Article
Infectious Diseases
Luisa A. Denkel, Frank Schwab, Jorg Clausmeyer, Michael Behnke, Jennifer Golembus, Solvy Wolke, Petra Gastmeier, Christine Geffers
Summary: The study aimed to compare the effects of chlorhexidine, octenidine, or routine bathing with water and soap on CLABSI rates in ICUs. However, both antiseptic methods did not show a significant preventive effect on CLABSI rates in the ICU setting.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Microbiology
Mustapha M. Mustapha, Vatsala R. Srinivasa, Marissa P. Griffith, Shu-Ting Cho, Daniel R. Evans, Kady Waggle, Chinelo Ezeonwuka, Daniel J. Snyder, Jane W. Marsh, Lee H. Harrison, Vaughn S. Cooper, Daria Van Tyne
Summary: Healthcare-associated infections (HAIs) can lead to mortality, morbidity, and wastage of healthcare resources. This study used whole-genome sequencing to analyze the diversity of bacteria sampled from hospitalized patients at a single center. The study identified nearly 100 different bacterial species and revealed different rates of evolution among species. Antibiotic resistance genes and mobile genetic elements were also frequently observed. This study provides valuable insights into the population structure and evolution of bacteria in healthcare settings and can inform efforts in outbreak detection and prevention.
Article
Immunology
Ahmed Babiker, Joseph D. Lutgring, Scott Fridkin, Mary K. Hayden
Summary: Chlorhexidine gluconate (CHG) is widely used in healthcare as an antiseptic with a good safety profile and broad spectrum of activity. Daily bathing with CHG has proven effective in preventing healthcare-associated infections and decolonizing multidrug-resistant pathogens. Despite the established benefits of CHG, concerns and unanswered questions remain regarding potential unintended microbial consequences of routine CHG bathing.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Nursing
Yen-Chin Chen, En-Ni Ku, Pei-Fang Tsai, Cheng-Man Ng, Jiun-Ling Wang, Che-Wei Lin, Nai-Ying Ko, Ying-Ju Chang
Summary: This study demonstrates that using a 0.12% chlorhexidine oral rinse can significantly improve oral health and reduce the occurrence of NV-HAP in hospitalized patients aged 50 and above.
JOURNAL OF NURSING RESEARCH
(2022)
Review
Infectious Diseases
Emilie Dauvergne, Catherine Mullie
Summary: Copper and brass surfaces have been used for their antimicrobial properties to reduce bioburden and bacterial transmission in healthcare settings. The mechanisms of action involve direct contact and release of copper ions, causing oxidative stress and damage to bacteria. While laboratory studies show broad-spectrum activity, further research is needed to assess the long-term effects and impact on hospital-acquired infections.
Article
Public, Environmental & Occupational Health
T. Sevin, C. Daniau, S. Alfandari, E. Piednoir, C. Dumartin, H. Blanchard, L. Simon, A. Berger-Carbonne, S. Le Vu
Summary: This study analyzed antimicrobial prescription patterns for various healthcare-associated infections (HAIs) in France based on 2017 data, highlighting the importance of tailoring treatments to specific pathogens and their resistance profiles. The findings underscore the need for personalized antimicrobial stewardship efforts in combating HAIs.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Critical Care Medicine
Giacomo Grasselli, Vittorio Scaravilli, Davide Mangioni, Luigia Scudeller, Laura Alagna, Michele Bartoletti, Giacomo Bellani, Emanuela Biagioni, Paolo Bonfanti, Nicola Bottino, Irene Coloretti, Salvatore Lucio Cutuli, Gennaro De Pascale, Daniela Ferlicca, Gabriele Fior, Andrea Forastieri, Marco Franzetti, Massimiliano Greco, Amedeo Guzzardella, Sara Linguadoca, Marianna Meschiari, Antonio Messina, Gianpaola Monti, Paola Morelli, Antonio Muscatello, Simone Redaelli, Flavia Stefanini, Tommaso Tonetti, Massimo Antonelli, Maurizio Cecconi, Giuseppe Foti, Roberto Fumagalli, Massimo Girardis, Marco Ranieri, Pierluigi Viale, Mario Raviglione, Antonio Pesenti, Andrea Gori, Alessandra Bandera
Summary: Critically ill patients with COVID-19 are at high risk for hospital-acquired infections (HAIs), especially ventilator-associated pneumonia (VAP) and bloodstream infections (BSIs) caused by multidrug-resistant organisms. HAIs prolong mechanical ventilation and hospitalization, and those complicated by septic shock nearly double mortality rate.
