Review
Biochemistry & Molecular Biology
Yang Yang, Panpan Huang, Yutong Ma, Ruoxuan Jiang, Cong Jiang, Guanghui Wang
Summary: This review focuses on signal sensing and transduction in Fusarium species, highlighting the role of G protein-coupled receptors and MAP kinase pathways. These signaling pathways play important roles in the growth, development, and pathogenicity of Fusarium fungi, and they are involved in coordinating fungal developments and infection-related morphogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Microbiology
Zhenhe Su, Xiaomeng Liu, Qinggang Guo, Lifeng Xuan, Xiuyun Lu, Lihong Dong, Xiaoyun Zhang, Peipei Wang, Weisong Zhao, Yuanhang Qu, Shezeng Li, Ping Ma
Summary: In this study, the pathogenicity of two pectinolytic strains of Pectobacterium spp. (P. brasiliense and P. carotovorum) was investigated. The results showed that P. carotovorum had higher cell wall-degrading enzyme activities and caused more severe disease symptoms in potato tubers compared to P. brasiliense. The pathogenicity of both strains increased with temperature. Furthermore, coinoculation of P. carotovorum with P. brasiliense resulted in more severe pathogenicity, especially when P. carotovorum had a bacterial number advantage at the beginning. These findings provide new insights into the pathogenicity caused by mixed infections of different Pectobacterium spp.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Immunology
Jianfei Liu, Kewei Qin, Chenglin Wu, Kaifei Fu, Xiaojie Yu, Lijun Zhou
Summary: The study found that the increased pathogenicity of environmental Vibrio parahaemolyticus is associated with genomic changes, where differences in pathogenicity among different strains are mainly due to variances in the distribution of key genetic elements and secretory system compositions. The hypothesis of unique pathogenic effects based on genomic analysis was validated by the survival rate of mouse models infected with different strains, and antibiotic resistance results demonstrated the multi-directional evolutionary potential in environmental Vibrio parahaemolyticus.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Meng Wang, Yu Fan, Ping Liu, Yehua Liu, Jianlei Zhang, Yan Jiang, Chunlei Zhou, Lei Yang, Ce Wang, Chengqian Qian, Chao Yuan, Si Zhang, Xiaohang Zhang, Zhiqiu Yin, Hong Mu, Yuhui Du
Summary: Raoultella ornithinolytica is a poorly understood opportunistic pathogen with multidrug resistance mechanisms. The isolate WM1 exhibited resistance to multiple antimicrobials and carried two plasmids with multidrug resistance regions. In addition to virulence-related elements, the strain showed genetic diversity, emphasizing the importance of infection control and antimicrobial stewardship.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Environmental Sciences
Wensi Wu, Lingmin Zhao, Lixing Huang, Yingxue Qin, Jiaonan Zhang, Jiaolin Zhang, Qingpi Yan
Summary: The fliS gene of P. plecoglossicida plays an important role in regulating motility, chemotaxis, adhesion, biofilm formation, and the immune response of Epinephelus coioides to infection.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Panpan Zhu, Min Kou, Changying Liu, Shuai Zhang, Ruihua Lu, Zhongqiang Xia, Maode Yu, Aichun Zhao
Summary: Genome sequencing and analysis of Ciboria shiraiana revealed insights into its pathogenic mechanisms, evolutionary patterns, and gene expression profiles, providing new research directions for the prevention and control of this pathogen.
MOLECULAR PLANT-MICROBE INTERACTIONS
(2021)
Article
Microbiology
Lisa N. Kinch, R. Dustin Schaeffer, Jing Zhang, Qian Cong, Kim Orth, Nick Grishin
Summary: By utilizing structure-assisted homology detection, this study provides insights into the functional interpretation of proteins from the pandemic strain RIMD2210633 of Vibrio parahaemolyticus. The study identifies proteins originating from horizontal gene transfer, enriches the understanding of phage markers and bacterial defense domains in RIMD proteins, and highlights fast-evolving proteins potentially involved in virulence and phage avoidance.
Article
Biotechnology & Applied Microbiology
H. Oberti, G. Spangenberg, N. Cogan, R. Reyno, M. Feijoo, S. Murchio, M. Dalla-Rizza
Summary: By analyzing the whole genome sequences and in planta RNA-seq of Claviceps paspali isolates, unique probable secreted proteins and probable pathogenicity factors were identified. This information opens new avenues in the study of the biology of this fungus and how it modulates the interaction with its host. Knowledge of the diversity of the secretome and putative pathogenicity genes should facilitate future research in disease management of Claviceps spp.
