Article
Rehabilitation
Bertrand Glize, Amandine Cook, Antoine Benard, Sharmila Sagnier, Stephane Olindo, Mathilde Poli, Sabrina Debruxelles, Pauline Renou, Francois Rouanet, Clement Bader, Patrick Dehail, Igor Sibon
Summary: This study aimed to evaluate if a specific positioning of the shoulder could reduce the intensity of post-stroke shoulder pain. The results showed that there was no significant difference in shoulder pain intensity between the group with specific positioning and the group with usual practice.
CLINICAL REHABILITATION
(2022)
Article
Rheumatology
Pernille Steen Pettersen, Tuhina Neogi, Karin Magnusson, Alexander Mathiessen, Hilde Berner Hammer, Till Uhlig, Tore K. Kvien, Ida K. Haugen
Summary: The pathologies and symptom duration of hand osteoarthritis (OA) are related to central sensitization, with erosive hand OA potentially causing greater central sensitization. Structural and inflammatory severity are not associated with central sensitization, while symptom duration does not contribute to central sensitization.
Review
Biochemistry & Molecular Biology
Martina Ferrillo, Amerigo Giudice, Nicola Marotta, Francesco Fortunato, Daniela Di Venere, Antonio Ammendolia, Pietro Fiore, Alessandro de Sire
Summary: Temporomandibular disorders (TMD) are musculoskeletal diseases affecting the jaw muscles and temporomandibular joints. Chronic TMD can be considered as a condition with chronic primary orofacial pain. The main objectives of treatment are to decrease pain, improve jaw joint function, and reduce muscle spasms and pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ryosuke Iio, Tomoya Manaka, Katsumasa Nakazawa, Yoshihiro Hirakawa, Yoichi Ito, Ayako Ogura, Hiroaki Nakamura
Summary: This study aimed to determine the effects of shoulder osteoarthritis and rotator cuff tears (RCT) on central sensitization (CS) and associated factors. The study found that patients with glenohumeral osteoarthritis (GHOA) had significantly higher CS scores and prevalence than patients with RCT without GHOA. Female sex, severe pain, and long pain duration were associated with higher CS scores.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Merce Balasch-Bernat, Lirios Duenas, Marta Aguilar-Rodriguez, Deborah Falla, Alessandro Schneebeli, Marta Navarro-Bosch, Enrique Lluch, Marco Barbero
Summary: This cross-sectional study aimed to investigate the spatial extent of pain and its association with clinical symptoms, psychological features, and pain sensitization in people with frozen shoulder. The results showed that pain predominantly occurred in the anterolateral shoulder region and was positively correlated with pain intensity, pain catastrophizing, and pain sensitization levels.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Jie Zhan, Ying Luo, Wenjin Mao, Leying Zhu, Fanfeng Xu, Yuan Wang, Hongxia Chen, Lechang Zhan
Summary: This study aimed to assess the efficacy of acupuncture versus rehabilitation therapy (RT) for post-stroke shoulder pain (PSSP). The results showed that acupuncture and RT have similar efficacy in relieving shoulder pain, improving upper limb motor function, and activities of daily living (ADL) in patients with PSSP. Both acupuncture and RT may be considered as optimal treatments for PSSP. Further well-designed randomized controlled trials are needed in the future to validate these findings.
Review
Chemistry, Analytical
Rossana Gnasso, Stefano Palermi, Antonio Picone, Domiziano Tarantino, Giampiero Fusco, Maria Michelina Messina, Felice Sirico
Summary: This study systematically reviewed the current literature to determine the effectiveness of robotic-assisted rehabilitation in addressing post-stroke shoulder pain (PSSP) in stroke patients. The reviewed studies indicated a potential benefit of robotic-assisted rehabilitation in reducing PSSP, as well as improvements in the range of motion and overall motor function. However, the results varied across studies due to different protocols and robotic equipment used.
