Article
Chemistry, Multidisciplinary
Nechikkottil Sivadasan Sumitha, Prabha Prakash, Balagopal N. Nair, Gopalakrishnanchettiar Sivakamiammal Sailaja
Summary: Glyoxal cross-linked porous magnetic chitosan microspheres (GMS) were synthesized using a water-in-oil emulsion technique for controlled delivery of doxorubicin (DOX) with prolonged chemotherapeutic effects. GMS exhibited superparamagnetism and excellent cytocompatibility, with a release mechanism involving diffusion-inspired release through the swollen polymer network and regulated degradation release.
Article
Polymer Science
Pavel Yudaev, Anastasia Semenova, Evgeniy Chistyakov
Summary: A method for obtaining a polymer porous gel and coating based on nontoxic and environmentally friendly components has been developed. The gel exhibits high sorption capacity, high porosity, low density, and soil degradability, making it a promising material for environmental purification from oil pollution.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Microbiology
Yan Lv, Lijia Su, Zihang Zhao, Jinying Zhao, Huahua Su, Zhikai Zhang, Yanhua Wang
Summary: This study aims to fabricate a novel CS microspheres co-delivered curcumin (Cur) and gallic acid (Ga) to assess drug loading and release kinetics, the blood compatibility and anti-osteosarcoma properties. Cur-Ga-CS microspheres present high entrapment rate for Ga and Cur and exhibit slowly sustainable release for almost 7 days in physiological buffer. Importantly, these microspheres possess negligibly toxic to blood and normal BMSC cells, but strong anti-osteosarcoma effect on U2OS cells. Overall, Cur-Ga-CS microspheres are promising to become a novel anti-osteosarcoma agent or sustainable delivery carrier in biomedical applications.
CURRENT MICROBIOLOGY
(2023)
Article
Engineering, Biomedical
Hadis Eghbali, Mohsen Sadeghi, Mojgan Noroozi, Fahimeh Movahedifar
Summary: The crosslinking of chitosan and vanillin was studied, and compared with chitosan crosslinked with glutaraldehyde. The results showed that the chitosan-vanillin hydrogel exhibited good antibacterial activity and cell viability, but had weaker mechanical properties in the dry state.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Padala Abdul Nishad, Arjun Ajaykumar, Anupkumar Bhaskarapillai
Summary: This study reports the optimised synthesis of N-carboxymethylated chitosan (CM-Cts) and its crosslinking with glutaraldehyde to obtain CM-Cts-Glu as a metal ion sorbent. CM-Cts-Glu showed better metal ion uptake properties compared to crosslinked chitosan (Cts-Glu), and the sorption-desorption kinetics indicated the feasibility of reusing CM-Cts-Glu without any loss in capacity. The maximum Co(II) uptake obtained for CM-Cts-Glu was 265 μmol/g, while for Cts-Glu it was 10 μmol/g. The metal ion sorption by CM-Cts-Glu was through chelation by the carboxylic acid functional groups present over the chitosan backbone. The study also confirmed the utility of CM-Cts-Glu in complexing decontamination formulations used in the nuclear industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Menghua Chen, Mengdie Yu, Runfeng Kang, Huimin Sun, Wang Zhang, Shengsen Wang, Nong Wang, Jun Wang
Summary: In this paper, new adsorbents with high mechanical strength, chitosan-graphene oxide and chitosan-titanium dioxide, were synthesized and investigated for their adsorption behavior towards lead and vanadium. The study found that chemical adsorption was the main adsorption force and the Langmuir and Freundlich models fit well with the experimental data.
