Article
Neurosciences
Jadwiga N. Bilchak, Kyle Yeakle, Guillaume Caron, Dillon Malloy, Marie-Pascale Cote
Summary: Increasing KCC2 activity to restore chloride homeostasis and endogenous inhibition is an effective approach to reduce spastic symptoms in individuals with SCI, potentially avoiding severe side effects and improving quality of life.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Timothy D. Faw, Bimal Lakhani, Petra Schmalbrock, Michael V. Knopp, Keith R. Lohse, John L. K. Kramer, Hanwen Liu, Huyen T. Nguyen, Eileen G. Phillips, Anna Bratasz, Lesley C. Fisher, Rochelle J. Deibert, Lara A. Boyd, Dana M. McTigue, D. Michele Basso
Summary: Experience-dependent white matter plasticity offers new potential for rehabilitation-induced recovery after neurotrauma. Downhill training increases myelin water fraction in brain motor learning regions and mixed motor and sensory tracts of the ventral cervical spinal cord in humans, and induces oligodendrogenesis and improves sensorimotor recovery in mice with thoracic SCI.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Engineering, Biomedical
Sarah E. Mondello, Lisa Young, Viet Dang, Amanda E. Fischedick, Nicholas M. Tolley, Tian Wang, Madison A. Bravo, Dalton Lee, Belinda Tucker, Megan Knoernschild, Benjamin D. Pedigo, Philip J. Horner, Chet T. Moritz
Summary: This study aims to develop a mechanistic understanding of how to promote functional recovery following spinal cord injury. The use of optogenetic stimulation shows promising results in promoting recovery of skilled limb movements and axonal growth. This finding suggests that optogenetic stimulation could be a potential therapy for spinal cord injury.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Medicine, General & Internal
Lucie Bourguignon, Bobo Tong, Fred Geisler, Martin Schubert, Frank Rohrich, Marion Saur, Norbert Weidner, Rudiger Rupp, Yorck-Bernhard B. Kalke, Rainer Abel, Doris Maier, Lukas Grassner, Harvinder S. Chhabra, Thomas Liebscher, Jacquelyn J. Cragg, John Kramer, Armin Curt, Catherine R. Jutzeler
Summary: Despite changes in the epidemiological characteristics of traumatic spinal cord injury, neurological and functional recovery has remained stable over the last two decades. This study provides an important resource for informing clinical practice and implementing new clinical trials.
Article
Medicine, General & Internal
Niraj Singh Tharu, Timothy Tin-Yan Lee, Kelly Ka-Lee Lai, Ting-Er Lau, Chui-Yi Chan, Yong-Ping Zheng
Summary: The aim of this study was to compare the sagittal spinal alignment between individuals with chronic SCI and normal subjects, and to determine the effects of TSCS on thoracic kyphosis and lumbar lordosis to restore normal spinal alignment. A case series study was conducted, involving 12 individuals with SCI and 10 neurologically intact subjects. The results showed that individuals with SCI had a higher risk of spinal deformity, but TSCS treatment was able to reverse this by reducing the thoracic kyphosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rehabilitation
Elizabeth R. Felix, Diana D. Cardenas, Thomas N. Bryce, Susan Charlifue, Tae Kyong Lee, Bria MacIntyre, Sara Mulroy, Heather Taylor
Summary: This study compared the prevalence, intensity ratings, and interference ratings of neuropathic pain and nociceptive pain in chronic spinal cord injury patients, finding significant differences in intensity and interference levels between neuropathic pain and non-neuropathic pain. Additionally, women and paraplegic patients were found to have a higher prevalence of neuropathic pain, providing important insights for treatment strategies.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Medicine, General & Internal
Md Akhlasur Rahman, Niraj Singh Tharu, Sylvia M. Gustin, Yong-Ping Zheng, Monzurul Alam
Summary: Spinal cord injury (SCI) is a debilitating injury with severe complications, but recent development of noninvasive electrical neuromodulation treatments offers hope for rehabilitation. Trans-spinal direct current stimulation (tsDCS) and trans-spinal pulsed current stimulation (tsPCS) have shown promising results in improving sensorimotor and autonomic functions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Sen Lin, Chang Xu, Xuechen Yin, He Tian, Xifan Mei
Summary: Spinal cord injury (SCI) causes chronic functional impairment in patients, especially older adults who often have shorter lifespans. Overexpression of p75 leads to neuroinflammation and motor dysfunction following SCI in adult mice. In this study, it was found that p75 deletion could promote motor/sensory function recovery and improve survival in both adult and aged mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hatice Kumru, Loreto Garcia-Alen, Aina Ros-Alsina, Sergiu Albu, Margarita Valles, Joan Vidal
Summary: This study aimed to investigate whether transcutaneous spinal cord stimulation (tSCS) could improve respiratory function in individuals with cervical spinal cord injury (cSCI). The results showed that subjects who received tSCS combined with inspiratory muscle training (IMT) experienced significant improvements in breathlessness/dyspnea, hypophonia, maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), and forced vital capacity. Therefore, tSCS may serve as an effective adjunctive therapy for respiratory impairments following SCI.
