Association between Birth Weight and Cardiovascular Risk Factors in Adolescents

Background: Birth weight (BW) is a medium-and long-term risk determinant of cardiovascular risk factors. Objective: To assess the association between BW and cardiovascular risk factors in adolescents of the city of Salvador, Bahia state. Methods: Cross-sectional study with comparison of BW groups. Sample comprising 250 adolescents classified according to the BMI as follows: high-normal (>= 50th percentile and < 85th percentile); overweight (>= 85th percentile and < 95th percentile); and obesity (>= 95th percentile). The risk variables compared were as follows: waist circumference (WC); arterial blood pressure; lipid profile; glycemia; serum insulin; HOMA-IR; and metabolic syndrome. The BW was informed by parents and classified as follows: low (BW <= 2,500g); normal (BW > 2,500g and < 4,000g); and high (BW >= 4,000g). Results: One hundred and fifty-three (61.2%) girls, age 13.74 +/- 2.03 years, normal BW 80.8%, low BW 8.0%, and high BW 11.2%. The high BW group as compared with the normal BW group showed a higher frequency of obesity (42.9%, p=0.005), elevated SBP and DBP (42.9%, p=0.000 and 35.7%, p=0.007, respectively), and metabolic syndrome (46.4%, p=0.002). High BW adolescents as compared with normal BW adolescents had a prevalence ratio for high SBP 3.3 (95% CI: 1.7-6.4) and obesity 2.6 (95% CI: 1.3-5.2). The WC of high BW adolescents was 83.3 +/- 10.1 (p=0.038). The lipid profile showed no statistically significant differences. Conclusion: Our findings suggest that obesity, elevated SBP and DBP, and metabolic syndrome during adolescence might be associated with high BW.