Article
Immunology
Qun Zhang, Yuan Dai, Hongda Liu, Wenkui Sun, Yuming Huang, Zheng Gong, Shanlin Dai, Hui Kong, Weiping Xie
Summary: This retrospective cohort study aimed to determine the time-dependent death hazards of various causes and conditional survival of lung cancer. The study found that non-lung cancer related death risk becomes more predominant over time, and established a personalized web-based calculator to determine the critical time point for long-term survivors. The study also confirmed the survival benefit of advanced lung cancer patients in the era of immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Siena Roat-Shumway, Celsa M. Tonelli, Marshall S. Baker, Zaid M. Abdelsattar
Summary: This study demonstrates that surgical resection of small pulmonary carcinoids improves overall survival compared to observation. Within surgical resection, wedge and anatomic resection result in similar survival, and lymph node sampling improves survival.
ANNALS OF THORACIC SURGERY
(2023)
Article
Gastroenterology & Hepatology
Theodoros Michelakos, Yurie Sekigami, Filippos Kontos, Carlos Fernandez-del Castillo, Motaz Qadan, Vikram Deshpande, David T. Ting, Jeffrey W. Clark, Colin D. Weekes, Aparna Parikh, David P. Ryan, Jennifer Y. Wo, Theodore S. Hong, Jill N. Allen, Onofrio Catalano, Andrew L. Warshaw, Keith D. Lillemoe, Cristina R. Ferrone
Summary: Analysis of resected BR/LA PDAC patients treated with TNT shows that the probability of surviving an additional length of time increases as a function of survival already accrued, allowing for personalized follow-up and counseling.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Mathematical & Computational Biology
Pal C. Ryalen, Bjorn Moller, Christoffer H. Laache, Mats J. Stensrud, Kjetil Roysland
Summary: This article presents a method for estimating prognosis parameters for cancer survivors by utilizing differential equations driven by cumulative hazards. The parameters are expressed as solutions to these equations, allowing for the development of generic estimators that can be easily implemented with standard statistical software. Estimators for commonly used prognosis parameters in practice are explicitly described, as well as parameters that have not been previously used for prognosis evaluation. These parameters are then applied to assess the prognosis of five common cancers in Norway.
Article
Oncology
Sandi L. Pruitt, Anna Tavakkoli, Hong Zhu, Daniel F. Heitjan, David E. Gerber, Amit G. Singal, Ethan A. Halm, Muhammad Shaalan Beg, Bhumika Maddineni, Ankit J. Kansagra, Caitlin C. Murphy
Summary: Pancreas cancer patients who have previously had another cancer have similar survival rates to those without previous cancer, suggesting that cancer survivors should be considered for inclusion in pancreas cancer clinical trials.
Article
Oncology
Jianing Luo, Xiaonan Hu, Xiaofeng Ge
Summary: This study used conditional survival (CS) analysis to clarify the improvement of overall survival (OS) over time in young non-metastatic nasopharyngeal carcinoma (NPC) survivors and developed a CS-nomogram for real-time prognosis. The results showed a continuous increase in survival rate for young non-metastatic NPC patients during follow-up. A CS-nomogram was constructed using predictors identified through LASSO regression, which accurately estimated the real-time prognosis of survivors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Ryan Kahn, Olga Filippova, Sushmita Gordhandas, Anjile An, Alli M. Straubhar, Oliver Zivanovic, Ginger J. Gardner, Roisin E. O'Cearbhaill, William P. Tew, Rachel N. Grisham, Yukio Sonoda, Kara Long Roche, Nadeem R. Abu-Rustum, Dennis S. Chi
Summary: This study assessed a conditional probability of survival model to determine the probability of living 10 years after ovarian cancer diagnosis after already surviving 5 years. The results showed that the conditional probability of survival model provided better prediction of survival for long-term survivors with high-grade epithelial ovarian cancer compared to conventional methods.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Caitlin A. Hester, Giampaolo Perri, Laura R. Prakash, Jessica E. Maxwell, Naruhiko Ikoma, Michael P. Kim, Ching-Wei D. Tzeng, Brandon Smaglo, Robert Wolff, Milind Javle, Michael J. Overman, Jeffrey E. Lee, Matthew H. G. Katz
Summary: This study demonstrates that changes in tumor volume and serum levels of CA 19-9 are reliable metrics for assessing the response to systemic chemotherapy in patients with localized pancreatic cancer who do not undergo pancreatectomy. Best responders have significantly longer overall survival compared to nonresponders and other patients.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Oncology
