lipid metabolites in coronary artery tissues throughout the progression of atherosclerosis using ToF-SIMS mass spectrometry. Detailed descriptions of lipid features were obtained, a database of AS lipids was constructed, and the linoleic acid and arachidonic acid metabolic pathways were predicted to play critical roles in AS progression.
ANALYTICAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Yumei Wen, Haibin Zhang, Yu Tang, Rui Yan
Summary: The aim of this study is to explore the association between obstructive sleep apnea hypopnea syndrome (OSAHS) complicated with coronary heart disease (CHD) and inflammatory factors, glycolipid metabolism, obesity, and insulin resistance. The study found that patients in the OSAHS + CHD group had higher body weight, body mass index, waist circumference, and degree of sleepiness compared to the OSAHS group. In addition, they also had higher levels of inflammatory factors and blood lipids.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Jing Lin, Rongrong Yang, Yuan Zhang, Yabing Hou, Hongxi Yang, Xin Zhou, Tong Liu, Qing Yang, Yaogang Wang
Summary: This study investigated the association between depression and premature coronary heart disease (CHD). It found that depression was associated with an increased risk of premature CHD, and metabolic and inflammatory factors, particularly central obesity, may mediate this association.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Brandon Tejada, Roby Joehanes, Shih-Jen Hwang, Tianxiao Huan, Chen Yao, Jennifer E. Ho, Daniel Levy
Summary: The study found that higher inflammation scores were associated with smoking, older age, higher BMI, systolic blood pressure, lipids, and glucose levels, as well as greater odds of hypertension and diabetes. Additionally, higher baseline scores were linked to increased risk of new-onset cardiovascular disease events and all-cause mortality.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yeela Talmor-Barkan, Noam Bar, Aviv A. Shaul, Nir Shahaf, Anastasia Godneva, Yuval Bussi, Maya Lotan-Pompan, Adina Weinberger, Alon Shechter, Chava Chezar-Azerrad, Ziad Arow, Yoav Hammer, Kanta Chechi, Sofia K. Forslund, Sebastien Fromentin, Marc-Emmanuel Dumas, S. Dusko Ehrlich, Oluf Pedersen, Ran Kornowski, Eran Segal
Summary: Multi-omic profiling of patients with coronary artery disease reveals links between alterations in the serum metabolome with genetics, diet, and the microbiome. The study found that these metabolomic alterations are associated with metabolic impairment preceding clinically overt coronary artery disease. The results highlight the importance of understanding risk-factor heterogeneity in coronary artery disease through the serum metabolome.
Article
Endocrinology & Metabolism
Shuyao Su, Jingwen Fan, Yongli Yang, Chaojun Yang, Xiaocan Jia
Summary: This study explores the causal association between birth weight (BW) and coronary heart disease (CHD), analyzing the contributions of fetal and maternal factors and quantifying the mediating effects of cardiometabolic factors. The findings show that lower BW increases the risk of CHD, and both fetal-specific and maternal-specific BW contribute to this effect. Mediation analysis reveals the involvement of several cardiometabolic factors in the causal pathway from BW to CHD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Kari Peersen, John Munkhaugen, Elise Sverre, Oscar Kristiansen, Morten Fagerland, Nils Tore Vethe, Joep Perk, Einar Husebye, Toril Dammen
Summary: Patients with confirmed SAMS are more likely to have bilateral lower muscle symptoms compared to those with refuted SAMS. Psychological factors were not associated with self-perceived SAMS or confirmed SAMS.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Medicine, General & Internal
Amit Kaura, Adam Hartley, Vasileios Panoulas, Ben Glampson, Anoop S. V. Shah, Jim D. Davies, Abdulrahim R. Mulla, Kerrie Woods, Joe Omigie, Anoop Shah, Mark W. Thursz, Paul Elliott, Harry M. Hemmingway, Bryan Williams, Folkert Asselbergs, Michael O. O'Sullivan, Graham Lord, Adam P. Trickey, Jonathan A. C. Sterne, Dorian M. Haskard, Narbeh Melikian, Darrel Francis, Wolfgang S. Koenig, Ajay M. Shah, Rajesh Kharbanda, Divaka Perera, Riyaz Patel, Keith Channon, Jamil Mayet, Ramzi Khamis
Summary: This study aimed to investigate the prognostic value of mildly elevated hsCRP in patients with suspected ACS. The results showed a positive relationship between hsCRP levels and mortality, beyond the predictive value of troponin. This suggests the potential utility of hsCRP as a prognostic marker and in selecting patients for novel inflammation-targeting treatments.
