Article
Pathology
Diane Donegan, Alicia Algeciras-Schimnich, Susan Ashrafzadeh-Kian, Dana Erickson
Summary: This study found that using IGF-1 concentrations at 6 weeks postoperatively can effectively predict surgical outcomes in acromegaly patients, with most patients able to assess clinical outcomes through this method.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Endocrinology & Metabolism
Claudia Campana, Francesco Cocchiara, Giuliana Corica, Federica Nista, Marica Arvigo, Jessica Amaru, Diego Criminelli Rossi, Gianluigi Zona, Diego Ferone, Federico Gatto
Summary: Discordance between GH and IGF-1 levels in acromegaly patients is influenced by GH cutoff values. The use of GH(m) can mitigate the impact of GH cutoffs and improve predictive accuracy. Fasting GH levels (both GH(f) and GH(m)) are poor predictors of IGF-1 normalization in this cohort.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Clinical Neurology
Andrew Iskander, Trevor Jairam, Christine Wang, Brian J. Murray, Mark I. Boulos
Summary: Sleep latency is the time it takes to enter sleep, and shorter sleep latencies may indicate excessive daytime sleepiness and pathological sleep conditions. This study reviewed normative values of mean sleep latency from 110 healthy adult cohorts and analyzed the impact of demographic and methodological variables. The results suggest that there were no significant associations between mean sleep latency and these variables, but a negative association was found between mean sleep latency and apnea-hypopnea index on prior night polysomnography.
Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Article
Biotechnology & Applied Microbiology
Zequn Lu, Ning Liu, Huoqing Huang, Yuan Wang, Tao Tu, Xing Qin, Xiaolu Wang, Jie Zhang, Xiaoyun Su, Jian Tian, Yingguo Bai, Huiying Luo, Bin Yao, Honglian Zhang
Summary: Human insulin-like growth factor-1 (IGF-1) and its analog Long R3 IGF-1 (LR3 IGF-1) were successfully recombinantly expressed and produced in the Pichia pastoris expression system by fusion with highly expressed xylanase XynCDBFV. The purified IGF-1 and LR3 IGF-1 displayed excellent bioactivity of cell proliferation compared to the standard IGF-1. Furthermore, high heterologous expression levels of the fusion proteins were achieved by fermentation in a 15-L bioreactor, which could be used for both clinical and scientific applications.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Zahra Soleimani, Rosa Haghshenas, Yousef Farzi, Masud Yunesian, Amirmohammad Khalaji, Amir Hossein Behnoush, Amir Karami, Mahia Mehrabi, Erfan Ghasemi, Fatemeh Ashkani, Kazem Naddafi, Abolghasem Djazayeri, Hamed Pouraram, Alireza Mesdaghinia, Farshad Farzadfar
Summary: This study investigated the exposure of Iranian adults to polyaromatic hydrocarbons (PAHs) and found high concentrations of 1-hydroxypyrene metabolites in urine samples. The urinary concentrations of 1-hydroxypyrene metabolites were positively associated with body composition, BMI, and age, with BMI showing a significant relationship.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Zahra Soleimani, Rosa Haghshenas, Yousef Farzi, Masud Yunesian, Amirmohammad Khalaji, Amir Hossein Behnoush, Amir Karami, Mahia Mehrabi, Erfan Ghasemi, Fatemeh Ashkani, Kazem Naddafi, Abolghasem Djazayeri, Hamed Pouraram, Alireza Mesdaghinia, Farshad Farzadfar
Summary: This study investigated the exposure to 1-hydroxypyrene in healthy Iranian adults and found higher concentrations compared to similar studies in other countries. These results provide valuable information for the interpretation of biomonitoring results in Iran.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Laura Di Patria, Giosue Annibalini, Amelia Morrone, Lorenzo Ferri, Roberta Saltarelli, Luca Galluzzi, Aurora Diotallevi, Matteo Bocconcelli, Maria Alice Donati, Rita Barone, Renzo Guerrini, Jaak Jaeken, Vilberto Stocchi, Elena Barbieri
