Article
Biochemistry & Molecular Biology
Shuqin Yu, Shuo Wang, Lixin Xia, Huiwen Hu, Mingyu Zou, Zhiwen Jiang, Jinhua Chi, Yijie Zhang, Hongjian Li, Chaozhong Yang, Wanshun Liu, Baoqin Han
Summary: A study has successfully prepared a thiolated hyaluronic acid (SH-HA) hydrogel as a vitreous substitute, which demonstrated excellent biocompatibility and intraocular compatibility in experimental rabbits.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Jose Hurst, Annekatrin Rickmann, Nele Heider, Christine Hohenadl, Charlotte Reither, Andreas Schatz, Sven Schnichels, Kai Januschowski, Martin S. Spitzer
Summary: The study demonstrated that highly viscously thiol-modified cross-linked hyaluronate showed good biocompatibility in rabbit eyes, making it a promising potential as a vitreous substitute over 6 months.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Shuo Wang, Jinhua Chi, Zhiwen Jiang, Huiwen Hu, Chaozhong Yang, Wanshun Liu, Baoqin Han
Summary: The study developed a biocompatible, self-repairing, and in-situ injectable hydrogel using CMCTS and OHA as a vitreous substitute. The hydrogel showed good cytocompatibility on mouse fibroblast L929 and histocompatibility in New Zealand Rabbits, without significant and persistent adverse effects observed.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Indu Yadav, Shiv Dutt Purohit, Hemant Singh, Neeladri Singha Das, Chandrachur Ghosh, Partha Roy, Narayan Chandra Mishra
Summary: Developing an ideal vitreous substitute/implant is a challenge, as there is a high risk of bacterial infection associated with implants. In this study, a bacterial resistant vitreous implant was developed by incorporating the antibiotic meropenem into a hydrogel. The hydrogel showed desired biocompatibility, transparency, water content, and viscoelasticity, making it suitable for vitreous substitute.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mengying Zhang, Huimin Yu, Jinglu Hu, Zhengyu Zhao, Lei Liu, Gaomin Yang, Tingli Wang, Guang Han, Shiyong Song
Summary: This study prepared a nanocarrier based on hyaluronic acid and solanesol, which showed great potential in cancer therapy. Loading doxorubicin into the nanocarrier enabled pH-sensitive drug release, with lower cardiotoxicity and hepatotoxicity compared to free doxorubicin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Hesuyuan Huang, Xuyang Ding, Dan Xing, Jianjing Lin, Zhongtang Li, Jianhao Lin
Summary: In this study, a series of glycosides of oligosaccharides of hyaluronic acid (o-HAs) were synthesized and their effects on osteoarthritis (OA) progression were examined. The results showed that o-HA derivatives had similar therapeutic mechanisms to high molecular weight hyaluronic acid in alleviating OA. This study supports the potential of oligosaccharide-mediated therapy for OA.
Article
Pharmacology & Pharmacy
Alexis Laurent, Alexandre Porcello, Paula Gonzalez Fernandez, Annick Jeannerat, Cedric Peneveyre, Philippe Abdel-Sayed, Corinne Scaletta, Nathalie Hirt-Burri, Murielle Michetti, Anthony de Buys Roessingh, Wassim Raffoul, Eric Allemann, Olivier Jordan, Lee Ann Applegate
Summary: This study experimentally characterized formulations containing progenitor tenocyte-derived APIs and hyaluronan, confirming their potential applications in treating tendon disorders with advantages in physical and chemical stability, antioxidant properties, and injectability.
Review
Engineering, Biomedical
Niranjan G. Kotla, Isma Liza Mohd Isa, Aitor Larranaga, Balaji Maddiboyina, Samantha K. Swamy, Gandhi Sivaraman, Praveen K. Vemula
Summary: In recent years, there has been a significant expansion in the research and clinical applications of hyaluronic acid-based scaffolds, medical devices, and bioconjugate systems. These developments are driven by the abundance of hyaluronic acid in mammalian tissues and its potential for chemical modifications. This review summarizes the importance of chemical modifications of hyaluronic acid, various advancements in bioconjugate derivatives, and their potential advantages in terms of physicochemical and pharmacological properties.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Applied
Kristyna Skuhrovcova, Adela Kotzianova, Lenka Bardonova, Ondrej Zidek, Evgeniy Toropitsyn, Hana Vagnerova, Aneta Capova, Katerina Dostalova, Martina Hermannova, Marek Pokorny, Vladimir Velebny
Summary: This paper focuses on the preparation of nanofibrous layers produced from hydrophobized derivatives of hyaluronan for potential uses in regenerative medicine. The structural modification expands the material's range of potential applications, making it breathable, mechanically stable, and non-toxic to cells. The self-supporting nanofibrous matrix can be used as a scaffold or porous wound dressing.