Review
Cardiac & Cardiovascular Systems
Yan Zhou, Xueping Zhu, Hanming Cui, Jingjing Shi, Guozhen Yuan, Shuai Shi, Yuanhui Hu
Summary: The VEGF family, known for its role in regulating blood and lymphatic vessels, shows promise for treating coronary heart disease (CHD) by regulating various functions such as angiogenesis, apoptosis, inflammation, and fibrogenesis. Through binding with different receptors, VEGF proteins can modulate distinct physiological processes, offering potential pathways for treating CHD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jenifer M. Brown, Wunan Zhou, Brittany Weber, Sanjay Divakaran, Leanne Barrett, Courtney F. Bibbo, Jon Hainer, Viviany R. Taqueti, Sharmila Dorbala, Ron Blankstein, Marcelo F. Di Carli
Summary: Insufficient myocardial perfusion to match global metabolic demand may be a risk marker for heart failure.
EUROPEAN HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Afrose Liaquat, Ameerdad Khan, Saeed Ullah Shah, Hania Iqbal, Safa Iqbal, Atif Iqbal Rana, Habib Ur Rahman
Summary: This study investigates the use of coronary artery calcium scoring (CACS) as a tool for coronary artery disease (CAD) risk stratification and its association with conventional cardiovascular risk factors. The results demonstrate a strong positive correlation between CACS and coronary artery stenosis, indicating the potential of CACS as a useful tool for CAD risk assessment.
Article
Clinical Neurology
Tea Teras, Suvi Rovio, Jaana Pentti, Jenny Head, Mika Kivimaki, Sari Stenholm
Summary: Increasing and decreasing sleep difficulties may be associated with accelerated decline in cognitive function during retirement transition and post-retirement.
Editorial Material
Medicine, General & Internal
Severine Sabia, Archana Singh-Manoux
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Environmental Sciences
Erika Figueroa-Solis, David Gimeno Ruiz de Porras, Marianela Rojas-Garbanzo, Lawrence Whitehead, Kai Zhang, George L. Delclos
Summary: Cases of chronic kidney disease of unknown etiology (CKDu) are increasing in rural communities in Central America. This study aimed to estimate the prevalence and geographic distribution of self-reported work-related CKD and associated risk factors. The findings revealed that age, ethnicity, and high physical work demands were associated with work-related CKD. The highest prevalence of work-related CKD was found in western parts of Honduras and Nicaragua, overlapping with areas with high density of CKDu risk factors. Some areas with CKDu risk factor clusters had no reported work-related CKD, suggesting the need for monitoring new industries and sectors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Geriatrics & Gerontology
Benjamin Landre, Celine Ben Hassen, Mika Kivimaki, Mikaela Bloomberg, Aline Dugravot, Alexis Schniztler, Severine Sabia, Archana Singh-Manoux
Summary: This study examined changes in physical and mental functioning before the onset of frailty using repeat data spanning 25 years. The results showed that differences in trajectories of physical and mental functioning were observable 25 years before the onset of frailty. Furthermore, lower physical and mental functioning scores at age 50 were associated with an increased risk of developing frailty at older ages.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Mikaela Bloomberg, Aline Dugravot, Andrew Sommerlad, Mika Kivimaki, Archana Singh-Manoux, Severine Sabia
Summary: Education plays a crucial role in explaining sex differences in cognitive function, with middle-income countries showing larger disadvantages for females compared to the United States.