Article
Clinical Neurology
I Aprile, M. Germanotta, A. Cruciani, C. Pecchioli, S. Loreti, D. Papadopoulou, A. Montesano, S. Galeri, M. Diverio, C. Falsini, G. Speranza, E. Langone, M. C. Carrozza, F. Cecchi
Summary: The study investigated the prevalence of poststroke shoulder pain and its relationship with the neuropathic component, as well as its impact on upper limb motor function, strength, disability, and quality of life. Results showed that shoulder pain can negatively affect motor performance and quality of life, but can be reduced after rehabilitation treatment.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Review
Medicine, General & Internal
Gentian Vyshka
Summary: Painful conditions are common reasons for seeking medical advice, but clinicians often separate them from mental disorders and downplay their importance. However, the presence of pain has been extensively studied and the coexistence of pain and mental health issues is a reality that needs explanation.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Health Care Sciences & Services
Paraskevi Bilika, Jo Nijs, Emmanouil Fandridis, Zacharias Dimitriadis, Nikolaos Strimpakos, Eleni Kapreli
Summary: This study examined the associations between central sensitization and various factors in patients with chronic shoulder pain. The results showed that catastrophizing, depression, and functionality were predictive factors for central sensitization symptoms. Patients classified as centrally sensitized had worse functionality, psychological factors, and pain intensity.
Article
Medicine, General & Internal
Rosalinda Romero-Godoy, Sara Raquel Romero-Godoy, Manuel Romero-Acebal, Mario Gutierrez-Bedmar
Summary: This study aimed to evaluate the electrophysiological responses in patients with chronic tension-type headache (CTTH) and correlate them with psychopathological manifestations. The results showed that CTTH patients have reduced ability to recognize non-nociceptive sensory stimuli, increased pain facilitation, and poor central pain control. This is linked to hypoexcitability of A beta nerve fibers and is directly associated with psychological comorbidity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Orthopedics
Tiziano Innocenti, Diego Ristori, Patrizia Galantini, Marco Testa, Mauro Di Bari
Summary: This study systematically reviewed the impact of altered central pain modulation on post-surgical outcomes in patients undergoing shoulder surgery for musculoskeletal disorders. It found that fear avoidance beliefs and inadequate coping strategies were significantly correlated with worse pain and function scores. Surgeons and physical therapists should be aware of these factors in preoperative assessment to potentially improve outcomes for these patients.
ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
(2021)
Article
Clinical Neurology
Yaomei Li, Siqi Yang, Lijun Cui, Yong Bao, Lin Gu, Huijuan Pan, Jixian Wang, Qing Xie
Summary: Hemiplegic shoulder pain is a common complication after stroke, which hinders the rehabilitation of upper extremity motor function. This study observed the prevalence of post-stroke shoulder pain in the middle-aged and elderly population, identified the risk factors, and explored its effect on stroke outcome. Shoulder pain was more likely to occur in women, patients with large-area stroke, increased tension of biceps or triceps, subluxation, and limited range of motion. Patients with shoulder pain had significantly lower ability in daily living than those without shoulder pain.
FRONTIERS IN NEUROLOGY
(2023)
Review
Anesthesiology
Davide Previtali, Vittorio Bordoni, Giuseppe Filardo, Paolo Marchettini, Enrico Guerra, Christian Candrian
Summary: Pain sensitization is common in patients with shoulder pain and may lead to poorer treatment outcomes. While there was no difference in pressure pain threshold and central pain modulation between patients with shoulder pain and asymptomatic controls, a significant increase was documented in suprathreshold heat pain response.
CLINICAL JOURNAL OF PAIN
(2021)
Article
Clinical Neurology
Calogero Malfitano, Angela Rossetti, Stefano Scarano, Chiara Malloggi, Luigi Tesio
Summary: In this study, a patient with thalamic stroke and pain symptoms showed improvement in pain and paresthesia after receiving rTMS treatment. The recovery in motor cortex excitability of the affected hemisphere was associated with the clinical improvement in this central post-stroke pain case.
FRONTIERS IN NEUROLOGY
(2021)
Review
Oncology
Jianrong Zhang, Maarten J. IJzerman, Jasmeen Oberoi, Napin Karnchanachari, Rebecca J. Bergin, Fanny Franchini, Paige Druce, Xiaofei Wang, Jon D. Emery
Summary: This comprehensive overview examines the diagnosis and treatment times for lung cancer patients, the impact of time intervals on patient outcomes, risk factors, interventions to reduce time intervals, and methodological issues in related studies. The findings suggest that there are significant variations in diagnosis and treatment times, which often exceed the recommended guidelines. The association between time intervals and patient outcomes is inconsistent. Identified risk factors and effective interventions highlight the potential for improvement in addressing diagnostic and treatment delays.
