Article
Neurosciences
Jing-Jing Zhou, Jian-Ying Shao, Shao-Rui Chen, De-Pei Li, Hui-Lin Pan
Summary: The study reveals that chronic stress-induced persistent hypertension is mediated by enhanced sympathetic outflow via alpha 2 delta-1-bound NMDARs in the paraventricular nucleus. This provides a cellular and molecular basis for understanding how genetic and environmental factors interact to cause persistent hypertension.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Alexander Nelde, Laura Krumm, Subhi Arafat, Benjamin Hotter, Christian H. Nolte, Jan F. Scheitz, Markus G. Klammer, Michael Kraemer, Franziska Scheib, Matthias Endres, Andreas Meisel, Christian Meisel
Summary: In this study, a machine learning model was developed to predict the risk of stroke patients developing SAP and identify high-risk patients for interventions in clinical practice. The model showed promising results in predicting clinically apparent SAP and outperformed traditional clinical scores.
JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Ognjen Arandjelovic
Summary: This study proposes a sentientist approach to address the ethical challenges in providing care to patients in a persistent vegetative state (PVS). By systematically analyzing and discussing different cases, the study argues that the object of care can shift between the patient, their kin, or the healthcare staff. This is the first comprehensive proposal regarding decision-making processes in the provision of life-sustaining treatment to PVS patients.
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2023)
Article
Biology
Alexey Evtushenko, Vladimir Evtushenko, Anna Gusakova, Tatiana Suslova, Yulia Varlamova, Konstantin Zavadovskiy, Denis Lebedev, Anton Kutikhin, Elena Pavlyukova, Sergey Mamchur
Summary: We investigated the effects of radiofrequency ablation (RFA) on neurohumoral transmitter levels and myocardial I-123-metaiodobenzylguanidine (I-123-MIBG) uptake in patients with acquired valvular heart disease. The decrease in norepinephrine (NE) level in the coronary sinus was directly associated with the heart-to-mediastinum ratio and negatively correlated with I-123-MIBG uptake defects. NE level decreased significantly after surgery in both atrial fibrillation (AF) patients and patients with sinus rhythm. The difference in NE levels between the ascending aorta and coronary sinus (& UDelta;NE) of -400 pg/mL was determined as a cut-off value to evaluate RFA efficacy.
Article
Neurosciences
Xiang Xiao, Wenyi Chen, Xiaoying Zhang
Summary: Music therapy has been used as an alternative treatment for arousing patients with disorders of consciousness in clinical settings. However, the specific impact of music on these patients remains challenging to identify due to the lack of continuous quantitative measurements and a non-musical sound control group in most studies.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Endocrinology & Metabolism
Martha Campbell-Thompson, Shiue-Cheng Tang
Summary: Tissue optical clearing has regained attention recently thanks to advancements in methods, microscopy systems, and 3-D image analysis programs. It is particularly beneficial for studying neuroanatomy, tissue vasculature, and lymphatic systems, offering new opportunities for examining pancreatic and islet functions in health and diabetes through defining their neurovascular anatomy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Rob Sillevis, Gabriel Trincado, Eric Shamus
Summary: This study demonstrates that a 5-minute neuroscience-based pain education video reduced perceived pain in a small sample of subjects with persistent pain. Watching the video did not result in an immediate generalized autonomic nervous system response, but did result in a different reaction in each eye. This supports the idea that the pain experience is determined by the balance between conscious cognitive processes and subconscious processes based on previous psychological experiences.
Article
Medicine, General & Internal
Piergiuseppe Liuzzi, Antonello Grippo, Francesca Draghi, Bahia Hakiki, Claudio Macchi, Francesca Cecchi, Andrea Mannini
Summary: The aim of this study was to derive a proxy of autonomic functions by analyzing the variability of respiratory rates, and compare its diagnostic capability with known neurophysiological biomarkers of consciousness. The results showed that higher complexity of respiratory rates was significantly associated with higher consciousness levels and improved diagnostic models' performances.
