Article
Cardiac & Cardiovascular Systems
Laneshia K. Tague, Bahaa Bedair, Chad Witt, Derek E. Byers, Rodrigo Vazquez-Guillamet, Hrishikesh Kulkarni, Jennifer Alexander-Brett, Ruben Nava, Varun Puri, Daniel Kreisel, Elbert P. Trulock, Andrew Gelman, Ramsey R. Hachem
Summary: This study found that donor-based lung protective ventilation (dLPV) can reduce the risk of adverse outcomes such as PGD and improve 1-year survival. The predicted total lung capacity (pTLC) ratio between donor and recipient is associated with the risk of PGD, but this association is attenuated by the use of dLPV.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jesse M. Rappaport, Hafiz Umair Siddiqui, Lucy Thuita, Marie Budev, Kenneth R. McCurry, Eugene H. Blackstone, Usman Ahmad
Summary: The objective of this study was to investigate the effects of donor smoking and substance use on primary graft dysfunction, allograft function, and survival after lung transplant. The results showed that donor smoking was associated with decreased forced expiratory volume in 1 second after transplantation, while substance use did not affect allograft function. Therefore, donor smoking or substance use alone should not be a contraindication for lung donation or transplant.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Multidisciplinary Sciences
J. M. Duenas-Jurado, P. A. Gutierrez, A. Casado-Adam, F. Santos-Luna, A. Salvatierra-Velazquez, S. Carcel, C. J. C. Robles-Arista, C. Hervas-Martinez
Summary: The study analyzed 404 lung transplants conducted over 23 years in a Spanish hospital and developed a powerful model for donor-recipient matching. Variables predicting increased survival included vital capacity, carbon dioxide pressure, donor ventilation, and ischemia time. The combination of statistical methods and machine learning can enhance decision-making on donor-recipient compatibility and improve transplant outcomes.
Article
Cardiac & Cardiovascular Systems
Keiji Yamanashi, Akihiro Ohsumi, Hiromi Oda, Satona Tanaka, Yoshito Yamada, Daisuke Nakajima, Hiroshi Date
Summary: The objective of this study was to investigate the depletion of mononuclear phagocytes and the attenuation of ischemia-reperfusion injury by clodronate-liposome during ex vivo lung perfusion. The experiments determined the number of mononuclear phagocytes in flushed grafts using flow cytometry and administered clodronate-liposome into the perfusate during ex vivo lung perfusion. The results showed a significant reduction in the number of mononuclear phagocytes in the clodronate group, improved lung function, and reduced lung injury.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Surgery
Yasuhiro Shudo, Aiman Alassar, Hanjay Wang, Bharathi Lingala, Hao He, Yuanjia Zhu, William Hiesinger, John W. MacArthur, Jack H. Boyd, Anson M. Lee, Maria Currie, Y. Joseph Woo
Summary: This study aimed to evaluate the outcomes of adult orthotopic heart transplant recipients who underwent veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for severe primary graft dysfunction (PGD). The results showed that the VA-ECMO cohort had lower survival rates but potential benefits in treating severe PGD and supporting marginal donor hearts.
TRANSPLANT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
John J. Squiers, J. Michael DiMaio, Johanna Van Zyl, Brian Lima, Gonzalo Gonzalez-Stawisnksi, Aldo E. Rafael, Dan M. Meyer, Shelley A. Hall
Summary: This retrospective study analyzed data from consecutive cardiac transplant patients at a single center between 2012 and 2015, finding that patients with moderate to severe PGD had increased mortality risk up to 5 years post-transplant. However, patients with moderate to severe PGD who survived the first 90 days post-transplant no longer had a higher risk of mortality compared to those with mild or no PGD.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Respiratory System
Takahide Toyoda, Emily Jeong Cerier, Adwaiy Jayant Manerikar, Viswajit Kandula, Ankit Bharat, Chitaru Kurihara
Summary: A retrospective study analyzed surgical variables of lung transplant patients and identified risk factors associated with primary graft dysfunction (PGD). The results showed that longer operative time and intraoperative veno-arterial extracorporeal membrane oxygenation (VA-ECMO) use were associated with the occurrence of PGD, and higher grades of PGD were associated with lower 1-year survival rate. These findings are important for predicting and intervening in the occurrence of PGD.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Cell Biology
Aadil Ali, Aizhou Wang, Rafaela V. P. Ribeiro, Erika L. Beroncal, Cristina Baciu, Marcos Galasso, Bruno Gomes, Andrea Mariscal, Olivia Hough, Edson Brambate, Etienne Abdelnour-Berchtold, Vinicius Michaelsen, Yu Zhang, Anajara Gazzalle, Eddy Fan, Laurent Brochard, Jonathan Yeung, Tom Waddell, Mingyao Liu, Ana C. Andreazza, Shaf Keshavjee, Marcelo Cypel
Summary: Cold static preservation at 10 degrees Celsius can lead to better preservation of donor lungs with improved mitochondrial health and metabolic protection. This approach has been successfully applied in clinical settings, allowing for extended preservation time and improved outcomes for lung transplant recipients. Preserving lungs at 10 degrees Celsius may become the new standard of care for prolonged pulmonary preservation.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Maximilian J. Roesel, Nirmal S. Sharma, Andreas Schroeter, Tomohisa Matsunaga, Yao Xiao, Hao Zhou, Stefan G. Tullius
Summary: Transplant centers use older donors to meet the demand for lung transplantation, but this is associated with a higher rate of lung ischemia reperfusion injury. Understanding and improving the condition of older lungs is critical to optimize transplant outcomes. Ex vivo lung perfusion can recondition ischemic lungs through ex-vivo perfusing and ventilation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
David Li, Justin Weinkauf, Ali Kapasi, Alim Hirji, Rhea Varughese, Dale Lien, Jayan Nagendran, Kieran Halloran
Summary: Severe PGD is significantly associated with the frequency and severity of BLAD following lung transplantation, but not with CLAD. This highlights the impact of PGD severity on graft function, while showing no correlation with the frequency and onset of chronic lung allograft dysfunction.
