Article
Immunology
Dongliang Liu, Sheng Zhang, Ethan Poteet, Christian Marin-Muller, Changyi Chen, Qizhi Yao
Summary: In the development of HIV vaccines, incorporating C1q into CD40L/HIV VLP and immunizing through sublingual administration can effectively enhance mucosal and systemic immune responses, induce more vaccine-specific T cells, and show promising research and application value.
Article
Virology
Poonsook Keelapang, Chutitorn Ketloy, Chunya Puttikhunt, Rungtawan Sriburi, Eakachai Prompetchara, Malinee Sae-Lim, Bunpote Siridechadilok, Thaneeya Duangchinda, Sansanee Noisakran, Nicha Charoensri, Prapat Suriyaphol, Piyanan Suparattanagool, Utaiwan Utaipat, Promsin Masrinoul, Panisadee Avirutnan, Juthathip Mongkolsapaya, Gavin Screaton, Prasert Auewarakul, Suchinda Malaivijitnond, Sutee Yoksan, Prida Malasit, Kiat Ruxrungtham, Rojjanaporn Pulmanausahakul, Nopporn Sittisombut
Summary: This study investigated the induction of protective antibody responses against dengue virus infection in a non-human primate model using a heterologous prime-boost vaccination approach. The results showed that all macaques had elevated levels of neutralizing antibodies after 1 month of immunization, and the overall protective efficacy against clinical isolates reached 91%.
JOURNAL OF VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Xueyang Guo, Alexandra Kazanova, Stephanie Thurmond, H. Uri Saragovi, Christopher E. Rudd
Summary: The study introduces an alternative approach to treat COVID-19 using CAR-T cells, which recognize the RBD peptide of SARS-CoV-2, induce cellular activation, and effectively kill virus-infected cells, demonstrating promising potential in combating the disease.
Article
Immunology
Yi-Ling Cheng, Chiao-Hsuan Chao, Yen-Chung Lai, Kun-Han Hsieh, Jen-Ren Wang, Shu-Wen Wan, Hong-Jyun Huang, Yung-Chun Chuang, Woei-Jer Chuang, Trai-Ming Yeh
Summary: This study confirms the presence of antibodies related to SARS-CoV-2 in dengue virus patients, and these antibodies can cross-react with proteins of the dengue virus. These antibodies can inhibit the pathological reactions caused by dengue virus infection, potentially providing some level of protection against dengue virus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
N. Veena Rani, Neera Kapoor, Anuja Krishnan
Summary: This study explores the importance of utilizing viral-like particles (VLPs) for diagnostics, drug delivery, and vaccine production, as well as their role as a model system for studying virus assembly and fusion processes. By replacing certain regions of the E protein of Dengue virus (DENV) with corresponding regions of the G protein of Vesicular Stomatitis virus (VSV), chimeric VLPs were generated that showed higher levels of VLP production compared to the wild type. These chimeric VLPs also demonstrated effective recognition by dengue-infected patient sera, suggesting their potential for vaccine production and serodiagnosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Lingshu Wang, Tongqing Zhou, Yi Zhang, Eun Sung Yang, Chaim A. Schramm, Wei Shi, Amarendra Pegu, Olamide K. Oloniniyi, Amy R. Henry, Samuel Darko, Sandeep R. Narpala, Christian Hatcher, David R. Martinez, Yaroslav Tsybovsky, Emily Phung, Olubukola M. Abiona, Avan Antia, Evan M. Cale, Lauren A. Chang, Misook Choe, Kizzmekia S. Corbett, Rachel L. Davis, Anthony T. DiPiazza, Ingelise J. Gordon, Sabrina Helmold-Hait, Tandile Hermanus, Prudence Kgagudi, Farida Laboune, Kwanyee Leung, Tracy Liu, Rosemarie D. Mason, Alexandra F. Nazzari, Laura Novik, Sarah O'Connell, Sijy O'Dell, Adam S. Olia, Stephen D. Schmidt, Tyler Stephens, Christopher D. Stringham, Chloe Adrienna Talana, I-Ting Teng, Danielle A. Wagner, Alicia T. Widge, Baoshan Zhang, Mario Roederer, Julie E. Ledgerwood, Tracy J. Ruckwardt, Martin R. Gaudinski, Penny L. Moore, Nicole A. Doria-Rose, Ralph S. Baric, Barney S. Graham, Adrian B. McDermott, Daniel C. Douek, Peter D. Kwong, John R. Mascola, Nancy J. Sullivan, John Misasi
Summary: The study identified four receptor binding domain-targeting antibodies with potent neutralizing activity against 23 variants, including two ultrapotent antibodies. Combinations of these antibodies reduced the in vitro generation of escape mutants, showing potential in mitigating resistance development.