Article
Pediatrics
Luiza R. Grazziotin, Gillian Currie, Marinka Twilt, Maarten J. Ijzerman, Michelle M. A. Kip, Hendrik Koffijberg, Susanne M. Benseler, Joost F. Swart, Sebastiaan J. Vastert, Nico M. Wulffraat, Rae S. M. Yeung, Deborah A. Marshall
Summary: This study evaluated prescription patterns of conventional and biologic disease modifying anti-rheumatic drugs (c-DMARDs and b-DMARDs) for children with juvenile idiopathic arthritis (JIA). The study found that within the first year of rheumatology care, 62% of patients were prescribed a c-DMARD and 21% were prescribed a b-DMARD. There were significant differences in prescription patterns among different subtypes of JIA, and many patients required multiple treatment lines.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Oncology
Victoria M. White, Karolina Lisy, Andrew Ward, Eli Ristevski, Melanie Clode, Kate Webber, Jon Emery, Maarten J. Ijzerman, Nina Afshar, Jeremy Millar, Peter Gibbs, Sue Evans, Michael Jefford
Summary: The study explored the impact of socio-demographic factors, comorbidities, and information needs on the quality of life outcomes of cancer survivors. Findings showed that age, socio-economic disadvantage, comorbidities, and unmet information needs were associated with decreased quality of life scores, while higher social difficulties were related to socio-economic disadvantage, comorbidities, and unmet information needs. Comorbidities partially mediated the impact of socio-economic disadvantage on quality of life outcomes.
SUPPORTIVE CARE IN CANCER
(2022)
Letter
Oncology
Sarah Glewis, Marliese Alexander, Senthil Lingaratnam, Benjamin Lee, Ian Campbell, Mei Krishnasamy, Maarten IJzerman, Mussab Fagery, Sam Harris, Chloe Georgiou, Craig Underhill, Mark Warren, Robert Campbell, Jennifer Martin, Jeanne Tie, Michael Michael
Article
Pediatrics
Luiza R. Grazziotin, Gillian Currie, Marinka Twilt, Maarten J. IJzerman, Michelle M. A. Kip, Hendrik Koffijberg, Gouke Bonsel, Susanne M. Benseler, Joost F. Swart, Sebastiaan J. Vastert, Nico M. Wulffraat, Rae S. M. Yeung, Wineke Armbrust, J. Merlijn van den Berg, Deborah A. Marshall
Summary: This study examines the relationship between measurements of child, caregiver, and caring context and the care-related quality of life (CRQoL) and health-related quality of life (HRQoL) of caregivers of children with juvenile idiopathic arthritis (JIA). The findings suggest that in addition to child HRQoL, socioeconomic factors such as employment and support for caregiving tasks are also associated with caregiver's quality of life.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Oncology
Sophie O'Haire, Koen Degeling, Fanny Franchini, Ben Tran, Stephen J. Luen, Clara Gaff, Kortnye Smith, Stephen Fox, Jayesh Desai, Maarten IJzerman
Summary: This study evaluated the clinical effectiveness of complex genomic profiling (CGP) in improving overall survival in advanced cancer patients. The results showed that patients who received treatment based on CGP results had improved survival. However, there was no significant survival benefit observed when comparing the entire CGP cohort with the cohort that did not undergo CGP analysis.
Article
Multidisciplinary Sciences
Frederik A. van Delft, Milou Schuurbiers, Mirte Muller, Sjaak A. Burgers, Huub H. van Rossum, Maarten J. IJzerman, Hendrik Koffijberg, Michel M. van den Heuvel
Summary: This study compares nine prediction methods using longitudinal tumor biomarker data to accurately and with a low false positive rate predict non-response to immunotherapy in NSCLC patients. The study evaluated nine models of varying complexity and demonstrated the usefulness of longitudinal biomarker data in predicting treatment response.
Article
Health Policy & Services
Joost J. Enzing, Saskia Knies, Jop Engel, Maarten J. IJzerman, Beate Sander, Rick Vreman, Bert Boer, Werner B. F. Brouwer
Summary: Despite the high attention given to manufacturers' costs in relation to drug prices in public and academic debates, this issue does not seem to be explicitly and systematically considered in reimbursement reports for expensive drugs.
