Article
Biochemistry & Molecular Biology
Robert J. Webber, Richard M. Sweet, Douglas S. Webber
Summary: The study found that anti-MV-A iNOS monoclonal antibodies can mitigate the harmful effects of MV-A iNOS and increase the survival rate of mice challenged with sepsis. The efficacy of the treatment is both time- and dose-dependent. Humanized anti-MV-A iNOS mAbs could potentially save tens of thousands of lives annually and improve antibiotic stewardship.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Akbar Pasha, Divya Vishambhar Kumbhakar, Ravinder Doneti, Kiran Kumar, Gangappa Dharmapuri, Pavan Kumar Poleboyina, S. K. Heena, Preethi Basavaraju, Deepthi Pasumarthi, S. D. Annapurna, Pavani Soujanya, I. Arnold Emeson, Vijayalaxmi Bodiga, Smita C. Pawar
Summary: This study aimed to investigate the expression of inducible nitric oxide synthase (iNOS) in cervical cancer and identified a potential iNOS inhibitor. The research found that elevated iNOS levels were associated with poor survival and increased tumor aggressiveness in cervical cancer, and andrographolide may exert anti-cancer effects by inhibiting iNOS expression.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Immunology
Junfeng Zhang, Yunsheng Zhang, Zhiya Yang, Dalei Cheng, Hui Zhang, Li Wei, Chen Liu, Fenglian Yan, Chunxia Li, Guanjun Dong, Changying Wang, Dongmei Shi, Huabao Xiong
Summary: Although psoriasis is characterized as a T cell-mediated inflammatory disease, the role of myeloid cells in the development of psoriasis is not fully understood. This study found that the expression of the anti-inflammatory cytokine interleukin-35 (IL-35) was increased in patients with psoriasis, along with an increase in myeloid-derived suppressor cells (MDSCs). IL-35 reduced the number of MDSCs and ameliorated psoriasis. IL-35 also reduced the expression of inducible nitric oxide synthase in MDSCs. Overall, IL-35 may play a critical role in regulating iNOS-expressing MDSCs in psoriasis, suggesting IL-35 as a potential therapeutic strategy for psoriasis and other cutaneous inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Shang Xian Bo, Wang Yan Jie, Cai De Chao, Ma Sai, Wang Zhe, Zhu Ya Kun, Guo Hui Hui, Wang Chen, Ma Xiao, Hu Zhong Yao, Yu Hao Ran, Zhang Ji Sen, Cheng Wen Dan
Summary: The study demonstrated that compound 22o effectively inhibited the inflammatory response and catabolism of chondrocytes, reducing articular cartilage injury in a rat OA model induced by ACLT. The compound showed potential as a disease-modifying OA drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Ophelie Rutschmann, Chiara Toniolo, John D. McKinney
Summary: In this report, we demonstrated that fluctuations in the expression of antimicrobial genes can define how single host cells control bacterial infections. We showed that preexisting cell-to-cell variation in the expression of a single gene, that for inducible nitric oxide synthase, is sufficient to explain why some macrophages kill intracellular M. tuberculosis while others fail to control bacterial replication, possibly leading to disease progression. We introduced the concept that chance encounters between heterogeneous bacteria and host cells can determine the outcome of a host-pathogen interaction. This concept is particularly relevant for all the infectious diseases in which the number of interacting pathogens and host cells is small at some point during the infection.
Article
Endocrinology & Metabolism
Zhichao Zhou, Aida Collado, Changyan Sun, Yahor Tratsiakovich, Ali Mahdi, Hanna Winter, Ekaterina Chernogubova, Till Seime, Sampath Narayanan, Tong Jiao, Hong Jin, Michael Alvarsson, Xiaowei Zheng, Jiangning Yang, Ulf Hedin, Sergiu-Bogdan Catrina, Lars Maegdefessel, John Pernow
Summary: Red blood cells (RBC) play a role in vascular injury in type 2 diabetes mellitus (T2DM), and miR-210 is decreased in T2DM patients. This study shows that downregulation of RBC miR-210 induces endothelial dysfunction in T2DM. Transfection of miR-210 can rescue endothelial function, while inhibition of miR-210 impairs endothelial function. The downregulation of RBC miR-210 involves PTP1B and reactive oxygen species.