Summary: This study reveals the direct link between N-glycosylation defects found in Congenital Disorders of Glycosylation (CDG) and the impairment of IGF-1/IGF-1R signaling components. The study indicates that deficiencies in N-glycosylation affect IGF-1 secretion and IGF-1R expression, leading to reduced IGF-1 availability and local activity in CDG patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Endocrinology & Metabolism
Mirjana Macvanin, Zoran Gluvic, Jelena Radovanovic, Magbubah Essack, Xin Gao, Esma R. Isenovic
Summary: Cardiovascular disorders are increasingly common and pose a significant global health issue. Recent research emphasizes the importance of insulin-like growth factor 1 (IGF-1) in maintaining cardiovascular health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Virology
Agata Jozefiak, Magdalena Larska, Malgorzata Pomorska-Mol, Jakub J. Ruszkowski
Summary: IGF-1 activates intracellular signaling pathways by binding to IGF-1R, including PI3K/AKT and MAPK pathways, to regulate cell proliferation and apoptosis. The IGF-1 signaling also promotes cell differentiation and proliferation through the Ras/MAPK pathway.
Article
Agriculture, Dairy & Animal Science
J. Nagasao, H. Fukasawa, K. Yoshioka, N. Fujimura, M. Kobayashi, Y. Tsunemi, A. Nomoto, S. Mitsui, H. Murata, I Yokoyama, Y. Komiya, K. Arihara
Summary: This study investigated the expression of insulin-like growth factor 1 (IGF-1) and IGF-1 type 1 receptor (IGF-1R) in skeletal muscle fiber types in chickens with hepatic fibrosis induced by bile duct ligation (BDL). The results showed that hepatic fibrosis caused a significant decrease in the cross-sectional area (CSA) of myofibers in the pectoralis muscles, while the CSA in the femorotibialis lateralis muscle did not decrease. Furthermore, type I fibers expressed both IGF-1 and IGF-1R and exhibited hypertrophy.
Article
Nutrition & Dietetics
Janna Enderle, Dejan Reljic, Bjorn Jensen, Sven Peine, Yurdaguel Zopf, Anja Bosy-Westphal
Summary: In this study, continuous reference ranges for body composition parameters were derived using multiple regression analysis. The results showed that age had a minor impact on FMI, VAT, and ALSTI, while BMI substantially increased the explained variance for these parameters. On the other hand, age was a major determinant of the explained variance for SMI, with BMI also contributing. These findings are important for body composition evaluation in overweight and older individuals.
CLINICAL NUTRITION
(2023)
Review
Endocrinology & Metabolism
Manuel H. Aguiar-Oliveira, Roberto Salvatori
Summary: The study of isolated GH deficiency caused by a homozygous inactivating mutation in the GH releasing hormone receptor gene has shown a variety of phenotypic changes in body size and function, with a greater number of beneficial consequences.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Review
Oncology
Guoqiang Liu, Minggang Zhu, Mingrui Zhang, Feng Pan
Summary: Prostate cancer (PCa) is a highly heterogeneous disease driven by gene alterations and microenvironmental influences. IGF-1 and its receptor IGF-1R have emerged as vital drivers in the development of PCa. Inhibitory reagents targeting IGF-1/IGF-1R signaling have shown promise in limiting cancer development, but further research and clinical trials are needed.
Article
Cell Biology
Tri Wahyuni, Arisa Kobayashi, Shota Tanaka, Yoshiaki Miyake, Ayaha Yamamoto, Anton Bahtiar, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Kotaro Matsumoto, Makiko Maeda, Masanori Obana, Yasushi Fujio
Summary: MaR1 induces cardiomyocyte hypertrophy through the RORa/IGF-1/PI3K/Akt pathway, which may play a key role in orchestrating the resolution of inflammation with myocardial repair.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