Article
Multidisciplinary Sciences
Whitney R. Baldwin, Holli A. Giebler, Janae L. Stovall, Ginger Young, Kelly J. Bohning, Hansi J. Dean, Jill A. Livengood, Claire Y. -H. Huang
Summary: The researchers developed a live-attenuated Zika vaccine based on a clinically proven dengue virus serotype-2 vaccine backbone and demonstrated that a single dose can protect mice and non-human primates from Zika virus infection.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Somanath Kallolimath, Lin Sun, Roman Palt, Karin Stiasny, Patrick Mayrhofer, Clemens Gruber, Benjamin Kogelmann, Qiang Chen, Herta Steinkellner
Summary: Monoclonal antibodies that neutralize SARSCoV-2 have been developed rapidly, but the diverse functions of different antibody subclasses in SARS-CoV-2 immunity are not well understood. Study shows that all IgG subclasses can neutralize the virus, with IgG3 exhibiting the highest potency, suggesting a strong protective effect.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Maria Agallou, Maritsa Margaroni, Evdokia Karagouni
Summary: In this study, the protective efficacy of liposomal LiChimera against experimental visceral leishmaniasis was investigated. It was found that liposomal LiChimera significantly reduced the parasite loads in the spleen and liver, indicating its potential as an effective candidate vaccine against visceral leishmaniasis.
Article
Virology
Nurfatihah Zulkifli, Jasmine-Elanie Khairat, Adzzie-Shazleen Azman, Nur-Faralyza Mohd Baharudin, Nurul-Adila Malek, Syafiq-Asnawi Zainal Abidin, Sazaly Abubakar, Pouya Hassandarvish
Summary: This study investigated the antiviral properties of Streptomyces sp. KSF 103 methanolic extract (Streptomyces KSF 103 ME) against dengue virus serotype 2 (DENV-2). The extract showed maximum inhibitory properties during the virus entry stage. Minimal antiviral activities were observed at other virus replication stages. Further studies are needed to understand the antiviral mechanisms of Streptomyces KSF 103 ME against DENV.
Article
Medicine, Research & Experimental
Irina Ushach, Ren Zhu, Elen Rosler, Rajendra K. Pandey, N. Tilani S. De Costa, Soheil Pourshahian, Qinglin Han, Chris Li, Leonid Beigelman, Sergei M. Gryaznov, Theodore Yun
Summary: The study aimed to design a novel immunomodulator to subvert immune tolerance to HBV, showing promising results in inducing strong immune responses against the virus by targeting CpG oligonucleotide to lymphoid organs in a mouse model of chronic HBV infection.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Medicine, Research & Experimental
Wen-Hung Wang, Aspiro Nayim Urbina, Chih-Yen Lin, Zih-Syuan Yang, Wanchai Assavalapsakul, Arunee Thitithanyanont, Po-Liang Lu, Yen-Hsu Chen, Sheng-Fan Wang
Summary: The development of dengue vaccines is crucial in preventing and controlling the global health threat caused by Dengue virus. Current approved vaccines have demonstrated low efficacy in certain populations, leading to ongoing investigation and development of novel strategies for dengue vaccines.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Michelle Felicia Lee, Guan Zhong Voon, Hui Xuan Lim, Mun Lok Chua, Chit Laa Poh
Summary: Dengue is a mosquito-borne disease that poses significant public health concerns in tropical and subtropical countries. The dengue virus has evolved various strategies to manipulate the host's immune responses, and miRNAs and DENV non-structural proteins (NS) are promising targets for anti-dengue therapeutics.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Jessamine E. Hazlewood, Bing Tang, Kexin Yan, Daniel J. Rawle, Jessica J. Harrison, Roy A. Hall, Jody Hobson-Peters, Andreas Suhrbier
Summary: A chimeric flavivirus vaccine based on Binjari virus was developed and utilized to generate a chimeric ZIKV vaccine. Vaccination with the unadjuvanted chimeric vaccine induced long-lasting neutralizing antibody responses and provided full protection against ZIKV infection in mice.