Letter
Cardiac & Cardiovascular Systems
Adam G. Tabak, Naveed Sattar, Mika Kivimaki
Article
Clinical Neurology
Melina Regy, Aline Dugravot, Severine Sabia, Elodie Bouaziz-Amar, Claire Paquet, Bernard Hanseeuw, Archana Singh-Manoux, Julien Dumurgier
Summary: This study found that ATN profiles are associated with mortality, with patients showing isolated evidence of neurodegeneration having a higher short-term mortality rate, and AD patients having the highest long-term mortality rate.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Genetics & Heredity
Aya Ayoub, Julie Lapointe, Hermann Nabi, Nora Pashayan
Summary: This study explored UK General Practitioners' knowledge of and attitudes towards risk-stratified screening, as well as their preferences for continuing professional development. The results showed that 49% of GPs were not familiar with the concept of PRS. While 75% agreed with earlier and more frequent screening for high-risk women, there was hesitation and disagreement towards a low-risk screening pathway. The top priority for future implementation was identified as training healthcare professionals, preferably through online formats.
Letter
Cardiac & Cardiovascular Systems
Pyry N. Sipila, Mika Kivimaki
Article
Nutrition & Dietetics
Sharon Parten Fowler, David Gimeno Ruiz de Porras, Michael D. Swartz, Paula Stigler Granados, Lynne Parsons Heilbrun, Raymond F. Palmer
Summary: Retrospective dietary recalls were conducted to investigate the association between maternal consumption of diet sodas/beverages (DSB) and aspartame during pregnancy/breastfeeding and the risk of autism spectrum disorder (ASD). The results showed that gestational/early-life exposure to diet soda or aspartame significantly increased the risk of autism in males, while no significant associations were found in females.
Article
Cell Biology
Andrew Sommerlad, Mika Kivimaki, Eric B. Larson, Susanne Roehr, Kokoro Shirai, Archana Singh-Manoux, Gill Livingston
Summary: The increasing number of people with dementia globally highlights the urgent need to reduce its scale and impact. Lifetime social participation may play a crucial role in reducing dementia risk and could have implications for individual behavior and public health policy. However, more research is needed to fully understand the causal relationship.
Review
Oncology
Sophie Audet, Catherine Doyle, Christopher Lemieux, Marc-Antoine Tardif, Andrea Gauvreau, David Simonyan, Hermann Nabi, Julie Lemieux
Summary: The study aimed to determine the proportion of trials reporting the number of patients assessed for eligibility before randomization. A total of 456 phase II, III, and IV RCTs published between 2013 and 2015 were reviewed. It was found that 236 trials (51.8%) reported the number of patients assessed for eligibility, and 184 trials (78%) provided reasons for patient exclusion. However, there is a need to improve the reporting of external validity parameters in medical oncology RCTs.
Review
Oncology
Cynthia Mbuya-Bienge, Nora Pashayan, Cornelia D. Kazemali, Julie Lapointe, Jacques Simard, Hermann Nabi
Summary: This systematic review examines breast cancer (BC) risk prediction tools incorporating a polygenic risk score (PRS) and explores factors that may impact their ability to predict a woman's risk of developing BC.
Article
Health Care Sciences & Services
Gary Ka-Ki Chung, Michael Marmot, Irene Yuk-Ying Ho, Siu-Ming Chan, Eric Tsz-Chun Lai, Samuel Yeung-Shan Wong, Eng-Kiong Yeoh, Jean Woo, Roger Yat-Nork Chung
Summary: This study assessed the gender-specific secular trends and area-level inequalities in life expectancy (LE) and disability-free life expectancy (DFLE) at age 65 in Hong Kong. The results showed that LE at age 65 increased by 3.7 years in men and 2.1 years in women between 2007 and 2020. However, DFLE increased at a slower rate, leading to a substantial increase in the proportion of life spent with disability. Furthermore, education was associated with both LE and DFLE, while female gender was more strongly associated with LE than with DFLE.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)