Ifeanyichukwu Ogobuiro, Amber L. Collier, Khadeja Khan, Iago de Castro Silva, Deukwoo Kwon, Gregory C. Wilson, Patrick B. Schwartz, Alexander A. Parikh, Chet Hammill, Hong J. Kim, David A. Kooby, Daniel Abbott, Shishir K. Maithel, Rebecca A. Snyder, Syed A. Ahmad, Nipun B. Merchant, Jashodeep Datta
Summary: Black patients undergoing pancreatectomy are less likely to experience major pathologic response (MPR) following neoadjuvant therapy (NAT). Black race is independently associated with worse MPR, but there is no significant difference in disease-free survival (DFS) or overall survival (OS) between Black and non-Black patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Ifeanyichukwu Ogobuiro, Amber L. Collier, Khadeja Khan, Iago de Castro Silva, Deukwoo Kwon, Gregory C. Wilson, Patrick B. Schwartz, Alexander A. Parikh, Chet Hammill, Hong J. Kim, David A. Kooby, Daniel Abbott, Shishir K. Maithel, Rebecca A. Snyder, Syed A. Ahmad, Nipun B. Merchant, Jashodeep Datta
Summary: This study investigated whether there are racial disparities in MPR rates following NAT in PDAC patients undergoing resection. The results showed that Black patients had significantly lower rates of MPR compared to non-Black patients, but there was no significant difference in DFS or OS.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Christopher W. Mangieri, Cristian D. Valenzuela, Ian B. Solsky, Richard A. Erali, Timothy Pardee, Caio Max S. Rocha Lima, Russell Howerton, Clancy J. Clark, Perry Shen
Summary: This study compared the survival outcomes of metastatic pancreatic cancer patients treated with CPI-613 and FOLFIRINOX to borderline-resectable cases undergoing curative resection. The results showed no significant differences in survival times between the two groups. Therefore, the study concluded that CPI-613 may have potential utility in potentially resectable pancreatic adenocarcinoma, but further research with more comparable study groups is needed.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Paul Riviere, Lucas K. Vitzthum, Vinit Nalawade, Rishi Deka, Timothy Furnish, Loren K. Mell, Brent S. Rose, Mark Wallace, James D. Murphy
Summary: This study validates a cancer opioid risk score that accurately predicts long-term opioid use in elderly cancer survivors. The risk score successfully categorizes patients into low-, moderate-, and high-risk groups with varying probabilities of long-term opioid use. Future research should focus on implementing these scores in clinical practice and assessing their impact on prescriber behavior and patient outcomes.
Review
Oncology
Keith Sigel, Mengxi Zhou, Yeun-Hee Anna Park, Tinaye Mutetwa, Girish Nadkarni, Celine Yeh, Paz Polak, Carlie Sigel, Thierry Conroy, Beata Juzyna, Mark Ychou, Tito Fojo, Juan P. Wisnivesky, Susan E. Bates
Summary: This study compared the efficacy of Gem/NabP and FOLFIRINOX in patients with advanced pancreatic cancer using Veterans Administration (VA) data, and found no significant difference in overall survival between the two treatment groups. Tumor growth analysis revealed similar growth parameter values for Gem/NabP and FOLFIRINOX, suggesting that Gem/NabP may be noninferior to FOLFIRINOX for survival outcomes in advanced pancreatic adenocarcinoma based on national VA data. Biomarker-based growth equations may be helpful in monitoring treatment response and predicting prognosis for pancreatic cancer.
SEMINARS IN ONCOLOGY
(2021)
Review
Surgery
S. van Roessel, B. Janssen, E. C. Soer, A. Farina Sarasqueta, C. S. Verbeke, C. Luchini, L. A. A. Brosens, J. Verheij, M. G. Besselink
Summary: This systematic review aimed to provide an overview of tumour response scoring systems in pancreatic cancer following preoperative chemo(radio)therapy and found multiple scoring systems but a lack of comparative studies. More comparative data on interobserver variability and prognostic significance of these scoring systems are needed for establishing best practice in the field.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Oncology
Angela C. Nolin, Chunqiao Tian, Chad A. Hamilton, Yovanni Casablanca, Nicholas W. Bateman, John K. Chan, Michele L. Cote, Craig D. Shriver, Matthew A. Powell, Neil T. Phippen, Thomas P. Conrads, G. Larry Maxwell, Kathleen M. Darcy
Summary: This study aims to develop conditional survival and risk-assessment estimates for uterine serous carcinoma (USC) to provide tools for annual survivorship counseling and care planning. The results showed that five-year survival rates increased with higher stages and longer follow-up, while the standardized mortality ratio decreased. Differences in the risk of death were observed between diagnosis and after surviving 5 years.
GYNECOLOGIC ONCOLOGY
(2022)