Article
Chemistry, Applied
Yiran Wang, Qiya Yang, Esa Abiso Godana, Yu Zhang, Hongyin Zhang
Summary: In this study, the morphological changes of Penicillium expansum within apple wounds during the infection process were investigated. The study revealed that conidia swelled and secreted potential hydrophobin in 4 h, germinated in 8 h, and formed conidiophores in 36 h. The transcript accumulation of P. expansum in apple tissues and liquid culture at 12 h was also compared, revealing the up-regulation and down-regulation of genes related to the biosynthesis of substances and activation of pathways.
Article
Dermatology
Guanzhao Liang, Meijie Zhang, Wenqi Xu, Xiaowen Wang, Hailin Zheng, Huan Mei, Weida Liu
Summary: This study revealed the differences in pathogenicity among the four Mucorales species and their relationship with mitogenomic features. The sequencing and comparison of the mitogenomes of these species uncovered structural and functional variations, indicating potential differences in pathogenicity mechanisms. Future research should focus on the spatial structure of mitochondrial genomes and comprehensive analysis of transcription regulation for a deeper understanding.
Article
Plant Sciences
Zikai Xiang, Daiki Okada, Soichiro Asuke, Hitoshi Nakayashiki, Kenichi Ikeda
Summary: This study evaluated the tissue-specific infection strategies of Pyricularia oryzae and Pyricularia grisea in various gramineous plants. The results showed that the degree of root browning caused by mycelial plug inoculation did not simply follow the disease index on leaves. Different host plants and pathotype also exhibited differences in the localization of infection hyphae in roots. Resistance reactions were induced in the roots of gramineous plants against the infection but failed to prevent fungal invasion.
MOLECULAR PLANT PATHOLOGY
(2022)
Article
Microbiology
Xiaodan Tan, Xiaoqiu Dai, Ting Chen, Yushuang Wu, Dong Yang, Yixiong Zheng, Huilan Chen, Xiaorong Wan, Yong Yang
Summary: This study made significant progress in understanding the molecular mechanism of peanut-Ralstonia solanacearum interaction by comparing the genomic differences between different strains of the bacterium. The identification of candidate effectors responsible for the difference in pathogenicity between the strains provides valuable insights for future control strategies.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria F. Palafox, Heta S. Desai, Valerie A. Arboleda, Keriann M. Backus
Summary: The integration of chemoproteomics data with computational methods for predicting genetic variant pathogenicity revealed enrichment of deleterious genetic variants in codons of highly reactive cysteines. This study provides a roadmap for more precise inter-database mapping and highlights untapped opportunities to improve the predictive power of pathogenicity scores and prioritize putative druggable sites.
MOLECULAR SYSTEMS BIOLOGY
(2021)
Article
Microbiology
Yisong Li, Ying Wang, Jie Liu
Summary: This study provides the first genome sequence level description of Mobiluncus and sheds light on its virulence/pathogenicity, functional diversification, and evolutionary dynamics. The study suggests that horizontal gene transfer might be an important strategy for species diversification and pathogenicity.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Eilyn Mena, Silvia Garaycochea, Silvina Stewart, Marcos Montesano, Ines Ponce De Leon
Summary: In this study, the genomic and transcriptomic information of D. caulivora, a fungal pathogen causing stem canker in soybean, was analyzed to gain insights into its molecular basis of pathogenicity. The study revealed a large number of genes encoding secreted pathogenicity-related proteins in D. caulivora, and identified various factors related to host infection strategies, including plant cell wall degradation and modification, compound detoxification, transporter activities, and toxin production.
Article
Biotechnology & Applied Microbiology
Muhsin Jamal, Saadia Andleeb, Fazal Jalil, Muhammad Imran, Muhammad Asif Nawaz, Tahir Hussain, Muhammad Ali, Sadeeq Ur Rahman, Chythanya Rajanna Das
FOLIA MICROBIOLOGICA
(2019)
Review
Immunology
Aleena Haqqi, Rimsha Munir, Muhammad Khalid, Muhammad Khurram, Muhammad Zaid, Muhammad Ali, Zaheer Hussain Shah, Haroon Ahmed, Muhammad Sohail Afzal
Article
Plant Sciences
Shabina Iram, Muhammad Qasim Hayat, Muhammad Tahir, Alvina Gul, Abdullah, Ibrar Ahmed
Letter
Virology
Muhammad Ali, Muhammad Zaid, Muhammad Arif Nadeem Saqib, Haroon Ahmed, Muhammad Sohail Afzal
JOURNAL OF MEDICAL VIROLOGY
(2020)
Editorial Material
Plant Sciences
Aamir Lal, Eui-Joon Kil, Thuy Thi Bich Vo, Chairina Fadhila, Phuong Thi Ho, Malik Nawaz Shuja, Muhammad Ali, Sukchan Lee
Editorial Material
Plant Sciences
Aamir Lal, Eui-Joon Kil, Kainat Rauf, Muhammad Ali, Sukchan Lee
Article
Virology
Azkia Khan, Yaqoot Imtiaz, Muhammad Tahir, Rob W. Briddon
Summary: A newly identified begomovirus, hollyhock vein yellowing virus (HoVYV), was found in hollyhock plants in Punjab, Pakistan, showing low nucleotide sequence similarity to known begomoviruses. The betasatellite associated with the virus is related to cotton leaf curl disease, suggesting hollyhock's role as a reservoir of the cotton leaf curl begomovirus betasatellite complex.