Article
Chemistry, Multidisciplinary
Xuan Ji, Yao Li, Suo Wang, Xu Fei, Jing Tian, Longquan Xu, Yi Wang
Summary: This study successfully immobilized lipase by modifying magnetic hydrogel microspheres, resulting in improved stability and activity of the enzyme. The produced lipase/tannic acid magnetic hydrogel microspheres exhibited sustained high catalytic activity through consecutive cycles of reactions.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Applied
Jelena Milinkovic Budincic, Lidija Petrovic, Ljiljana Dekic, Jadranka Fraj, Sandra Bucko, Jaroslav Katona, Ljiljana Spasojevic
Summary: This study investigated the potential benefits of microencapsulation and the impact of different wall materials on the performance of microcapsules. It found that chitosan/SLES complex can be used as a wall material for microencapsulation of hydrophobic active molecules in the cosmetic industry, achieving high encapsulation efficiency without the use of aldehydes as cross-linking agents.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Candy del Carmen Gamboa-Solana, Martha Gabriela Chuc-Gamboa, Fernando Javier Aguilar-Perez, Juan Valerio Cauich-Rodriguez, Rossana Faride Vargas-Coronado, David Alejandro Aguilar-Perez, Jose Ruben Herrera-Atoche, Neith Pacheco
Summary: The study prepared different composite material films and found that one containing chitosan crosslinked with glutaraldehyde exhibited antimicrobial activity against S. aureus, while all films showed antimicrobial activity against S. typhimurium. These findings suggest that chitosan composite films have potential applications in the medical and food industry fields.
Article
Environmental Sciences
Qibo Liu, Yonghui Wang, Xueli Liu, Shuang Li, Shuyue Ren, Zhixian Gao, Tie Han, Zhangrun Xu, Huanying Zhou
Summary: Researchers have designed and synthesised a magnetic adsorbent with improved physicochemical properties, which can effectively remove heavy metals and bacteria from polluted water. The adsorption mechanism of the adsorbent is mainly electrostatic adsorption, and it has a stable structure and is easy to separate.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Polymer Science
Ahmed A. Alshahrani, Abeer A. El-Habeeb, Noor H. Alotaibi, Anfal A. Shaman, Wajd F. Almutairi, Samar M. Alotaibi, Hassan M. Hassan, Ibrahim Hotan Alsohaimi
Summary: Nanofiltration membranes were successfully fabricated using multi-walled carbon nanotubes, and the type of carbon nanotubes used significantly influenced the membrane characteristics. The introduction of carbon with carboxylic or amine groups altered the surface morphology of the membranes. Additionally, membranes modified with carboxylic groups exhibited higher water permeability.
Article
Polymer Science
Wei Song, Qingzhu Zhang, Yuxin Guan, Wanyan Li, Siyu Xie, Jin Tong, Mo Li, Lili Ren
Summary: Porous chitosan/saccharomycetes adsorption microspheres were successfully prepared and characterized in terms of morphology, molecular interaction, and crystallization property. The microspheres showed potential in removing preservatives, pigments, and other additives in food. The surface roughness of microspheres could be improved by increasing the mass ratio of saccharomycetes, while the microsphere structure became more compact with the increase of silica gels.
Article
Polymer Science
Oliver J. Pemble, Maria Bardosova, Ian M. Povey, Martyn E. Pemble
Summary: Chitosan-based films face commercial limitation due to a lack of specific methods for high-volume production of thin films. Hydrogels made from chitosan, TEOS, and glutaraldehyde were used to create continuous thin films via a slot-die technique, showing higher mechanical strength compared to films made with chitosan alone. Testing on plain chitosan samples revealed no mechanical anisotropy induced by the slot-die process, demonstrating potential for cost-effective high-volume production of chitosan-based films for various applications.