Article
Orthopedics
Anders Galaasen Bakken, Andreas Eklund, Anna Warnqvist, Soren O'Neill, David M. Hallman, Iben Axen
Summary: This study investigated the association between changes in pain and heart rate variability in patients with persistent or recurrent neck pain. The results showed that changes in pain after home stretching exercises with or without spinal manipulative therapy over two weeks were not significantly associated with changes in heart rate variability. Future studies should rely on more frequent measurements of heart rate variability during longer treatment periods.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Environmental Sciences
Santiago Navarro-Ledesma, Leo Pruimboom, Enrique Lluch, Lirios Duenas, Silvia Mena-Del Horno, Ana Gonzalez-Munoz
Summary: There is evidence suggesting a correlation between the amount of physical activity, psychological factors, and vegetative symptoms in patients with fibromyalgia. However, further research considering other factors is needed to fully understand this association.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Yan Huang, Feng-Ming Xiao, Wen-Jie Tang, Jing Qiao, Hai-Feng Wei, Yuan-Yun Xie, You-Zhen Wei
Summary: This study reports a case of an 11-year-old boy with persistent vegetative state (PVS), and observed significant improvements in the patient's recovery after high-concentration hydrogen gas inhalation treatment. This provides a new approach and potential for the treatment of PVS.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Psychiatry
Peter Joe, Jose C. Clemente, Enrica Piras, David S. Wallach, Jessica Robinson -Papp, Emeka Boka, Brooke Remsen, Mharisi Bonner, David Kimhy, Deborah Goetz, Kevin Hoffman, Jakleen Lee, Eugene Ruby, Sarah Fendrich, Oded Gonen, Dolores Malaspina
Summary: The mechanism of psychosis might involve hippocampal inflammation, which could be linked to the microbiome-gut-brain-axis (MGBS). A study is conducted to test this hypothesis, using research diagnostic interviews and symptom assessments to categorize subjects into three groups. Preliminary data shows that C-section birth is associated with higher GLX concentrations in psychotic cases, worse symptoms in affective disorder cases, and smaller hippocampal volume in controls.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Immunology
Katherine A. Mifflin, Faith H. Brennan, Zhen Guan, Kristina A. Kigerl, Angela R. Filous, Xiaokui Mo, Jan M. Schwab, Phillip G. Popovich
Summary: Pulmonary infection is a common and serious complication after spinal cord injury (SCI). This study shows that SCI not only impairs the immune system in the lung, but also decreases the tissue-specific defense mechanisms against infection. Moreover, the current drug AMD3100 is only partially effective in overcoming this immune suppression. Novel strategies are needed to prevent lung infection after SCI.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Takashi Kusayama, Juyi Wan, Yuan Yuan, Xiao Liu, Xiaochun Li, Changyu Shen, Michael C. Fishbein, Thomas H. Everett, Peng-Sheng Chen
Summary: This study conducted a comparative study of high-output and low-output ScNS in a canine model, finding that high-output ScNS significantly reduced ventricular rate and stellate ganglion nerve activity, improved left ventricular ejection fraction, reduced atrial fibrosis, while low-output ScNS had no significant effects.
Article
Clinical Neurology
Mario Habek, Fabian Leys, Magdalena Krbot Skoric, Diogo Reis Carneiro, Giovanna Calandra-Buonaura, Jennifer Camaradou, Giacomo Chiaro, Pietro Cortelli, Cristian Falup-Pecurariu, Roberta Granata, Pietro Guaraldi, Raimund Helbok, Max J. Hilz, Valeria Iodice, Jens Jordan, Evert C. A. Kaal, Anita Kamondi, Anne Pavy Le Traon, Isabel Rocha, Johann Sellner, Jean Michel Senard, Astrid Terkelsen, Gregor K. Wenning, Thomas Berger, Roland D. Thijs, Walter Struhal, Alessandra Fanciulli
Summary: This study investigated neurology-driven or interdisciplinary clinical laboratories for autonomic nervous system disorders in Europe and found disparities in healthcare services availability among countries. There is a need for improved access to specialized care, particularly in South, East, and Greater Europe.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Critical Care Medicine
Joan Machamer, Nancy Temkin, Sureyya Dikmen, Lindsay D. Nelson, Jason Barber, Phillip Hwang, Kim Boase, Murray B. Stein, Xiaoying Sun, Joseph Giacino, Michael A. McCrea, Sabrina R. Taylor, Sonia Jain, Geoff Manley
Summary: Symptom endorsement is common after traumatic brain injury (TBI), especially in mild cases. The prevalence of persistent symptoms has been debated. This study found that persistent symptoms are common at least a year after TBI, and TBI participants have a higher symptom burden compared to other groups.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Critical Care Medicine
David A. Zuckerman, Joseph T. Giacino, Yelena G. Bodien
Summary: The outcomes of TBI are diverse and not standardized, with dichotomization of outcomes into favorable and unfavorable categories potentially limiting detection of treatment effects and impacting decision-making processes.