Article
Rehabilitation
Elham Mahmoudi, Paul Lin, Mark D. Peterson, Michelle A. Meade, Denise G. Tate, Neil Kamdar
Summary: Middle-aged and older adults with traumatic spinal cord injury (TSCI) have a higher risk of developing Alzheimer disease and related dementia (ADRD). Improved clinical screening and early interventions to preserve cognitive function are crucial for this patient population.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Rehabilitation
Cristina Shea, Chloe Slocum, Richard Goldstein, Mary Joan Roach, Russell Griffin, Yuying Chen, Ross Zafonte
Summary: This study aimed to investigate whether initial emergency department physiological measures and trauma severity predict functional outcomes and neurologic recovery in traumatic spinal cord injury. The results showed that emergency department physiological parameters did not predict functional outcomes in this cohort.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Review
Pediatrics
Natalia S. C. Cunha, Anahita Malvea, Sarah Sadat, George M. Ibrahim, Michael G. Fehlings
Summary: This review provides a concise overview of key aspects related to spinal cord injuries (SCIs) in children. It covers the etiology, epidemiology, unique challenges, clinical presentation, diagnostic methods, multidisciplinary management, emerging research, and innovative therapies of pediatric SCIs. The need for continued advancements in understanding and treating SCIs in children to improve their functional independence and overall quality of life is emphasized.
Article
Immunology
Emma Schmidt, Pamela Raposo, Romana Vavrek, Karim Fouad
Summary: Inflammation can enhance neuronal sprouting and recovery in rats following spinal cord injury, and systemic lipopolysaccharide treatment in the subacute stage can improve the recovery of the ipsilesional forelimb.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Neurosciences
Margo Randelman, Lyandysha V. Zholudeva, Stephane Vinit, Michael A. Lane
Summary: This article reviews the anatomical incompleteness and neuroplasticity resulting from spinal cord injuries, as well as how non-invasive respiratory treatments can enhance recovery. It focuses on current clinically used respiratory training strategies and those in development, while also considering the impact of training on non-respiratory networks. Insights are given on advances in pre-clinical and translational research in this area, with a look into future directions for enhancing plasticity and improving functional outcomes after SCI.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Engineering, Biomedical
Emi A. Kiyotake, Michael D. Martin, Michael S. Detamore
Summary: This review discusses the potential of regenerative medicine and rehabilitation approaches for SCI, as well as the role of conductive biomaterials in synergizing these two fields. Current limitations and translational challenges for conductive biomaterials in becoming therapeutics for SCI are identified.
ACTA BIOMATERIALIA
(2022)
Article
Rehabilitation
Sherri L. LaVela, Elizabeth Burkhart, Kayla Jones, Christine Pellegrini
Summary: The study found that HCPs generally believe that overweight and obesity are significant issues for individuals with SCI, but they are not aware of published and easily accessible evidence-based guidelines for WM specifically for SCI populations. This suggests the need for more education and proactive efforts to improve awareness among interprofessional HCPs.
Article
Public, Environmental & Occupational Health
Katie J. Suda, Alfredo Traversa, Ursula Patel, Linda Poggensee, Margaret A. Fitzpatrick, Geneva M. Wilson, Charlesnika T. Evans
Summary: This study assessed the treatment trends for patients with CRE from 2012 to 2018. The findings revealed a decrease in the utilization of aminoglycosides and colistin, while there was an increase in the use of extended-spectrum cephalosporins and ceftazidime-avibactam. Moreover, significant uptake of ceftazidime-avibactam, a newly approved antibiotic, was observed for treating CRE infections.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Geneva M. Wilson, Charlesnika T. Evans, Margaret A. Fitzpatrick, Linda Poggensee, Gretchen Gibson, M. Marianne Jurasic, Kelly Echevarria, Katie J. Suda
Summary: A study found that a small proportion of US veterans developed CDI after receiving dental antibiotic prescription, and 80% of them did not receive guideline-recommended antibiotics. Half of these patients had underlying chronic gastrointestinal illnesses, which exacerbated their risk of CDI. More efforts are needed to improve antibiotic stewardship.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Anesthesiology
Tumader Khouja, Jifang Zhou, Walid F. Gellad, Kannop Mitsantisuk, Colin C. Hubbard, Connie H. Yan, Lisa K. Sharp, Gregory S. Calip, Charlesnika T. Evans, Katie J. Suda
Summary: This study evaluates the adverse outcomes and persistent opioid use (POU) after opioid prescriptions by dentists, based on whether opioids were overprescribed or within recommendations. The findings demonstrate that dental prescribing of opioids was associated with adverse outcomes and POU, even when prescriptions were concordant with guidelines. Additional efforts are required to improve analgesic prescribing in dentistry, especially in groups at high risk of opioid-related adverse outcomes.