RESPIRATORY MEDICINE
(2021)
Article
Surgery
Yoann Elmaleh, Christian De Tymowski, Nathalie Zappella, Sylvain Jean-Baptiste, Alexy Tran-Dinh, Sebastien Tanaka, Sonia Yung, Brice Lortat-Jacob, Herve Mal, Yves Castier, Enora Atchade, Philippe Montravers
Summary: The study found that pre-donation blood transfusion of the donor is associated with the occurrence of stage 3 PGD after LT, while pre-donation transfusion does not significantly affect the mortality rate of LT recipients.
CLINICAL TRANSPLANTATION
(2021)
Article
Respiratory System
Francois Parquin, Benjamin Zuber, Alexandre Vallee, Jean-Luc Taupin, Elise Cuquemelle, Stephanie Malard, Mathilde Neuville, Jerome Devaquet, Morgan Le Guen, Julien Fessler, Laurence Beaumont, Clement Picard, Abdulmonem Hamid, Sylvie Colin de Verdiere, Dominique Grenet, Sandra De Miranda, Matthieu Glorion, Edouard Sage, Ciprian Pricopi, Julien De Wolf, Anne-Laure Brun, Elisabeth Longchampt, Charles Cerf, Antoine Roux, Olivier Brugiere
Summary: The study compared outcomes of desensitised LTx patients with high DSAs and those with low or no DSAs. It found that the desensitisation protocol reduced the level of immunodominant DSAs and cleared high DSAs were identified as an independent predictor of graft survival.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Khalil Aburahma, Jawad Salman, Bastian Engel, Florian W. R. Vondran, Mark Greer, Dietmar Boethig, Thierry Siemeni, Murat Avsar, Nicolaus Schwerk, Carsten Mueller, Richard Taubert, Marius M. Hoeper, Tobias Welte, Hans H. Wedemeyer, Nicolas Richter, Gregor Warnecke, Igor Tudorache, Axel Haverich, Christian Kuehn, Gerrit Grannas, Fabio Ius
Summary: A combined lung and liver transplant in patients with cystic fibrosis did not impair lung graft function, and the liver graft showed tolerogenic effects against rejection.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Review
Gastroenterology & Hepatology
Mamatha Bhat, Madhumitha Rabindranath, Beatriz Sordi Chara, Douglas A. Simonetto
Summary: Liver transplantation (LT) is a life-saving treatment for end-stage liver disease, and artificial intelligence (AI) offers a data-driven approach to improve clinical decision-making in LT. AI can be applied in optimizing transplant candidacy decision-making, donor-recipient matching, and guiding the management of LT recipients. However, limitations such as dataset imbalances, data privacy issues, and a lack of research practices to benchmark model performance in the real world need to be addressed. Overall, AI has the potential to enhance personalized clinical decision-making in liver transplant medicine.
JOURNAL OF HEPATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rasmus Rivinius, Carolin Gralla, Matthias Helmschrott, Fabrice F. Darche, Philipp Ehlermann, Tom Bruckner, Wiebke Sommer, Gregor Warnecke, Stefan Kopf, Julia Szendroedi, Norbert Frey, Lars P. Kihm
Summary: The presence of pre-transplant type 2 diabetes mellitus (T2DM) in cardiac transplant recipients is associated with increased graft failure and 5-year mortality after transplantation. Well-controlled T2DM is clinically relevant for improving the survival rate of heart transplant recipients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)