Article
Biochemistry & Molecular Biology
Shaimaa Maher, Lauren A. Smith, Celine A. El-Khoury, Haitham Kalil, Khalid Sossey-Alaoui, Mekki Bayachou
Summary: Nitric oxide (NO) is a small molecule that has a significant impact on various biological activities. It has been linked to cancer-related processes and has the potential to be used as an anti-cancer agent. In this study, NO-releasing materials were developed using modified sodium alginate hydrogel, which showed compatibility with cell growth. The release of NO from the hydrogel exhibited distinct kinetic features.
Article
Environmental Sciences
Dalia H. El-Kashef, Maha H. Sharawy
Summary: Nicorandil protects against acetaminophen-induced liver damage by reducing liver function indicators, inhibiting oxidative stress and inflammation, and improving cell survival.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Di Li, Jinlin He, Caihong Fang, Yiwen Zhang, Mingli He, Zhanqi Zhang, Jinsong Hou, Qiong Xu
Summary: Excessive differentiation of osteoclasts contributes to the disruption of bone homeostasis in inflammatory bone diseases. METTL3 deficiency leads to decreased osteoclast differentiation and increased apoptosis in inflammatory conditions, possibly due to the exacerbation of iNOS/NO-mediated mitochondrial dysfunction by promoting Nos2 mRNA stability in a YTHDF1-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Corina Daniela Ene, Ilinca Nicolae
Summary: This study explores the relationship between NOS2-associated inflammation profiles and SLE phenotypes. The variations in biomarkers are strongly associated with the decrease in eGFR and increase in albuminuria.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tetsuya Tachibana, Maki Takahashi, Sakirul Khan, Ryosuke Makino, Mark A. Cline
Summary: This study aimed to investigate the effects of virus component analogues on NO production in chicks and found that poly I:C and R848 significantly increased plasma NO concentrations and induced an increase in iNOS mRNA expression. The study also found that these virus analogues decreased mRNA expressions of endothelial NOS and neural NOS in several organs, suggesting that iNOS might be responsible for the increased plasma NO levels. These findings suggest that viral infections facilitate NO production by inducing iNOS and are associated with corticosterone release in birds.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Cell Biology
Peng Zhang, Huyue Fang, Chengjian Lou, Shan Ye, Guanghong Shen, Shijia Chen, Nashwa Amin, Benson O. A. Botchway, Marong Fang
Summary: This study investigated the changes in brain markers in spontaneously hypertensive rats at different ages and found potential factors related to the pathogenesis of ADHD. The upregulation of Iba-1 in the senescent stage, alterations in nNOS expression at different stages, and age-related astrogliosis were observed, suggesting their contribution to ADHD pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Agnieszka Zablocka, Dominika Jakubczyk, Katarzyna Leszczynska, Katarzyna Pacyga-Prus, Jozefa Macala, Sabina Gorska
Summary: This study investigated the ability of Bifidobacterium species to induce iNOS-dependent NO synthesis in macrophages. The results showed that Bifidobacterium can regulate the expression of iNOS and produce NO by activating MAPK kinases. TLR2 and TLR4 receptors are involved in Bifidobacterium-induced macrophage activation and NO production. The study suggests that Bifidobacterium has a protective mechanism in the intestine, and its efficacy is strain-dependent.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biochemistry & Molecular Biology
Deepali Singh, Archana Yadav, Chetna Singh
Summary: The study revealed that iNOS and CYP2E1 in rat PMNs contribute to oxidative stress induced by MB+PQ through differential regulatory mechanisms, with iNOS being regulated by inflammatory mediators and CYP2E1 expression triggered via the MEK-ERK1/2-PKC pathway.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Oncology
Ana C. Luque-Badillo, Griselda Hernandez-Tapia, Dhamar A. Ramirez-Castillo, Diego Espinoza-Serrano, Alan M. Cortes-Limon, Juan P. Cortes-Gallardo, Daniel A. Jacobo-Velazquez, Margarita L. Martinez-Fierro, Clara P. Rios-Ibarra
Summary: The study demonstrated that chlorogenic acid can inhibit the expression of miR-31 in colon cancer cells, while gold nanoparticles enhance miR-31 detection. This suggests a potential new strategy for developing non-invasive tools for molecular diagnosis and monitoring of colon cancer.
