Article
Biochemistry & Molecular Biology
Meng Tang, Chaohan Li, Cheng Zhang, Youming Cai, Yongchun Zhang, Liuyan Yang, Moxian Chen, Fuyuan Zhu, Qingzhu Li, Kehu Li
Summary: Alkaloids are nitrogen-containing alkaline organic compounds with important biological activity and are essential active ingredients in Chinese herbal medicine. Amaryllidaceae plants are rich in alkaloids, including galanthamine, lycorine, and lycoramine. This study analyzed the alkaloid content in Lycoris longituba, Lycoris incarnata, and Lycoris sprengeri, and used a SWATH-MS-based quantitative approach to detect proteome changes. The results revealed differentially expressed proteins involved in specific biological processes, suggesting a supportive role for Amaryllidaceae alkaloid metabolism. Key genes responsible for galanthamine biosynthesis were identified, and RNA processing-related proteins were found abundantly in alkaloid-rich Lycoris, indicating a potential role of posttranscriptional regulation in alkaloid biosynthesis. Overall, this proteomic investigation provides a comprehensive reference for understanding the regulatory metabolism of Amaryllidaceae alkaloids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agricultural Engineering
Liya Hong, Yuanyuan Ji, Edward J. Kennelly, Chunlin Long, Rong Di
Summary: This study screened and characterized Amaryllidaceae alkaloids from various Lycoris species and found that galanthamine, one of these alkaloids, has potential therapeutic effects against Alzheimer's disease. Galanthamine reduced toxicity and neurodegeneration caused by amyloid beta and inhibited the expression of related genes.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Plant Sciences
Jiayu Zhou, Ioannis A. Stringlis, Jian Wen, Yifang Liu, Sheng Xu, Ren Wang
Summary: This study investigates the interplay between Amaryllidaceae alkaloids (AAs) and the bacteriome in Lycoris radiata. It finds that AAs have varying levels of antimicrobial activity against endophytic bacteria and pathogenic fungi. Additionally, it discovers a positive feedback loop between bacteria insensitive to AAs and their ability to increase AAs accumulation in L. radiata, providing benefits to the plants when challenged with fungal pathogens.
Article
Agronomy
Yi Lv, Yike Gao, Yuxuan Cui, Ying Wang, Zhuping Fan, Chunjing Guan, Qixiang Zhang
Summary: This study successfully obtained hybrid plants between daylily and lycoris through artificial pollination and embryo rescue, providing a new approach to enriching the genetic variation of plants.
Article
Pharmacology & Pharmacy
Katerina Hradiska Breiterova, Aneta Ritomska, Diana Fontinha, Jana Kroustkova, Daniela Suchankova, Anna Host'alkova, Marcela Safratova, Eliska Kohelova, Rozalie Perinova, Rudolf Vrabec, Denise Francisco, Miguel Prudencio, Lucie Cahlikova
Summary: This study evaluated the activity of a variety of Amaryllidaceae alkaloids and their derivatives against the hepatic stage of Plasmodium infection. Some newly synthesized compounds showed nanomolar level activity, but similar derivatives of haemanthamine did not display significant activity. The liver-selective compounds are considered crucial for the development of malaria prophylactics.
Article
Biochemistry & Molecular Biology
Darja Koutova, Radim Havelek, Eva Peterova, Darina Muthna, Karel Kralovec, Katerina Breiterova, Lucie Cahlikova, Martina Rezacova
Summary: Pancracine, a potent compound among natural isoquinolines, exhibited strong antiproliferative activity on A549 cells and induced apoptotic cell death in MOLT-4 cells. The mechanistic understanding of pancracine activity in vitro revealed perturbation of the cell cycle and induction of apoptotic cell death as key mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Fengjiao Zhang, Ning Wang, Guanghao Cheng, Xiaochun Shu, Tao Wang, Weibing Zhuang, Ruisen Lu, Zhong Wang
Summary: The genus Lycoris consists of around 20 plant species with high ornamental and medicinal value, but difficulty persists in germplasm identification due to hybridization and variation. This study used chloroplast genome sequencing and phylogenetic analysis to provide insights and a genomic platform for the genus Lycoris.
