Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 33, Issue 12, Pages 1891-1900Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-010-1202-5
Keywords
Aroylhydrazones; 5-Amino-4-cyanopyrazole; Quinazoline-4-one; Antimicrobial activity
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New substituted aroylhydrazones (4a-f) were synthesized from the acid hydrazide (3) and the corresponding aldehyde or aldose. 5-Amino-4-cyano-1H-pyrazole derivatives (6a-f) were prepared by the reaction of the aroylhydrazones (4a-f) with malononitrile. The synthesized compounds were tested for antimicrobial activity against various bacteria and fungi and showed moderate to high inhibition activities. Compounds incorporating a sugar moiety as well as a pyrazolyl ring in their structure displayed the highest antimicrobial activity.
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