Article
Food Science & Technology
Shuaishuai Chen, Weiyu Guo, Huan Liu, Jiang Zheng, Dingyan Lu, Jia Sun, Chun Li, Chunhua Liu, Yonglin Wang, Yong Huang, Wen Liu, Yongjun Li, Ting Liu
Summary: Psoralen and isopsoralen are major components responsible for Psoraleae Fructus-induced hepatotoxicity. This study reveals that their cytotoxic effects are mediated by metabolic activation through cytochrome P450 (CYP) enzymes. Specific CYP enzymes, such as CYP2C9, 2C19, 2D6, and 2E1, play a crucial role in the metabolic activation of psoralen and isopsoralen. The activation of these compounds by CYP enzymes regulates core targets and signaling pathways, resulting in cytotoxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lei He, Donglin Feng, Hui Guo, Yueyuan Zhou, Zhaozhao Li, Kuo Zhang, Wangqian Zhang, Shuning Wang, Zhaowei Wang, Qiang Hao, Cun Zhang, Yuan Gao, Jintao Gu, Yingqi Zhang, Weina Li, Meng Li
Summary: This study provides the first analysis of the pharmacokinetics of BPC157, showing linear pharmacokinetic characteristics in rats and beagle dogs. The main excretory pathways of BPC157 were found to be urine and bile. These findings are important for the clinical translation of BPC157.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wenhao Cheng, Siyang Wu, Zheng Yuan, Weiyu Hu, Xin Yu, Nianxin Kang, Qiutao Wang, Mingying Zhu, Kexin Xia, Wei Yang, Chen Kang, Shuofeng Zhang, Yingfei Li
Summary: Through a multicompound pharmacokinetic analysis, the tissue distribution and excretion characteristics of Radix Polygoni Multiflori (RPM) components were investigated. The findings showed that the active ingredients of RPM were quickly absorbed after oral administration and had high tissue distribution in the liver and kidney. These components were key contributors to the effectiveness and toxicity of RPM on the liver and kidney.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jingqi Li, Qi Zhang, Yutong Chen, Chengyu Lu, Yongbin Tong
Summary: This study investigated the pharmacokinetic parameters of demethyleneberberine and compared its pharmacokinetics, tissue distribution, and excretion in rats and mice for the first time. The results showed that demethyleneberberine had high bioavailability in animals, which is of great significance for pharmacological and clinical research.
Article
Pharmacology & Pharmacy
Xinchi Feng, Kun Wang, Shijie Cao, Liqin Ding, Feng Qiu
Summary: This study systematically investigated the pharmacokinetic and excretion profiles of berberine and its nine metabolites in rats. The results showed that berberine was rapidly metabolized and all nine metabolites could be detected in vivo. The excretion study revealed that 18.6% of berberine was excreted in feces as berberrubine.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Cai Zhang, Jin-Quan Zhao, Jia-Xing Sun, Hui-Jun Li
Summary: The study revealed that the hepatotoxicity induced by psoralen and isopsoralen is associated with the expression and activity of CYP1A2, possibly through the mechanism of AhR-mediated transcriptional induction of CYP1A2. These findings are important to alert about the potential risks of combined usage of psoralen or isopsoralen with AhR ligands or CYP1A2 substrates in clinical practice.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Cai Zhang, Song Fan, Jin-Quan Zhao, Yan Jiang, Jia-Xing Sun, Hui-Jun Li
Summary: The purpose of this study was to investigate the mechanism underlying psoralen/isopsoralen-induced hepatotoxicity. Through transcriptomic and metabolomic analyses, xenobiotic metabolism via cytochromes P450 was identified as a potential pathway. Further validation identified CYP1A2 as the key metabolic enzyme. Induction of CYP1A2 aggravated hepatotoxicity, while inhibition alleviated the toxic effects. Glutathione adducts with reactive intermediates of psoralen/isopsoralen were detected, suggesting that CYP1A2-mediated metabolic activation is responsible for the observed hepatotoxicity.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Ning Xiao, Feng Xiao, Jinzhang Gao, Zhengkun Xu, Qianlei Wang, Jiajie Kuai, Wei Wei, Chun Wang
Summary: The study showed that combined oral administration of CP-25 with LEF can promote the excretion of TER in urine, feces, and bile, while reducing its content in most tissues and organs, especially in the liver, potentially reducing LEF-induced liver injury.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kristyna Stefkova-Mazochova, Hynek Danda, Wim Dehaen, Bronislav Jurasek, Klara Sichova, Nikola Pinterova-Leca, Vladimir Mazoch, Barbora Hrcka Krausova, Bohdan o Kysilov, Tereza Smejkalova, Ladislav Vyklicky, Michal Kohout, Katerina Hajkova, Daniel Svozil, Rachel R. Horsley, Martin Kuchar, Tomas Palenicek
Summary: The study found that DCK has similar behavioral and addictive profiles to ketamine, with S-DCK being more active and having a slightly slower pharmacokinetic profile, which may result in a longer duration of action.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kunqian Mu, Kaiwen Jiang, Yue Wang, Zihan Zhao, Song Cang, Kaishun Bi, Qing Li, Ran Liu
Summary: A LC-MS/MS method was developed to study the in vivo fate of beta-cyclodextrin. The results showed that beta-cyclodextrin has a wide distribution in rats' bodies and is rapidly excreted, indicating low accumulation and good safety.