Article
Medicine, General & Internal
Mariola Herbet, Jaroslaw Widelski, Iwona Piatkowska-Chmiel, Kamil Pawlowski, Aleksandra Dymek, Tomasz Mroczek
Summary: This study evaluated the safety and pharmacological activity of compounds obtained from various plant extracts, and found that these compounds have a high safety profile and significantly improve rodent memory.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Plant Sciences
Luciana R. R. Tallini, Edison H. H. Osorio, Strahil Berkov, Laura Torras-Claveria, Maria L. Rodriguez-Escobar, Francesc Viladomat, Alan W. W. Meerow, Jaume Bastida
Summary: Plant biodiversity is a significant source of medicinal compounds. This study identified and analyzed the alkaloid profiles of three different Rauhia species from Peru, and evaluated their potential application in the treatment of Alzheimer's disease. The results showed that R. multiflora is an important natural source of galanthamine-type structures, which could be used for the development of biotechnological tools for sustainable production of galanthamine.
Article
Agronomy
Siwei Qiao, Jingyuan Yao, Qizhi Wang, Linwei Li, Bi Wang, Xu Feng, Zhong Wang, Min Yin, Yu Chen, Shu Xu
Summary: This study found that extracts from seven Lycoris species have excellent inhibitory effects on Magnaporthe oryzae. The alkaloids lycorine and narciclasine were identified as the main active components. Both the extracts and lycorine showed good antifungal activities against M. oryzae in vitro and in vivo.
PEST MANAGEMENT SCIENCE
(2023)
Article
Plant Sciences
Ngoc-Thao-Hien Le, Steven De Jonghe, Kristien Erven, Johan Neyts, Christophe Pannecouque, Tom Vermeyen, Wouter A. Herrebout, Luc Pieters, Emmy Tuenter
Summary: Scadoxus multiflorus is traditionally used for respiratory problems and this study investigated its alkaloidal composition. A previously undescribed alkaloid and fourteen known ones were identified. Some of the alkaloids exhibited weak antiviral activity against SARS-CoV-2, highlighting the potential of S. multiflorus as a source for anti-SARS-CoV-2 Amaryllidaceae alkaloid scaffolds.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Wenjing Ma, Siyu Wang, Yihai Wang, Jia Zeng, Jingwen Xu, Xiangjiu He
Summary: Seven undescribed Amaryllidaceae alkaloids and seven known alkaloids were isolated from the bulbs of Hymenocallis littoralis. These alkaloids exhibited antiproliferative activity and the potential to inhibit tumor cell migration, and could induce apoptosis.
Review
Plant Sciences
Youstina Refaat Boshra, John Refaat Fahim, Ashraf Nageeb Elsayed Hamed, Samar Yehia Desoukey
Summary: Narcissus pseudonarcissus, also known as wild daffodil or lent lily, is a popular plant with ornamental, folk, and medicinal importance. Its chemical composition, particularly the alkaloids, has been extensively studied. In addition to alkaloids, it also contains flavonoids, phenolics, terpenoids, and volatile compounds. The plant exhibits various bioactivities, including antibacterial, antifungal, and enzyme inhibitory actions. Further research is needed to explore its potential applications in therapeutics and pharmaceuticals.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Microbiology
Mauricio Pineiro, Javier E. Ortiz, Renata Spina M. Zapata, Patricia A. Barrera, Miguel A. Sosa, German Roitman, Jaume Bastida, Gabriela E. Feresin
Summary: Seven Argentinean Hippeastrum species were found to have strong antiparasitic and anticholinesterase activities. The alkaloids and cholinesterase inhibitors in these plant extracts showed potential in the treatment of Chagas disease. The combination of montanine and benznidazole demonstrated a synergistic effect.
Article
Plant Sciences
Marilu Roxana Soto-Vasquez, Paul Alan Arkin Alvarado-Garcia, Edison H. Osorio, Luciana R. Tallini, Jaume Bastida
Summary: The antileishmanial activity of an alkaloid extract from Clinanthus milagroanthus bulbs was evaluated against Leishmania braziliensis. The extract inhibited the growth of the parasite at different concentrations and showed potential binding capabilities with a specific enzyme. This study provides scientific evidence for the development of bioactive molecules from C. milagroanthus.