COST EFFECTIVENESS AND RESOURCE ALLOCATION
(2022)
Article
Health Care Sciences & Services
Amanda Pereira-Salgado, Angelyn Anton, Fanny Franchini, Robert K. Mahar, Edmond M. Kwan, Shirley Wong, Julia Shapiro, Andrew Weickhardt, Arun A. Azad, Lavinia Spain, Ashray Gunjur, Javier Torres, Phillip Parente, Francis Parnis, Jeffrey Goh, Christopher Steer, Stephen Brown, Peter Gibbs, Ben Tran, Maarten IJzerman
Summary: The health economic outcomes of real-world treatment sequencing of androgen receptor-targeted agents (ARTA) and docetaxel (DOC) are unclear.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2023)
Review
Oncology
Allison Drosdowsky, Karen E. Lamb, Rebecca J. Bergin, Lucy Boyd, Kristi Milley, Maarten J. IJzerman, Jon D. Emery
Summary: Research on timely diagnosis and treatment of colorectal cancer is important for improving patient outcomes. This systematic review identified methodological issues in previous research, including arbitrary categorization and lack of adjustment for confounders. Recommendations include avoiding artificial categorization, ensuring proper sequencing of key events, and using theoretical frameworks to detect and reduce bias.
CANCER EPIDEMIOLOGY
(2023)
Article
Rheumatology
Gillian R. Currie, Catherina G. M. Groothuis-Oudshoorn, Marinka Twilt, Michelle M. A. Kip, Maarten J. IJzerman, Susanne M. Benseler, Joost F. Swart, Sebastiaan J. Vastert, Nico M. Wulffraat, Rae Yeung, Deborah A. Marshall
Summary: The care for JIA patients has changed in the biologics era, however, biologics have important risks and are expensive. Flares after biologic withdrawal are common, but there is little clinical guidance on which patients can safely discontinue their biologics. We conducted a survey to identify the characteristics that are important to pediatric rheumatologists when considering withdrawal of biologics.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Niels Jansen, Peter M. ten Klooster, Harald E. Vonkeman, Boudewijn van den Berg, Jan R. Buitenweg
Summary: This study investigated the role of Delta TSJ in understanding pain mechanisms and found that patients in the Delta TSJ >= 3 group showed significant differences in pain thresholds, pain levels, and disability. Pain catastrophizing and psychological hypervigilance did not play a significant role in these patients.
RHEUMATOLOGY ADVANCES IN PRACTICE
(2023)
Article
Oncology
Edwin Cuppen, Olivier Elemento, Richard Rosenquist, Svetlana Nikic, Maarten IJzerman, Isabelle Durand Zaleski, Geert Frederix, Lars-Ake Levin, Charles G. Mullighan, Reinhard Buettner, Trevor J. Pugh, Sean Grimmond, Carlos Caldas, Fabrice Andre, Ilse Custers, Elias Campo, Hans van Snellenberg, Anna Schuh, Hidewaki Nakagawa, Christof von Kalle, Torsten Haferlach, Stefan Froehling, Vaidehi Jobanputra
Summary: The combination of whole-genome and transcriptome sequencing (WGTS) is a comprehensive precision diagnostic test that is expected to transform diagnosis and treatment for cancer patients. However, there are barriers to the implementation and widespread adoption of this test, including considerations of utility in different cancer types, cost-effectiveness and affordability.
JCO PRECISION ONCOLOGY
(2022)
Article
Economics
William Padula, Noemi Kreif, David J. Vanness, Blythe Adamson, Juan-David Rueda, Federico Felizzi, Pall Jonsson, Maarten J. IJzerman, Atul Butte, William Crown
Summary: Advances in machine learning and artificial intelligence have great potential benefits in healthcare, including health economics and outcomes research. Machine learning can enhance these areas by analyzing big data effectively. However, a lack of transparency in how machine learning methods deliver solutions, especially in unsupervised circumstances, increases risk when using machine learning results.
Article
Health Care Sciences & Services
Gillian R. Currie, Tram Pham, Marinka Twilt, Maarten J. IJzerman, Pauline M. Hull, Michelle M. A. Kip, Susanne M. Benseler, Glen S. Hazlewood, Rae S. M. Yeung, Nico M. Wulffraat, Joost F. Swart, Sebastian J. Vastert, Deborah A. Marshall
Summary: This study explores pediatric rheumatologists' approaches to treatment decision making for biologics in JIA, identifying attributes influencing initiation and tapering. Five pediatric rheumatologists participated in interviews, outlining varied tapering strategies. Fourteen attributes were selected for a BWS survey, covering patient characteristics and contextual factors. Additional research is needed to align these characteristics with patient and parent preferences.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2022)