Article
Public, Environmental & Occupational Health
Connie H. Yan, Todd A. Lee, Lisa K. Sharp, Colin C. Hubbard, Charlesnika T. Evans, Gregory S. Calip, Susan A. Rowan, Jessina C. McGregor, Walid F. Gellad, Katie J. Suda
Summary: The study found that the prescribing rates of opioid medications by dentists in the United States have declined over the past few years, following national trends and the implementation of strategies to regulate opioid prescribing.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Psychology, Clinical
Sherri L. LaVela, Ibuola Kale, Elizabeth Burkhart, Charles H. Bombardier
Summary: This article qualitatively explores strategies to help individuals with spinal cord injuries (SCI) deal with grief and loss. Health care providers offer insights on relational and task-oriented strategies that can reduce suffering and promote healing. Regular screening, coordinated care, support services, and patient education are recommended. Overall, the findings provide guidance for health care providers in addressing grief and loss among individuals with SCI.
REHABILITATION PSYCHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ashley M. Hughes, Erica Lin, Raza A. Hussain, Gretchen Gibson, Marianne Jurasic, Lisa K. Sharp, Colin C. Hubbard, Linda E. Poggensee, Charlesnika T. Evans, Jessina C. McGregor, Walid F. Gellad, Katie J. Suda
Summary: Opioids are frequently prescribed in outpatient dental settings, leading to opportunities for opioid stewardship. This pilot study tested the feasibility of an academic detailing intervention to promote appropriate prescribing of opioids. The results showed high feasibility, indications of adoption of intervention techniques, and a decrease in opioid prescribing rates. It is recommended to collaborate closely with frontline providers to gather feedback and support before scaling and implementing the intervention.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Sherri L. LaVela, Christine Pellegrini, Allen W. Heinemann, Linda S. Ehrlich-Jones, Brian Bartle, Lisa Burkhart, Jessica Pederson
Summary: This article describes the development of an educational curriculum for healthcare providers to help individuals with SCI prevent or manage overweight/obesity. Thematic analysis of interviews conducted with individuals with SCI pinpointed central educational curriculum topics.
DISABILITY AND HEALTH JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
C. H. Yan, C. C. Hubbard, T. A. Lee, L. K. Sharp, C. T. Evans, G. S. Calip, S. A. Rowan, J. C. McGregor, W. F. Gellad, K. J. Suda
Summary: The study evaluated the impact of hydrocodone rescheduling on dental prescribing of opioids in the United States. The findings showed a decrease in hydrocodone prescribing and an increase in non-hydrocodone opioid prescribing by dentists.
JDR CLINICAL & TRANSLATIONAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Katherine Callaway Kim, Tumader Khouja, Jacqueline M. M. Burgette, Charlesnika T. T. Evans, Gregory S. S. Calip, Walid F. F. Gellad, Katie J. J. Suda
Summary: Using join-point regression analysis, we found a decrease in fills for high-alert medicines to children by general dentists from 2012 to 2019. However, older teenagers and children in some areas continue to receive dental opioids at high rates. Future efforts should address non-evidence-based pain management in these groups.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Psychology, Clinical
Sherri L. LaVela, Justina Wu, Andrea L. Nevedal, Alex H. S. Harris, Susan M. Frayne, Katherine D. Arnow, Nicolas B. Barreto, Kristen Davis, Dan Eisenberg
Summary: This article uses qualitative interviews and thematic analysis to explore the impact of the COVID-19 pandemic from the perspective of individuals with spinal cord injuries (SCI). The study found that individuals with SCI faced challenges in receiving healthcare, engaging in healthy lifestyle behaviors, and participating in social activities, which may have negative effects on chronic disease, social health, and emotional well-being.
REHABILITATION PSYCHOLOGY
(2023)
Letter
Public, Environmental & Occupational Health
Tyler D. D. Stone, Cerina Lee, Jacqueline Bannon, Thanh-Huyen T. Vu, Lisa R. R. Hirschhorn, John T. T. Wilkins, Charlesnika T. T. Evans
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Pooja A. Solanki, Colin C. Hubbard, Linda Poggensee, Charlesnika T. Evans, Katie J. Suda
Summary: This study analyzed the downstream outcomes of opioids prescribed by dentists to Veterans within the Veterans Health Administration. It found that opioid-related adverse events were rare in Veterans and lower than other reports. Thus, prescribing opioid alternatives may be an effective strategy to decrease opioid-related poisoning and mortality.
JOURNAL OF PUBLIC HEALTH DENTISTRY
(2023)
Review
Nursing
Tina Stone, Alison Short
Summary: Music therapy has shown some efficacy as a cognitive remediation method for adults with schizophrenia, improving attention, executive function, language, memory, and processing speed. However, further research is needed to better understand and develop cognitively beneficial music therapy programs for this population.
ISSUES IN MENTAL HEALTH NURSING
(2023)
Article
Clinical Neurology
Sarah May, Annette Walder, Casey Hines-Munson, Ivy Poon, S. Ann Holmes, Charlesnika T. Evans, Barbara W. Trautner, Felicia Skelton
Summary: The annual evaluation of SCI/D patients in the Veterans Health Administration often involves urine testing and subsequent antibiotic use, which may be an important focus for antibiotic stewardship programs.