Article
Endocrinology & Metabolism
Nory O. Davalos-Rodriguez, Ana Rosa Rincon-Sanchez, Perla Montserrat Madrigal Ruiz, Luis Javier Flores-Alvarado, Sabina Lopez-Toledo, Jose Rafael Villafan-Bernal, Carlos J. Castro-Juarez, Rufina Guzman-Lopez, Jose Isaias Siliceo-Murrieta, Sergio Alberto Ramirez-Garcia
Summary: The study found that the VNTR of the ATXN2 gene is associated with obesity in Mexican adults of Chinantec ancestry, and there are differences in waist/hip circumference index and body mass index.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2022)
Letter
Surgery
Maria E. Aguilar-Aldrete, Jose Dominguez-Rodas, Carlos E. Cabrera-Pivaral, Nemesio Villa-Ruano, Sabina Lopez-Toledo, Nory O. Davalos-Rodriguez, Ana R. Rincon-Sanchez, Erick Ruiz-Balderas, Sergio A. Ramirez-Garcia
CIRUGIA Y CIRUJANOS
(2022)
Letter
Surgery
Jose Dominguez-Rodas, Sergio A. Ramirez-Garcia, Ana R. Rincon-Sanchez, Nory O. Davalos-Rodriguez, Melecio H. Juarez-Perez, Carlos E. Cabrera-Pivaral
CIRUGIA Y CIRUJANOS
(2022)
Letter
Medicine, General & Internal
Carlos E. Cabrera Pivaral, Ana Rosa Rincon Sanchez, Sergio Alberto Ramirez-Garcia
Article
Genetics & Heredity
Carlos Cordova-Fletes, Horacio Rivera, Thania Alejandra Aguayo-Orozco, Lizeth Alejandra Martinez-Jacobo, Elvira Garza-Gonzalez, Carla Daniela Robles-Espinoza, Patricia Basurto-Lozada, Hector-Gerardo Avalos-Gomez, Eduardo Esparza-Garcia, Ma Guadalupe Dominguez-Quezada
Summary: Germline or constitutional chromoanagenesis-related complex chromosomal rearrangements (CCRs) are rare and catastrophic events that involve chromothripsis and chromoplexy. In this study, a patient with a phenotype resembling MRD44 was found to have a complex t(5;7;21)dn rearrangement involving multiple disordered breakpoints. Whole-genome sequencing revealed disruptions in several neurodevelopmental genes, with the disruption of TRIO most likely contributing to the patient's phenotype.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Dermatology
Paulene Sapao, Elisha D. O. Roberson, Bo Shi, Shervin Assassi, Brian Skaug, Fred Lee, Alexandra Naba, Bethany E. Perez White, Carlos Cerdova-Fletes, Pei-Suen Tsou, Amr H. Sawalha, Johann E. Gudjonsson, Feiyang Ma, Priyanka Verma, Dibyendu Bhattacharyya, Mary Carns, Jerome F. Strauss III, Delphine Sicard, Daniel J. Tschumperlin, Melissa I. Champer, Paul J. Campagnola, Maria E. Teves, John Varga
Summary: Systemic sclerosis (SSc) is a fibrotic disease with no effective treatment. This study found that SPAG17 expression was downregulated in SSc patients and negatively correlated with fibrotic gene expression. Further experiments revealed that reduced chromatin accessibility at the SPAG17 locus was observed in SSc fibroblasts and endothelial cells. Knock-down of SPAG17 resulted in myofibroblast transformation and increased sensitivity to profibrotic stimuli. These findings provide important insights into the pathogenesis of SSc and suggest SPAG17 as a potential target for developing innovative therapies for fibrotic conditions.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Infectious Diseases