JOURNAL OF NEUROTRAUMA
(2022)
Letter
Rehabilitation
John Whyte, Jarrad Van Stan, Lyn Turkstra
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Critical Care Medicine
Jennifer A. Weaver, Alison M. Cogan, Katherine A. O'Brien, Piper Hansen, Joseph T. Giacino, John Whyte, Theresa Bender Pape, Philip van der Wees, Trudy Mallinson
Summary: This study evaluated the hierarchical structure of the Coma Recovery Scale-Revised (CRS-R) rating scale categories and their alignment with the Aspen consensus criteria for determining disorders of consciousness (DoC). The study found that most of the rating scale categories were aligned with the consensus criteria, but there were a few deviations. The study also found a strong correlation between the individual measures and states of consciousness. The findings provide empirical evidence for revising the diagnostic criteria for certain states of consciousness.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Critical Care Medicine
Eva M. Palacios, Esther L. Yuh, Christine L. Mac Donald, Ioanna Bourla, Jamie Wren-Jarvis, Xiaoying Sun, Mary J. Vassar, Ramon Diaz-Arrastia, Joseph T. Giacino, David O. Okonkwo, Claudia S. Robertson, Murray B. Stein, Nancy Temkin, Michael A. McCrea, Harvey S. Levin, Amy J. Markowitz, Sonia Jain, Geoffrey T. Manley, Pratik Mukherjee
Summary: This multi-center study aimed to investigate the acute effects of mild traumatic brain injury (mTBI) on white matter (WM) microstructure and its prognostic significance. The results showed that there were changes in WM microstructure at two weeks and six months post-injury, which were associated with long-term outcome. Diffusion tensor imaging (DTI) provides reliable imaging biomarkers for assessing dynamic WM microstructural changes after mTBI, which could be useful for patient selection and treatment response evaluation in clinical trials.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Clinical Neurology
David Fischer, Brian L. Edlow, Joseph T. Giacino, David M. Greer
Summary: This article presents a stepwise conceptual framework for neuroprognostication after severe brain injury, aiming to provide structure and guidance to supplement clinical judgement and direct future investigation.
NATURE REVIEWS NEUROLOGY
(2022)
Article
Critical Care Medicine
Shraddha Mainali, Venkatesh Aiyagari, Sheila Alexander, Yelena Bodien, Varina Boerwinkle, Melanie Boly, Emery Brown, Jeremy Brown, Jan Claassen, Brian L. Edlow, Erika L. Fink, Joseph J. Fins, Brandon Foreman, Jennifer Frontera, Romergryko G. Geocadin, Joseph Giacino, Emily J. Gilmore, Olivia Gosseries, Flora Hammond, Raimund Helbok, J. Claude Hemphill, Karen Hirsch, Keri Kim, Steven Laureys, Ariane Lewis, Geoffrey Ling, Sarah L. Livesay, Victoria McCredie, Molly McNett, David Menon, Erika Molteni, DaiWai Olson, Kristine O'Phelan, Soojin Park, Len Polizzotto, Jose Javier Provencio, Louis Puybasset, Chethan P. Venkatasubba Rao, Courtney Robertson, Benjamin Rohaut, Michael Rubin, Tarek Sharshar, Lori Shutter, Gisele Sampaio Silva, Wade Smith, Robert D. Stevens, Aurore Thibaut, Paul Vespa, Amy K. Wagner, Wendy C. Ziai, Elizabeth Zink, Jose Suarez
Summary: This article summarizes the background, research priorities, panel discussions, and deliverables of the 2nd Curing Coma National Institutes of Health (NIH) symposium. The symposium focused on six major domains related to disorders of consciousness and identified actionable items for the Curing Coma Campaign mission through interactive and inspiring presentations and panel discussions.
NEUROCRITICAL CARE
(2022)
Editorial Material
Clinical Neurology
Melissa Shuman Paretsky, Steven Albert, Joseph T. Giacino
Summary: These studies demonstrate international variability in treatment and conflicts in decision-making regarding patients with disorders of consciousness, involving conflicts between physicians, family members, and patients, as well as variation between treatment centers.
Article
Computer Science, Information Systems
Alan D. Kaplan, Qi Cheng, K. Aditya Mohan, Lindsay D. Nelson, Sonia Jain, Harvey Levin, Abel Torres-Espin, Austin Chou, J. Russell Huie, Adam R. Ferguson, Michael McCrea, Joseph Giacino, Shivshankar Sundaram, Amy J. Markowitz, Geoffrey T. Manley
Summary: In this study, a method for modeling heterogeneous data types relevant to TBI was developed to depict the nuanced differences in TBI patients' recovery. The model was trained on various data types and used to infer outcomes based on input data. Additionally, the performance of a likelihood scoring technique for evaluating the risk of prognosis extrapolation was quantified.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Behavioral Sciences
William H. Curley, Yelena G. Bodien, David W. Zhou, Mary M. Conte, Andrea S. Foulkes, Joseph T. Giacino, Jonathan D. Victor, Nicholas D. Schiff, Brian L. Edlow
Summary: This study demonstrates the use of the ABCD framework to assess EEG dynamics and track changes in thalamocortical network function in patients with acute severe traumatic brain injury. The findings suggest that ABCD classifications can provide valuable information for monitoring recovery and predicting outcomes.