CARBOHYDRATE POLYMERS
(2022)
Review
Oncology
Chengcheng Liao, Qian Wang, Jiaxing An, Jie Chen, Xiaolan Li, Qian Long, Linlin Xiao, Xiaoyan Guan, Jianguo Liu
Summary: The interaction of CD44, a non-kinase transmembrane glycoprotein, with ligands like hyaluronic acid plays a crucial role in tumor occurrence and development. Changes in CD44 glycosylation can regulate multiple signaling pathways, impacting the tumor microenvironment and cell fate. However, our current understanding of CD44 glycosylation and its effects on tumors is limited.
FRONTIERS IN ONCOLOGY
(2022)
Review
Anatomy & Morphology
Qiwei Dong, Dingkun Wu, Moqiu Li, Wei Dong
Summary: Artificial cornea implants have become the gold standard for treating damaged corneas, but face challenges such as donor shortage and graft failure; polysaccharides such as cellulose, chitosan are widely used in the production of tissue-engineered corneas, and have excellent biocompatibility and processability.
Review
Chemistry, Applied
Xueli Zheng, Botao Wang, Xin Tang, Bingyong Mao, Qiuxiang Zhang, Tianmeng Zhang, Jianxin Zhao, Shumao Cui, Wei Chen
Summary: Hyaluronic acid (HA) is crucial for maintaining the stability of tissue's internal environment. Its decreasing levels with age lead to age-related health problems, which can be prevented or treated by exogenous HA supplements. Probiotics, on the other hand, have the potential to promote endogenous HA synthesis and alleviate symptoms caused by HA loss.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Organic
Patricia Guettlein, Hedda Schrey, Haoxuan Zeng, Rainer Schobert
Summary: 2-Caffeoyl-3-ketohexulofuranosonic acid gamma-lactone and its derivatives were synthesized and screened for antibiotic activities and effects on microbial biofilms.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Gozde Yurdabak Karaca, Y. Emre Bulbul, Aysegul Uygun Oksuz
Summary: Micro/nanomotors have shown great potential in drug delivery and controlled release, especially in the fields of cancer treatment and lab-on-a-chip devices. Hyaluronic acid is a commonly used material for drug delivery due to its biocompatibility and non-immunogenicity. Cold atmospheric plasma is an emerging technology that can enhance drug release and bioavailability. This study successfully synthesized gold-hyaluronic acid micromotors and investigated their application in drug release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Instruments & Instrumentation
Sabina Di Matteo, Chiara Di Meo, Guido Carpino, Nicole Zoratto, Vincenzo Cardinale, Lorenzo Nevi, Diletta Overi, Daniele Costantini, Claudio Pinto, Elita Montanari, Marco Marzioni, Luca Maroni, Antonio Benedetti, Marco Viola, Tommasina Coviello, Pietro Matricardi, Eugenio Gaudio, Domenico Alvaro
Summary: The intrahepatic biliary epithelium plays a significant role in excreting bicarbonate in bile. Recent studies have shown that budesonide enhances the efficacy of ursodeoxycholic acid in primary biliary cholangitis patients. This study investigates the effects of dexamethasone-loaded nanohydrogels (NHs) on transport processes in the biliary epithelium and liver injury induced by experimental cholestasis. The results suggest that NHs/dex formulation could be a promising candidate for further investigation in preclinical models of cholangiopathies.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Engineering, Chemical
V. M. Costa, M. C. M. de Souza, P. B. A. Fechine, A. C. Macedo, L. R. B. Goncalves
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
(2016)
Article
Engineering, Chemical
Nathalia Saraiva Rios, Maisa Pessoa Pinheiro, Magno Luis Bezerra Lima, Denise Maria Guimaraes Freire, Ivanildo Jose da Silva Junior, Enrique Rodriguez-Castellon, Hosiberto Batista de Sant'Ana, Andre Casimiro Macedo, Luciana Rocha Barros Goncalves
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2018)
Article
Agricultural Engineering
Aline M. B. Pires, Andre C. Macedo, Silvia Y. Eguchi, Maria H. A. Santana
BIORESOURCE TECHNOLOGY
(2010)
Article
Microbiology
Adriano H. Oliveira, Cristiane C. Ogrodowski, Andre C. de Macedo, Maria Helena A. Santana, Luciana R. B. Goncalves
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2013)
Article
Biotechnology & Applied Microbiology
Andre Casimiro de Macedo, Maria Helena Andrade Santana
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2012)
Article
Engineering, Environmental
Natan Camara Gomes e Silva, Andre Casimiro de Macedon, Alvaro Daniel Teles Pinheiro, Maria Valderez Ponte Rocha
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2019)
