Article
Medicine, General & Internal
Giovanni E. Ferreira, Christina Abdel-Shaheed, Martin Underwood, Nanna B. Finnerup, Richard Day, Andrew McLachlan, Sam Eldabe, Joshua R. Zadro, Christopher G. Maher
Summary: This study provides a comprehensive overview of the efficacy, safety, and tolerability of antidepressants for different pain conditions. The results show that antidepressants are effective in some pain conditions, particularly proton pump inhibitors, postoperative pain, neuropathic pain, and fibromyalgia. However, there is insufficient evidence to support the efficacy of antidepressants in other pain conditions. A more nuanced approach is needed when prescribing antidepressants for pain conditions.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Food Science & Technology
Ilenia Corbelli, Angela Verzina, Ilaria Leone De Magistris, Gioacchino De Vanna, Paolo Eusebi, Giorgia Mataluni, Antonio Pisani, Addolorata Maria Pia Prudenzano, Maria Trojano, Marianna Delussi, Marina De Tommaso, Antonio Russo, Marcello Silvestro, Gioacchino Tedeschi, Paolo Calabresi, Paola Sarchielli
Summary: This multicentric prospective real-life study aimed to evaluate the efficacy and safety of long-term use with onabotulinumtoxinA in chronic migraine prophylaxis. The study found that chronic migraine patients treated with onaBT-A had significant improvement and good safety in both the first and second year of treatment.
Article
Neurosciences
Andrea Mendez Colmenares, Michelle W. Voss, Jason Fanning, Elizabeth A. Salerno, Neha P. Gothe, Michael L. Thomas, Edward McAuley, Arthur F. Kramer, Agnieszka Z. Burzynska
Summary: This study found that aerobic exercise training can improve white matter integrity in older adults, especially in late-myelinating regions. Additionally, the T1w/T2w signal may be a useful measure for studying white matter plasticity and deterioration in adults.
Review
Pharmacology & Pharmacy
Yao-Yao Chen, Xiao-Qian Ye, Tai-Chun Tang, Tian-Wei She, Min Chen, Hui Zheng
Summary: This study conducted an adjusted indirect comparison between CGRPmAbs and BoNT-A, finding similar effectiveness in the preventive treatment of chronic migraine. BoNT-A may be preferentially selected due to its cost-effectiveness. Further studies with direct comparison are needed to confirm these findings.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Khawar Ahmed, Hussain Rafiq, Shalmeen Tariq
Summary: The study demonstrated that topiramate has a good prophylactic effect and tolerability in patients with chronic migraines. Patients experienced a significant reduction in migraine intensity and frequency of episodes during treatment, along with a notable improvement in self-reported life impairment.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Clinical Neurology
Christian Lampl, Jan Versijpt, Faisal Mohammad Amin, Christina I. Deligianni, Raquel Gil-Gouveia, Tanvir Jassal, Antoinette MaassenVanDenBrink, Raffaele Ornello, Jakob Paungarttner, Margarita Sanchez-del-Rio, Uwe Reuter, Derya Uluduz, Tessa de Vries, Dena Zeraatkar, Simona Sacco
Summary: The objective of this paper is to critically re-evaluate the published trials on amitriptyline for migraine prophylaxis. Through a systematic review methodology, the authors searched various databases for randomized trials comparing amitriptyline with placebo for migraine prophylaxis. They assessed the outcomes of interest using established criteria and evaluated the risk of bias and certainty of evidence. The results indicated that amitriptyline may have a prophylactic role in reducing migraine days, but further research is needed.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Clinical Neurology
Saraswati Dhungana, Pawan Sharma, Sagun Ballav Pant, Pratikchya Tulachan, Manisha Chapagain, Saroj Prasad Ojha
Summary: The study compared the long-term efficacy of amitriptyline and divalproex in patients with episodic migraine, finding both drugs effective in improving headache frequency, duration, and severity without significant differences at different time points.
Article
Clinical Neurology
Yan Tereshko, Simone Dal Bello, Cherubino Di Lorenzo, Sara Pez, Alice Pittino, Roberto Sartor, Francesca Filippi, Christian Lettieri, Enrico Belgrado, Riccardo Garbo, Giovanni Merlino, Gian Luigi Gigli, Mariarosaria Valente
Summary: This retrospective single-center real-life study aimed to evaluate the efficacy of a 2:1 ketogenic diet and a Low-Glycemic-index Diet in chronic and high-frequency episodic migraine patients. The results showed that both diets were effective in reducing migraine symptoms and related disability.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Sport Sciences
J. A. K. O. B. R. ALLEN, R. E. M. Z. I. SATIROGLU, B. R. A. N. D. O. N. FICO, H. I. R. O. F. U. M. I. TANAKA, E. M. R. E. VARDARLI, J. E. F. F. R. E. Y. J. LUCI, E. D. W. A. R. D. F. COYLE
Summary: The study shows that 8 weeks of maximal power cycling training effectively increases muscle mass, maximal power, cardiovascular capacity, and functional tasks in untrained 50- to 68-year-olds.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Review
Clinical Neurology
Yohannes W. Woldeamanuel, Arao B. D. Oliveira
Summary: Strength training exercise regimens showed the highest efficacy in reducing migraine burden, followed by high-intensity aerobic exercise. The RoB2 assessment indicated that 85% of the included studies demonstrated low risk of bias.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Kobina K. Hagan, Wenyuan Li, Elizabeth Mostofsky, Suzanne M. Bertisch, Angeliki Vgontzas, Catherine Buettner, Murray A. Mittleman
Summary: Regular moderate to vigorous exercise at least three times per week is associated with fewer headache days per month in adults with episodic migraines, especially among those using prophylactic medications. However, exercise does not appear to affect headache intensity or duration.
Letter
Clinical Neurology
Junhee Han, Soo-Jin Cho
Summary: The study highlights inaccuracies in ranking using network meta-analysis, including inconsistencies in inclusion criteria, placebo usage, and potential bias risks. There are doubts about the effectiveness of using this statistical method to assess the effects of physical activities, as different migraine treatment methods may have synergistic effects.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Geriatrics & Gerontology
Jeremy Purcell, Robert Wiley, Junyeon Won, Daniel Callow, Lauren Weiss, Alfonso Alfini, Yi Wei, J. Carson Smith
Summary: Aging is associated with cognitive decline, but exercise can improve cognition in older adults by promoting neural differentiation.
NEUROBIOLOGY OF AGING
(2023)
Review
Geriatrics & Gerontology
Tsubasa Tomoto, Rong Zhang
Summary: Advanced age is a major risk factor for dementia, including Alzheimer's disease. Arterial aging is closely associated with cerebrovascular dysfunction and brain aging, while aerobic exercise can improve cerebral blood flow and cerebrovascular function, thereby maintaining brain health in older adults.
Article
Clinical Neurology
Alberto Raggi, Licia Grazzi, Erika Guastafierro, Alessia Marcassoli, Marco Passavanti, Danilo Antonio Montisano, Domenico D'Amico
Summary: This study compares the cost drivers between chronic migraine with medication overuse headache (CM-MOH) and episodic migraine, and evaluates the impact of improving migraine symptoms on disease cost. Significant reductions in headache frequency and its costs were observed, with the majority of cost reduction attributed to decreased indirect costs.
NEUROLOGICAL SCIENCES
(2022)