Article
Critical Care Medicine
Nancy Temkin, Joan Machamer, Sureyya Dikmen, Lindsay D. Nelson, Jason Barber, Phillip H. Hwang, Kim Boase, Murray B. Stein, Xiaoying Sun, Joseph Giacino, Michael A. McCrea, Sabrina R. Taylor, Sonia Jain, Geoff Manley, RACK-TBI Investigators
Summary: Factors such as TBI-related and post-traumatic stress symptom levels at 2 weeks have large effect sizes when predicting 3-month symptom burden, allowing for more efficient clinical trials by enriching the included sample with individuals reporting a high early symptom burden.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Biochemistry & Molecular Biology
Victor M. Castro, Jonathan Rosand, Joseph T. Giacino, Thomas H. McCoy, Roy H. Perlis
Summary: Neuropsychiatric symptoms may persist following acute COVID-19 illness, but they are not specific to COVID-19 and occur at similar rates among individuals hospitalized for other indications.
MOLECULAR PSYCHIATRY
(2022)
Correction
Critical Care Medicine
Shraddha Mainali, Venkatesh Aiyagari, Sheila Alexander, Yelena Bodien, Varina Boerwinkle, Melanie Boly, Emery Brown, Jeremy Brown, Jan Claassen, Brian L. Edlow, Ericka L. Fink, Joseph J. Fins, Brandon Foreman, Jennifer Frontera, Romergryko G. Geocadin, Joseph Giacino, Emily J. Gilmore, Olivia Gosseries, Flora Hammond, Raimund Helbok, J. Claude Hemphill, Karen Hirsch, Keri Kim, Steven Laureys, Ariane Lewis, Geoffrey Ling, Sarah L. Livesay, Victoria McCredie, Molly McNett, David Menon, Erika Molteni, DaiWai Olson, Kristine O'Phelan, Soojin Park, Len Polizzotto, Jose Javier Provencio, Louis Puybasset, Chethan P. Venkatasubba Rao, Courtney Robertson, Benjamin Rohaut, Michael Rubin, Tarek Sharshar, Lori Shutter, Gisele Sampaio Silva, Wade Smith, Robert D. Stevens, Aurore Thibaut, Paul Vespa, Amy K. Wagner, Wendy C. Ziai, Elizabeth Zink, Jose I. Suarez
NEUROCRITICAL CARE
(2022)
Article
Neurosciences
Jacqueline R. Kulbe, Sonia Jain, Lindsay D. Nelson, Frederick K. Korley, Pratik Mukherjee, Xiaoying Sun, David O. Okonkwo, Joseph T. Giacino, Mary J. Vassar, Claudia S. Robertson, Michael A. McCrea, Kevin K. W. Wang, Nancy Temkin, Christine L. Mac Donald, Sabrina R. Taylor, Adam R. Ferguson, Amy J. Markowitz, Ramon Diaz-Arrastia, Geoffrey T. Manley, Murray B. Stein, Ann-Christine Duhaime, V. Ramana Feeser, C. Dirk Keene, Christopher Madden, Randall Merchant, Ava Puccio, David Schnyer, Sabrina R. Taylor, Alex Valadka, John K. Yue, Esther L. Yuh, Ross Zafonte
Summary: This study aimed to determine whether two day-of-injury blood-based biomarkers are predictive of posttraumatic stress disorder (PTSD). The results showed that elevated day-of-injury serum GFAP levels are associated with a reduced risk of PTSD after mild TBI.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Shawn R. Eagle, Ava M. Puccio, Lindsay D. Nelson, Michael McCrea, Joseph Giacino, Ramon Diaz-Arrastia, William Conkright, Sonia Jain, Xiaoying Sun, Geoffrey Manley, David O. Okonkwo
Summary: Obesity is associated with higher symptomatology and blood inflammatory markers in recovery following mTBI. The study found that obese patients had higher concentrations of hsCRP and IL-6 at multiple time points after injury, as well as higher RPQ scores at 6 and 12 months.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)