Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 38, Issue 6, Pages 1223-1231Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-014-0472-8
Keywords
Depression; Stillen (TM); Forced swimming test; Serotonin; Brain-derived neurotrophic factor; Estrogen receptor-beta
Categories
Funding
- Hoseo University [2014-0077]
Ask authors/readers for more resources
Stillen (TM) has been used to treat patients with gastric mucosal ulcers and has an anti-inflammatory effect. It is well-known that neuro-inflammatory reactions are related to depression. Here we evaluated the antidepressant-like effect of Stillen (TM) on mice subjected to the forced swimming test (FST). Stillen (TM) and eupatilin (a major component of Stillen (TM)) significantly decreased immobility times compared with the FST control group. In the Stillen (TM)-administered group, increased levels of 5-hydroxytryptamine (serotonin) and brain-derived neurotrophic factor protein were observed in the hippocampus. Nissl bodies also increased in the hippocampus neuronal cytoplasm of the Stillen (TM)-administered group. Stillen (TM) decreased levels of interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha (at the mRNA and protein levels) in the hippocampus and serum, compared with the control group. In addition, the mRNA expression of estrogen receptor-beta increased after Stillen (TM) administration in the hippocampus. These findings suggest that Stillen (TM) should be viewed as a candidate antidepressant.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available