Ulises Garza-Ramos, Jesus Silva-Sanchez, Luis Esau Lopez-Jacome, Melissa Hernandez-Duran, Claudia Adriana Colin-Castro, Alejandro Sanchez-Perez, Jonathan Rodriguez-Santiago, Rayo Morfin-Otero, Eduardo Rodriguez-Noriega, Maria-del-Consuelo Velazquez-Acosta, Maria Del Rosario Vazquez-Larios, Jose Manuel Feliciano-Guzman, Fabian Rojas-Larios, Alfredo Ponce-De-Leon, Margarita Lozano-Garcia, Elena Victoria Choy-Chang, Eduardo Lopez-Gutierrez, Aaron Molina-Jaimes, Mariana Gil-Veloz, Reyna Edith Corte-Rojas, Ismelda Lopez-Ovilla, Jose Luis Ramirez-Mis, Dora Elia Rodriguez-Balderas, Alejandro Molina-Chavarria, Cecilia Padilla-Ibarra, Maria Angelina Quevedo-Ramos, Christian Daniel Mireles-Davalos, Nadia Rodriguez-Medina, Daira Rubio-Mendoza, Carlos Cordova-Fletes, Flora Cruz-Lopez, Dilva Angelina Becerra-Montejano, Roberto Mercado-Longoria, Rebeca Thelma Martinez-Villarreal, Nicolas Rogelio Eric Barlandas-Rendon, Juan Pablo Mena-Ramirez, Carlos Antonio Couoh-May, Margarita Alcaraz-Espejel, Cesar Adame-Alvarez, Lourdes Hernandez-Vicente, Elvira Garza-Gonzalez
Summary: In this study, carbapenemase-encoding genes and colistin resistance were detected in multiple bacterial species in the second year of the COVID-19 pandemic. The presence of highly virulent strains and the circulation of carbapenem-resistant genes in Mexico highlight the importance of understanding molecular resistance mechanisms in guiding antibiotic therapies. Overall, this study has a score of 8 out of 10 for its significance.
MICROBIAL DRUG RESISTANCE
(2023)
Review
Virology
Tania Guadalupe Heredia-Torres, Ana Rosa Rincon-Sanchez, Sonia Amelia Lozano-Sepulveda, Kame Galan-Huerta, Daniel Arellanos-Soto, Marisela Garcia-Hernandez, Aurora de Jesus Garza-Juarez, Ana Maria Rivas-Estilla
Summary: Viral infection-induced cancer is a major cause of cancer development, with HCV being a virus that causes chronic liver infection. The virus promotes liver cancer development through various molecular mechanisms, but recent treatments with DAAs have also shown an increased risk of early HCC occurrence in some cases. Therefore, a better understanding of molecular mechanisms and therapeutic targets is crucial.
Article
Medicine, General & Internal
Arturo Caballero-Avendano, Sergio A. Ramirez-Garcia, Melva Gutierrez-Angulo, Carlos E. Cabrera-Pivaral, Nory O. Davalos-Rodriguez, Ana R. Rincon-Sanchez
Summary: Colorectal cancer is a complex disease influenced by genetic, environmental, and lifestyle factors. Most cases of this cancer develop gradually over time, with genetic factors playing a significant role. Environmental risk factors such as obesity, lack of physical activity, consumption of red and processed meats, alcoholism, and smoking are associated with the 13-catenin signaling pathway. To prevent CRC, it is recommended to reduce risk factors, increase intake of fruits, vegetables, and grains, exercise regularly, and limit alcohol and tobacco consumption. Regular examinations, including the use of biochemical and molecular markers, are suggested for individuals with a family history or hereditary syndrome.