Article
Infectious Diseases
Fabian von Dehn, Nico T. Mutters, Vanessa M. Eichel, Uta Merle, Thorsten Brenner, Michael Nafe, Anja Sander, Martin Wolkewitz, Uwe Frank
Summary: This study investigated the effect of daily whole-body bathing using disposable washcloth wipes/caps impregnated with the antiseptic DDAC. The results showed a reduced incidence of central-venous-line-associated infections caused by Gram-positive bacteria in ICU patients undergoing DDAC bathing. There was also a trend towards reduction in catheter-related bloodstream infections and bloodstream infections. DDAC may be a promising agent for whole-body bathing of ICU patients.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Ghada El-Saeed Mashaly, Mervat El-Sayed Mashaly
Summary: Colistin-heteroresistance among carbapenemase-producing Enterobacter species is a growing serious medical problem, potentially impacting the treatment of these multidrug-resistant pathogens.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Public, Environmental & Occupational Health
Leigh Smith, Sara M. Karaba, Joe Amoah, George Jones, Robin K. Avery, Kathryn Dzintars, Taylor Helsel, Sara E. Cosgrove, Valeria Fabre
Summary: A multicenter cohort study of 963 adults hospitalized due to COVID-19 found that 5% had a proven hospital-acquired infection (HAI) and 21% had a proven, probable, or possible HAI. Risk factors for proven or probable HAIs included intensive care unit admission, dexamethasone use, severe COVID-19, heart failure, and antibiotic exposure upon admission.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Infectious Diseases
Caiyun Chen, Ping Zhu, Yongxiang Zhang, Bo Liu
Summary: This study found that the new prevention and control requirements implemented during the COVID-19 pandemic had significant effects on community-acquired infections (CAIs) but not on hospital-acquired infections (HAIs).
BMC INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Kuei-Lien Tien, Jann-Tay Wang, Wang-Huei Sheng, Hui-Ji Lin, Pao-Yu Chung, Chin-Yuan Tsan, Yi-Hsuan Chen, Chi-Tai Fang, Yee-Chun Chen, Shan-Chwen Chang
Summary: The study found that using Chlorhexidine (CHG) bathing in ICUs can significantly reduce the incidence of VRE-related healthcare-associated infections (HAIs), while standard care showed no effect on the risk of VRE-HAIs.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Review
Multidisciplinary Sciences
Molly Kukua Abban, Eunice Ampadubea Ayerakwa, Lydia Mosi, Abiola Isawumi
Summary: The burden of Hospital care-associated infections (HCAIs) is a growing global concern, especially in Intensive care units (ICUs) housing high-risk and immunocompromised patients. This review discusses the contributions of antimicrobial resistance (AMR) pathogens to the increasing burden of HCAIs, with a focus on last-resort antibiotics such as polymyxins. The review explores the impact of structural modifications and cationic interactions on AMR and severity of HCAIs. Bacterial survival mechanisms and plasmid-mediated resistance are also discussed, highlighting the challenges in mitigating AMR within ICUs.
Article
Microbiology
Hamzah J. J. Aldali, Azra Khan, Abdullah A. A. Alshehri, Jehad A. A. Aldali, Sultan Ayoub Meo, Ali Hindi, Emadeldin M. M. Elsokkary
Summary: Globally, hospital-acquired infections (HAIs) are increasing and causing high mortality and morbidity rates. This study focused on the analysis of carbapenem-resistant E. coli and K. pneumoniae in UK hospitals from 2009 to 2021. The study also examined the best approaches to patient management for controlling the spread of carbapenem-resistant Enterobacteriaceae (CRE).
