Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 33, Issue 3, Pages 451-456Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-010-0315-1
Keywords
Processed Aloe vera gel; Immunomodulation; C. albicans; Cytotoxic T lymphocyte
Categories
Funding
- Korean Ministry of Education, Science and Technology
- Research Center for Bioresource and Health
- Kiat MKE
Ask authors/readers for more resources
The gels of Aloe species contain immunomodulatory components such as aloctin A and acemannan. Most studies on these gels were performed in in vitro cell culture systems. Although several studies examined their immunomodulatory activity in vivo, the route of administration was intraperitoneal or intramuscular. Here, we evaluated the in vivo immunomodulatory activity of processed Aloe vera gel (PAG) in mice. Oral administration of PAG significantly reduced the growth of C. albicans in the spleen and kidney following intravenous injection of C. albacans in normal mice. PAG administration also reduced the growth of C. albicans in streptozotocin-induced diabetic mice. PAG administration did not increase ovalbumin (OVA)specific cytotoxic T lymphocyte (CTL) generation in normal mice, but did increase it in high-fat-diet induced diabetic mice. These findings provide the first clear evidence for the immunomodulatory activity of orally administered Aloe vera gel.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available