Journal
ARCHIVES OF VIROLOGY
Volume 159, Issue 12, Pages 3365-3370Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-014-2186-0
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Funding
- National High Technology Research and Development Program 863 of China [2011AA02A115]
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Human papillomavirus (HPV) is associated with cervical cancer. In this study, we developed a high-throughput microwell-plate hybrid capture (MPHC) method for epidemiological studies of high-risk HPV (HRHPV). The results with 1238 cervical specimens from female outpatients showed a concordance rate of 94.3 % between the MPHC and Hybrid Capture II assay. The MPHC assay showed an average HRHPV rate of 29.3 % for high-risk populations in populous cities of China. The established MPHC assay could sensitively and specifically detect 13 types of HRHPV and is suitable for large-scale screening, especially in areas where real-time PCR or fluorescence equipment is unavailable.
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