Article
Materials Science, Biomaterials
Rafiq Ahmad Khan, Farhan Ahmed, Sumbul Afroz, Nooruddin Khan
Summary: This study introduced a new strategy of encapsulating the EDIII domain of all serotypes of DENV into PLGA nanoparticles, and the tetravalent nano formulation combined with TLR agonists showed enhanced immunological efficacy, triggering robust antibody responses and improved production of serotype-specific neutralizing antibodies.
BIOMATERIALS SCIENCE
(2022)
Article
Virology
Iris Valdes, Lazaro Gil, Laura Lazo, Ernesto Marcos, Jorge Martin, Edith Suzarte, Jorge Castro, Yaremis Romero, Gerardo Guillen, Lisset Hermida
ARCHIVES OF VIROLOGY
(2016)
Article
Immunology
Edith Suzarte, Lazaro Gil, Iris Valdes, Ernesto Marcos, Laura Lazo, Alienys Izquierdo, Angelica Garcia, Lazaro Lopez, Maylin Alvarez, Yusleydis Perez, Jorge Castro, Yaremis Romero, Maria G. Guzman, Gerardo Guillen, Lisset Hermida
INTERNATIONAL IMMUNOLOGY
(2015)
Article
Immunology
Ernesto Marcos, Laura Lazo, Lazaro Gil, Alienys Izquierdo, Edith Suzarte, Iris Valdes, Aracelys Blanco, Julio Ancizar, Jose Suarez Alba, Yusleydis de la C. Perez, Karen Cobas, Yaremis Romero, Gerardo Guillen, Maria G. Guzman, Lisset Hermida
IMMUNOLOGY LETTERS
(2016)
Article
Immunology
Lazaro Gil, Karem Cobas, Laura Lazo, Ernesto Marcos, Laura Hernandez, Edith Suzarte, Alienys Izquierdo, Iris Valdes, Aracelys Blanco, Pedro Puentes, Yaremis Romero, Yusleidi Perez, Maria G. Guzman, Gerardo Guillen, Lisset Hermida
JOURNAL OF IMMUNOLOGY
(2016)
Article
Virology
Alienys Izquierdo, Angelica Garcia, Laura Lazo, Lazaro Gil, Ernesto Marcos, Mayling Alvarez, Iris Valdes, Lisset Hermida, Gerardo Guillen, Maria G. Guzman
ARCHIVES OF VIROLOGY
(2014)
Article
Virology
Edith Suzarte, Ernesto Marcos, Lazaro Gil, Iris Valdes, Laura Lazo, Yassel Ramos, Yusleidi Perez, Viviana Falcon, Yaremis Romero, Maria G. Guzman, Sirenia Gonzalez, Juan Kouri, Gerardo Guillen, Lisset Hermida
ARCHIVES OF VIROLOGY
(2014)
Article
Cell Biology
Lazaro Gil, Ernesto Marcos, Alienys Izquierdo, Laura Lazo, Iris Valdes, Penis Ambala, Lucy Ochola, Rikoi Hitler, Edith Suzarte, Mayling Alvarez, Prisilla Kimiti, James Ndung'u, Thomas Kariuki, Maria Guadalupe Guzman, Gerardo Guillen, Lisset Hermida
IMMUNOLOGY AND CELL BIOLOGY
(2015)
Article
Immunology
Laura Lazo, Alienys Izquierdo, Edith Suzarte, Lazaro Gil, Iris Valdes, Ernesto Marcos, Mayling Alvarez, Yaremis Romero, Maria Guadalupe Guzman, Gerardo Guillen, Lisset Hermida Cruz
MICROBIOLOGY AND IMMUNOLOGY
(2014)
Article
Biotechnology & Applied Microbiology
Iris Valdes, Alienys Izquierde, Karem Cobas, Phuong Thao, Hoang Anh Duc, Hoang Duc Loc, Le Trung Dung, Laura Lazo, Edith Suzarte, Yusleidi Perez, Yaremis Romero, Melyssa Yaugel, Ernesto Marcos, Maria G. Guzman, Do Tuan Oat, Nguyen Dan Hien, Gerardo Guilien, Lazar Gil, Lisset Hermida
JOURNAL OF GENERAL VIROLOGY
(2019)
Article
Virology
Iris Valdes, Ernesto Marcos, Edith Suzarte, Yusleidi Perez, Enma Brown, Laura Lazo, Karem Cobas, Melyssa Yaugel, Yadira Rodriguez, Lazaro Gil, Gerardo Guillen, Lisset Hermida
ARCHIVES OF VIROLOGY
(2017)