ARCHIVES OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Naseeha Bibi, Najam-Us-Sahar Sadaf Zaidi, Muhammad Tahir, Mustafeez Mujtaba Babar
Summary: The study aimed to identify universally conserved antigenic regions of Haemophilus influenzae for developing new vaccines. Through comprehensive geno-proteomic analysis using bioinformatics tools, five predicted novel vaccine candidate target proteins were identified.
CANADIAN JOURNAL OF MICROBIOLOGY
(2021)
Article
Microbiology
Jaedeok Kim, Aamir Lal, Eui-Joon Kil, Hae-Ryun Kwak, Hwan-Su Yoon, Hong-Soo Choi, Mikyeong Kim, Muhammad Ali, Sukchan Lee
Summary: The study identified different isolates of Apple stem grooving virus in agricultural fields in South Korea, showing phylogenetic separation based on their host species rather than geography. Further analysis indicated that the virus followed host adaptation influenced by the host codon usage.
Article
Multidisciplinary Sciences
Nida Fatima Ali, Rehan Zafar Paracha, Muhammad Tahir
Summary: The study revealed significant interactions between the proteins of two viruses, particularly involving key proteins that play a crucial role in the viral life cycle and pathogenicity. This may suggest an antagonistic behavior between the two viruses and categorize the type of infection as a type of Super Infection Exclusion (SIE) or homologous interference. Further experimentation is needed to confirm the nature of these interactions and enhance the understanding of the direct interactions between the two viruses.
Article
Biochemistry & Molecular Biology
Rana Muhammad Mateen, Asma Tariq, Muhammad Sohail Afzal, Muhammad Ali, Imran Tipu, Mureed Hussain, Mahjabeen Saleem, Muhammad Naveed
Summary: The study presents a novel approach of inhibiting the nuclear localization signal to interrupt the nuclear translocation of TULP3, potentially offering a new drug target for cancer therapeutics based on in silico experiments.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Virology
Khalid Muhammad, Venura Herath, Khadija Ahmed, Muhammad Tahir, Jeanmarie Verchot
Summary: This study analyzed the phylogenetic relationship of sugarcane mosaic virus (SCMV) isolates from different geographical areas, identified four major isolate groups, and found geographical mismatches in the phylogenetic tree. Recombination analysis showed hot spots across most of the genome except in the coat protein coding region. Additionally, the study examined SCMV isolates from sugarcane and found that they predate isolates from all other hosts.
ARCHIVES OF VIROLOGY
(2022)
Article
Virology
Aamir Lal, Eui-Joon Kil, Thuy T. B. Vo, I. Gusti Ngurah Prabu Wira Sanjaya, Muhammad Amir Qureshi, Bupi Nattanong, Muhammad Ali, Malik Nawaz Shuja, Sukchan Lee
Summary: This study presents the molecular characterization of a novel recombinant begomovirus associated with Chenopodium album in Lahore, Pakistan. The virus showed extensive recombination between open reading frames (ORFs) from different origins. The infectious clone of the virus was found to be fully infectious in C. album and Nicotiana benthamiana, fulfilling Koch's postulates. Therefore, the tentative name 'Chenopodium leaf distortion virus' (CLDV) is proposed.
Article
Immunology
Naseeha Bibi, Amtul Wadood Wajeeha, Mamuna Mukhtar, Muhammad Tahir, Najam us Sahar Sadaf Zaidi
Summary: This study aimed to validate the capability of two synthetic peptide-based vaccines to induce immune responses against H. influenzae strains. The results showed that the combination of synthetic peptides and BG adjuvants produced the best results.
Article
Biochemistry & Molecular Biology
Rana Muhammad Mateen, Asma Tariq, Muhammad Ali, Muhammad Sohail Afzal, Zahoor Qadir Samra, Muhammad Amin Athar
MOLECULAR GENETICS MICROBIOLOGY AND VIROLOGY
(2020)
