Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 33, Issue 10, Pages 1489-1507Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-010-1003-x
Keywords
Dorsal root ganglia; Nociceptors; Ion channels; Pain
Categories
Funding
- CNRS
- National Research Agency [ANR-Neuro2006]
- Medical Research Foundation (FRM)
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Pain sensation (nociception) is an alarm system aiming to signal the presence of potentially or actually harmful stimuli. In our hazard-rich environment, pain initiates the necessary reactions to prevent or limit tissue damage in response to noxious inputs playing therefore a crucial survival role. Specialized noxious stimuli detectors, called primary nociceptive neurons or nociceptors transduce and convey pain information to the central nervous system. Unlike other sensory systems, pain sensation could be evoked by a vast range of external or internal stimuli. Nearly any of the environmental stimuli could be potentially noxious depending on their nature and/or intensity and/or duration. Early studies at the beginning of the 20(th) century identified a discrete number of nociceptive neuronal types according to their electrophysiological responses or their degree of myelination. However, the advent of molecular biology techniques revealed an extraordinary diversity among nociceptors. Such heterogeneity likely reflects the evolutionary adaptation required to respond to an extremely variety of circumstances.
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