Article
Engineering, Biomedical
Diana R. Fonseca, Ana Moura, Victoria Leiro, Ricardo Silva-Carvalho, Berta N. Estevinho, Catarina L. Seabra, Patricia C. Henriques, Monica Lucena, Catia Teixeira, Paula Gomes, Paula Parreira, M. Cristina L. Martins
Summary: The bioengineered approach of grafting MSI-78A onto chitosan microspheres enhances its bactericidal performance against Helicobacter pylori. The conjugation does not compromise the antimicrobial activity of MSI-78A and even boosts its effectiveness against H. pylori, making it a potential alternative for antibiotic therapy.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Asma Amjlef, Salaheddine Farsad, Ayoub Chaoui, Aboubakr Ben Hamou, Mohamed Ezzahery, Said Et-Taleb, Noureddine El Alem
Summary: In this study, quartz sand (QS) incorporated into a crosslinked chitosan-glutaraldehyde matrix (QS@Ch-Glu) was prepared and employed as an efficient adsorbent for the elimination of Orange G (OG) dye from water. The sorption process followed the pseudo-second order kinetic model and the Langmuir isotherm model. The adsorption mechanism of OG on QS@Ch-Glu involved electrostatic attractions, n-pi stacking interaction, hydrogen bonding interaction, and Yoshida hydrogen bonding. The adsorption rate of QS@Ch-Glu remained above 95% even after 6 cycles of adsorption and desorption. Furthermore, QS@Ch-Glu demonstrated high efficiency in real water samples.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Sapan Shah, Dinesh Chaple, Sumit Arora, Subhash Yende, Chetan Mehta, Usha Nayak
Summary: This study aims to explore the potential resistance of active chemical constituents from Cressa cretica against SARS-CoV-2, and molecular dynamics simulations have validated the good binding affinity of 3,5-Dicaffeoylquinic acid and Quercetin to M-pro. These findings suggest their potential as novel research molecules for the treatment of COVID-19.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Suman Manandhar, Keerthi Priya, Chetan H. Mehta, Usha Y. Nayak, Shama Prasada Kabekkodu, K. Sreedhara Ranganath Pai
Summary: Alzheimer's disease is a common and progressive form of dementia, and research suggests that antidiabetic medications may have a beneficial effect on the disease through modulation of the Wnt signaling pathway, but further experimental studies are needed for verification.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Pharmacology & Pharmacy
Om Prakash Ranjan, Nitesh Kumar, Vivek Dave
Summary: This study aims to prepare delayed-release beads containing montelukast sodium for chronotherapy of asthma. The optimal formulation of these beads was found, and the study showed that when these beads were administered at sleep time, they could effectively relieve early morning symptoms in asthmatic patients.
CURRENT DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Akhil Suresh, Reema Narayan, Hari Prabhath Tummala, Saikumar Matcha, Surulivelrajan Mallayasamy, Yogendra Nayak, Jagadish Puralae Channabasavaiah, Usha Y. Nayak
Summary: This study aimed to improve the oral bioavailability of asenapine maleate using bio-enhancers. Quercetin was found to be the most effective bio-enhancer, significantly increasing the pharmacokinetic parameters of asenapine maleate.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Reema Narayan, Shivaprasad Gadag, Sanjay Garg, Usha Y. Nayak
Summary: In this study, a computational model was developed to investigate the adsorption and release mechanism of the drug 5-FU on the surface of MCM-41. Molecular mechanics simulations and quantum mechanical calculations revealed that surface substitutions on MCM-41 improved the interactions with the drug, and the release rate of 5-FU was slower on the MCM-NH2 surface.
Article
Virology
Varalakshmi Velagacherla, Akhil Suresh, Chetan Hasmukh Mehta, Usha Y. Nayak, Yogendra Nayak
Summary: COVID-19, caused by SARS-CoV-2, is a global pandemic that originated in Wuhan, China. Drug discovery teams worldwide are racing to find a treatment for this disease. Repurposing already approved drugs is an ideal approach to expedite the process. We used the Schrodinger suite for in silico predictions to screen selected molecules with an affinity for multiple protein targets in COVID-19. Through molecular docking, MM-GBSA, IFD, and MD simulations, we identified nintedanib as the most suitable molecule with high binding stability to viral proteins. Nintedanib, primarily used for idiopathic pulmonary fibrosis, shows potential for repurposing against COVID-19.