Article
Public, Environmental & Occupational Health
Molly Steele, Ryan R. Hurtado, Karen Rychlik, Amanda Bonebrake, Maria C. Bovee, Anna O'Donnell, Joshua Perryman, Larry K. Kociolek
Summary: A quasi-experimental study conducted in a pediatric hematology-oncology unit showed that whole-room ultraviolet-C disinfection significantly reduced hospital-onset Clostridioides difficile infection, but did not affect healthcare-associated viral respiratory infections or central line-associated bloodstream infections.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Surgery
Kristy Kummerow Broman, Cameron E. Gaskill, Adil Faqih, Michael Feng, Sharon E. Phillips, William B. Lober, Richard A. Pierce, Michael D. Holzman, Heather L. Evans, Benjamin K. Poulose
Article
Infectious Diseases
John L. Semple, Heather Evans, William Lober, Danielle Lavallee
SURGICAL INFECTIONS
(2019)
Article
Infectious Diseases
William B. Lober, Heather L. Evans
SURGICAL INFECTIONS
(2019)
Article
Infectious Diseases
Ziyu Jiang, Randy Ardywibowo, Aven Samereh, Heather L. Evans, William B. Lober, Xiangyu Chang, Xiaoning Qian, Zhangyang Wang, Shuai Huang
SURGICAL INFECTIONS
(2019)
Article
Infectious Diseases
Aven Samareh, Xiangyu Chang, William B. Lober, Heather L. Evans, Zhangyang Wang, Xiaoning Qian, Shuai Huang
SURGICAL INFECTIONS
(2019)
Article
Infectious Diseases
Sheri Chernetsky Tejedor, Joe Sharma, Danielle C. Lavallee, William B. Lober, Heather L. Evans
SURGICAL INFECTIONS
(2019)
Article
Emergency Medicine
Molly L. Tolins, Daniel S. Hippe, Sophie C. Morse, Heather L. Evans, William B. Lober, Marie C. Vrablik
JOURNAL OF EMERGENCY MEDICINE
(2019)
Review
Infectious Diseases
Vanessa P. Ho, Haytham Kaafarani, Rishi Rattan, Nicholas Namias, Heather Evans, Tanya L. Zakrison
SURGICAL INFECTIONS
(2020)
Editorial Material
Surgery
Chelsea A. Harris, Heather L. Evans, Dana A. Telem
Review
Infectious Diseases
Daithi S. Heffernan, Heather L. Evans, Jared M. Huston, Jeffrey A. Claridge, David P. Blake, Addison K. May, Greg S. Beilman, Philip S. Barie, Lewis J. Kaplan
SURGICAL INFECTIONS
(2020)
Review
Health Care Sciences & Services
Ross J. Lordon, Sean P. Mikles, Laura Kneale, Heather L. Evans, Sean A. Munson, Uba Backonja, William B. Lober
HEALTH INFORMATICS JOURNAL
(2020)
Article
Infectious Diseases
Heather L. Evans, Christopher S. Thomas, L. Hannah Bell, Ashley B. Hink, Stephanie O'Driscoll, Catherine D. Tobin, Cassandra D. Salgado
SURGICAL INFECTIONS
(2020)
Article
Medicine, General & Internal
David R. Flum, Giana H. Davidson, Sarah E. Monsell, Nathan I. Shapiro, Stephen R. Odom, Sabrina E. Sanchez, F. Thurston Drake, Katherine Fischkoff, Jeffrey Johnson, Joe H. Patton, Heather Evans, Joseph Cuschieri, Amber K. Sabbatini, Brett A. Faine, Dionne A. Skeete, Mike K. Liang, Vance Sohn, Karen McGrane, Matthew E. Kutcher, Bruce Chung, Damien W. Carter, Patricia Ayoung-Chee, William Chiang, Amy Rushing, Steven Steinberg, Careen S. Foster, Shaina M. Schaetzel, Thea P. Price, Katherine A. Mandell, Lisa Ferrigno, Matthew Salzberg, Daniel A. DeUgarte, Amy H. Kaji, Gregory J. Moran, Darin Saltzman, Hasan B. Alam, Pauline K. Park, Lillian S. Kao, Callie M. Thompson, Wesley H. Self, Julianna T. Yu, Abigail Wiebusch, Robert J. Winchell, Sunday Clark, Anusha Krishnadasan, Erin Fannon, Danielle C. Lavallee, Bryan A. Comstock, Bonnie Bizzell, Patrick J. Heagerty, Larry G. Kessler, David A. Talan
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Surgery
Miriam Y. Neufeld, Wayne Bauerle, Evert Eriksson, Faris K. Azar, Heather L. Evans, Meredith Johnson, Ryan A. Lawless, Lawrence Lottenberg, Sabrina E. Sanchez, Vlad V. Simianu, Christopher S. Thomas, F. Thurston Drake
Summary: The study found that there was a 29% decrease in mean biweekly appendicitis presentations after the pandemic declaration, with a more significant decrease in uncomplicated cases. However, changes in complicated cases were not significant. This suggests that individual health care-use behaviors may have played a role in the differences observed.
Article
Critical Care Medicine
Melanie Smith Condeni, Alyson T. Basting, Patrick G. Costello, Ashley DePriest, Evert A. Eriksson, Heather Evans, Kristie Hertel, Andre L. Holder, Alyssa N. Kester, Kinsey R. Kowalski, Carolyn Magee Bell, Barbara McLean, Michael Reichert, Melissa Santibanez, Patrick M. Wieruszewski, Andrea Sikora Newsome
Summary: This review summarizes selected meta-analyses and trials related to critical care pharmacotherapy published in 2019, covering areas such as cardiac arrest and delirium, including clinical practice guidelines, meta-analyses, and original research trials.
JOURNAL OF CRITICAL CARE
(2021)