Journal
ARCHIVES OF VIROLOGY
Volume 155, Issue 1, Pages 117-121Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-009-0546-y
Keywords
Hantavirus (Bunyaviridae); Tula virus; Nonstructural (NSs) protein
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Funding
- University of Helsinki
- Academy of Finland
- Sigrid Juselius Foundation, Helsinki
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The small RNA segment of some hantaviruses (family Bunyaviridae) encodes two proteins: the nucleocapsid protein and, in an overlapping reading frame, a non-structural (NSs) protein. The hantavirus NSs protein, like those of orthobunya- and phleboviruses, counteracts host innate immunity. Here, for the first time, the NSs protein of a hantavirus (Tula virus) has been observed in infected cells and shown to localize in the perinuclear area. Transiently expressed NSs protein showed similar localization, although the kinetics was slightly different, suggesting that to reach its proper location in the infected cell, the NSs protein does not have to cooperate with other viral proteins.
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