GACETA MEDICA DE MEXICO
(2023)
Article
Infectious Diseases
Ulises Garza-Ramos, Nadia Rodriguez-Medina, Carlos Cordova-Fletes, Daira Rubio-Mendoza, Christopher J. Alonso-Hernandez, Luis Esau Lopez-Jacome, Rao Morfin-Otero, Eduardo Rodriguez-Noriega, Fabian Rojas-Larios, Maria del Rosario Vazquez-Larios, Alfredo Ponce-de-Leon, Elena Victoria Choy-Chang, Rafael Franco-Cendejas, Bernardo Alfonso Martinez-Guerra, Cecilia Teresita Morales-de-La-Pena, Juan Pablo Mena-Ramirez, Eduardo Lopez-Gutierrez, Ricardo Garcia-Romo, Bertha Ballesteros-Silva, Alejandro Valadez-Quiroz, Laura Karina Aviles-Benitez, Jose Manuel Feliciano-Guzman, Talia Perez-Vicelis, Maria del Consuelo Velazquez-Acosta, Cecilia Padilla-Ibarra, Laura Isabel Lopez-Moreno, Reyna Edith Corte-Rojas, Carlos Antonio Couoh-May, Maria Angelina Quevedo-Ramos, Maribel Lopez-Garcia, Gabriela Chio-Ortiz, Mariana Gil-Veloz, Alejandro Molina-Chavarria, Javier Paul Mora-Dominguez, Daniel Romero-Romero, Francisco Javier May-Tec, Elvira Garza-Gonzalez
Summary: This study aimed to analyze the genomic characteristics and molecular epidemiology of carbapenem nonsusceptible Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa from medical centers in Mexico using whole genome sequencing data. The EPISEQ CS application and other bioinformatic platforms were utilized for analysis. The study found that EPISODE CS enabled a comprehensive resistance and virulence analysis, providing a reliable method for bacterial strain typing and characterization of the virulome and resistome.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Article
Medical Laboratory Technology
Clara Patricia Rios-Ibarra, Barbara Verduzco-Garza, Rocio Ortiz-Lopez, Yohann Grondin, Mauricio Salinas-Santander, Luis Alberto Arvizu-Gutierrez, Monica Gabriela Sanchez-Salazar, Enrique Cervantes-Astorga, Danielle A. Orozco-Nunnelly, Ana Maria Rivas-Estilla
Summary: This study demonstrated that acetylsalicylic acid (ASA) regulates the expression of non-structural hepatitis C virus (HCV) proteins in hepatocellular carcinoma cells. ASA can modulate the expression of genes with oxidative roles, with IL-8, CYP450, and MTs genes upregulated and RRs genes downregulated. This suggests that ASA may interfere with HCV replication by altering the antioxidant microenvironment.
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2022)
Article
Oncology
Elda A. Flores-Contreras, Everardo Gonzalez-Gonzalez, Ana I. Zarazua-Nino, Elsa N. Garza-Trevino, Natalia Martinez-Acuna, Viviana C. Zomosa-Signoret, Roman Vidaltamayo, Gerardo E. Munoz-Maldonado, Raquel Garza-Guajardo, Manuel de J. Garcia-Solis, Alejandro Abarca-Blanco, Ana M. G. Rivas-Estilla, Carlos Cordova-Fletes
Summary: This study identified a lncRNA, lnc-ERP44-3:6, which was significantly down-regulated in breast tumor tissues of BC patients. Overexpression of this lncRNA resulted in increased cell death and chemosensitivity in breast cancer cell lines.
Article
Biochemistry & Molecular Biology
Elsie Guadalupe Hernandez-Lopez, Gracia Viviana Gonzalez-Enriquez, Blanca Miriam Torres-Mendoza, Jhonathan Cardenas-Bedoya, Martha Escoto-Delgadillo, Eduardo Vazquez-Valls, Alma Minerva Perez-Rios, David Alejandro Carbajal-Uribe, Ana Rosa Rincon-Sanchez
Summary: The study compared the expression levels of SERINC5 in individuals with HIV and those without, finding downregulation of SERINC5 in the HIV-infected group.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Geriatrics & Gerontology
M. A. Mora-Navarro, A. R. Rincon-Sanchez, F. P. Pacheco-Moises, M. A. Mireles-Ramirez, D. L. C. Delgado-Lara, B. M. Torres-Mendoza, I. E. Velazquez-Brizuela, G. Gabriel Ortiz
Summary: Although disease-modifying factors such as malnutrition and diet have been associated with Alzheimer's disease, little is known about the effects of pharmacological therapies on the nutritional status of AD patients. A cross-sectional study was conducted to evaluate the nutritional status and anthropometric measurements in AD patients with and without rivastigmine treatment. The study found that rivastigmine treatment has a protective effect on malnutrition in patients with moderate-stage AD, showing improvements in appetite, psychological stress, mobility, and independence.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)