Article
Biochemistry & Molecular Biology
E. Vignesh Balaji, Sairaj Satarker, B. Harish Kumar, Samyak Pandey, Sumit Raosaheb Birangal, Usha Y. Nayak, K. Sreedhara Ranganath Pai
Summary: This study aimed to identify novel molecules that could simultaneously inhibit IDH1 and IDH2 for the management of glioblastoma and other cancers. Through molecular docking, simulations, and molecular dynamics analysis, four potential compounds were identified. These compounds showed maximum interaction with crucial amino acids in IDH1 and IDH2 and could potentially combat glioblastoma. However, further in vitro and in vivo studies are needed to validate the findings of this study.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Pharmacology & Pharmacy
Tejaswini Kolipaka, Srijita Sen, Sayalee Sanjay Mane, Gopal D. Bajad, Swapnil Jayant Dengale, Om Prakash Ranjan
Summary: A posaconazole nanosuspension was successfully formulated and optimized using a wet milling process. The nanocrystals, with an average particle size of 395.7 nm and a PDI of 0.30, showed improved solubility and release compared to pure posaconazole. In vivo pharmacokinetic results demonstrated significantly increased Cmax and AUC for the posaconazole nanocrystals.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Srijita Sen, Joyal Xavier, Nitesh Kumar, Mohammad Zaki Ahmad, Om Prakash Ranjan
Summary: Exosomes, nanosized vesicular structures, have gained popularity due to their advantages as therapeutic carriers and diagnostic markers. Surface modification of exosomes can increase their circulation time and enable targeted drug delivery. This review provides a comprehensive overview of exosome composition, biogenesis, and their role in intercellular signaling, immune responses, and infectious diseases. The clinical implications of exosomes as therapeutic agents and diagnostic markers are discussed, along with the challenges and future perspectives in exosome research.
Article
Immunology
Chetan Hasmukh Mehta, Shivangi Paliwal, Manjunatha S. Muttigi, Raviraja N. Seetharam, Alevoor Srinivas Bharath Prasad, Yogendra Nayak, Shruthi Acharya, Usha Yogendra Nayak
Summary: Oral submucous fibrosis (OSF) is a chronic and precancerous condition caused by chewing areca nut, and current therapy has limited success. In this study, a combined approach of in silico, in vitro and in vivo methods was used to select the most suitable polyphenols for OSF treatment. Epigallocatechin-3-gallate (EGCG), quercetin (QUR), resveratrol, and curcumin showed high affinity and stability with the selected protein targets. In vitro and in vivo studies demonstrated that EGCG was safer and more effective in reducing fibrosis-related markers than QUR. The findings suggest that EGCG can be a potential and safer phytomolecule for OSF therapy.
INFLAMMOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
T. Ashwini, Ashlesh Prabhu, Vishal Baliga, Shreesha Bhat, Siddarth T. Thenkondar, Yogendra Nayak, Usha Y. Nayak
Summary: Wound healing is a complex process that can be further complicated in chronic wounds. Nanotechnology has shown great promise in developing advanced wound dressings. This review article provides a comprehensive search strategy and an updated overview of the different types of nanomaterials used in wound dressings. It also highlights the potential benefits of using nanomaterials in wound care and serves as a valuable resource for clinicians, researchers, and patients.
Article
Pharmacology & Pharmacy
Srijita Sen, Atul Pandurang Kumbhar, Jayesh Rajesh Patil, Om Prakash Ranjan
Summary: Burns are critical medical conditions that require continuous monitoring and nanofibers have shown to be an excellent biomedical tool for improving the treatment and repair of burn wounds.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Medicinal
Saritha Keluth, Srikanth Jitte, Rashmi Bhushan, Om Prakash Ranjan, Krishna Murti, Velayutham Ravichandiran, Nitesh Kumar
Summary: This study explores the targeting of distinct ion channels for glioma treatment and summarizes their activity in glioma pathogenesis. The research found several side effects for current chemotherapy and highlights the innovative roles of ion channels in glioma regulation.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Polymer Science
Jaahnavi Lanka, Santhosh Kumar, Mohana B. Kumar, Shama Rao, Shivaprasad Gadag, Usha Y. Nayak
Summary: Hyaluronic acid (HA) and zinc oxide gels were evaluated for their drug release and cytotoxicity. The study found that low molecular weight-HA was more effective than high molecular weight-HA. Zinc oxide gels were toxic to gingival and periodontal ligament fibroblasts.
DESIGNED MONOMERS AND POLYMERS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Bharath Kumar Ayyanahalli Matta, Santhosh Kumar, Chetan Hasmukh Mehta, Usha Yogendra Nayak, Patricia Garcia Rodriguez
Summary: This study investigates the cytotoxicity and hemostatic properties of Calendula officinalis and gelatin sponge. The results demonstrate that Calendula officinalis exhibits good cytocompatibility and cell proliferation, and when incorporated into gelatin sponge, it reduces clot formation time.