Foot-and-mouth disease virus low-fidelity polymerase mutants are attenuated

An increased replication fidelity mutant of foot-and-mouth disease virus retains fitness in vitro and virulence in vivo

(2013) Jianxiong Zeng et al.   ANTIVIRAL RESEARCH

Vaccine-derived Mutation in Motif D of Poliovirus RNA-dependent RNA Polymerase Lowers Nucleotide Incorporation Fidelity

(2013) Xinran Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Polymerase Mechanism-based Strategy for Viral Attenuation and Vaccine Development

(2012) Spencer A. Weeks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coxsackievirus B3 mutator strains are attenuated in vivo

(2012) N. F. Gnadig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inoculation of newborn mice with non-coding regions of foot-and-mouth disease virus RNA can induce a rapid, solid and wide-range protection against viral infection

(2011) Miguel Rodríguez-Pulido et al.   ANTIVIRAL RESEARCH

Arbovirus high fidelity variant loses fitness in mosquitoes and mice

(2011) L. L. Coffey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competitive Fitness of Oseltamivir-Sensitive and -Resistant Highly Pathogenic H5N1 Influenza Viruses in a Ferret Model

(2010) E. A. Govorkova et al.   JOURNAL OF VIROLOGY

Host Alternation of Chikungunya Virus Increases Fitness while Restricting Population Diversity and Adaptability to Novel Selective Pressures

(2010) L. L. Coffey et al.   JOURNAL OF VIROLOGY

Identification of a conformational epitope on the VP1 G-H Loop of type Asia1 foot-and-mouth disease virus defined by a protective monoclonal antibody

(2010) Haiwei Wang et al.   VETERINARY MICROBIOLOGY

Quasispecies Theory and the Behavior of RNA Viruses

(2010) Adam S. Lauring et al.   PLoS Pathogens

Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

(2010) Laura I. Levi et al.   PLoS Pathogens

The 30th anniversary of quasispecies. Meeting on ‘Quasispecies: past, present and future’

(2009) Esteban Domingo et al.   EMBO REPORTS

Validation of two real-time RT-PCR methods for foot-and-mouth disease diagnosis: RNA-extraction, matrix effect, uncertainty of measurement and precision

(2009) Nesya Goris et al.   JOURNAL OF VIROLOGICAL METHODS

Differences in the virulence of two strains of Foot-and-Mouth Disease Virus Serotype A with the same spatiotemporal distribution

(2009) Soledad García-Nuñez et al.   VIRUS RESEARCH

Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context

(2008) M. Gutierrez-Rivas et al.   JOURNAL OF GENERAL VIROLOGY

Engineering attenuated virus vaccines by controlling replication fidelity

(2008) Marco Vignuzzi et al.   NATURE MEDICINE

No evidence of selection for mutational robustness during lethal mutagenesis of lymphocytic choriomeningitis virus

(2008) Verónica Martín et al.   VIROLOGY