Article
Agriculture, Multidisciplinary
Yue Li, Teng Wang, Hao-Hao Shi, Yu-Ming Wang, Chang-Hu Xue, Qing-Rong Huang, Tian-Tian Zhang
Summary: Sea cucumber-derived sulfated sterols showed more significant bioactivities due to the unique structure of the sulfate group, but their absorption, pharmacokinetics, and tissue distribution remain unknown. This study investigated the absorption characteristics, pharmacokinetics, and tissue distribution of sea cucumber sterols, finding that they are absorbed quickly and mainly accumulate in the liver. These results provide insights for the development of functional foods and nutraceuticals containing sea cucumber sterols.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Xuguang Zhang, Zhenrui Xie, Xun Chen, Junqiang Qiu, Yinfeng Tan, Xiaoliang Li, Hailong Li, Junqing Zhang
Summary: Alpinia officinarum alters the pharmacokinetic parameters of indomethacin, reducing its systemic exposure and increasing elimination. Co-administration of A. officinarum does not reduce indomethacin accumulation in target tissues, but accelerates excretion of indomethacin and its metabolites. This suggests that A. officinarum may have a gastrointestinal protective effect through interactions with indomethacin in rats.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Chemistry, Medicinal
Liping Dong, Wenjuan Liu, Xiaoyuan Zhao, Feng Yu, Yungen Xu, Mengxiang Su
Summary: This study synthesized a novel limonin derivative, HY-071085, with strong anti-inflammatory and analgesic activity. The pharmacokinetics, bioavailability, distribution, and excretion of HY-071085 were evaluated in rats and beagle dogs. The results showed nonlinear dynamic characteristics and gender differences in the pharmacokinetics of HY-071085, as well as tissue distribution and excretion patterns.
Article
Chemistry, Medicinal
Kai Pan, Xiaolei Shi, Kai Liu, Ju Wang, Yijun Chen
Summary: The study introduced a novel long-acting insulin, INS061, and investigated its efficacy, pharmacokinetics, biodistribution, and excretion profiles in rats. INS061 demonstrated favorable glucose-lowering effects and pharmacokinetics, establishing a foundation for further preclinical and clinical evaluation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Zili Guo, Bianbian Gao, Miaoliang Fan, Lisha Chen, Changjun Zhang, Xianrui Liang, Weike Su, Yuanyuan Xie
Summary: The compound XYY-CP1106, synthesized from a hybrid of hydroxypyridinone and coumarin, has shown remarkable efficacy in treating Alzheimer's disease. Pharmacokinetic studies in rats have demonstrated that it is rapidly absorbed into the blood, has a half-life of 8.26-10.06 hours, and can pass through the blood-brain barrier with high content in brain tissue. Its excretion is mainly through feces with an average total excretion rate of 31.14% in 72 hours.
Article
Chemistry, Medicinal
Liang Feng, Ling Wang, Changjiang Hu, Xuehua Jiang
ARCHIVES OF PHARMACAL RESEARCH
(2010)
Article
Oncology
Liang Feng, Hang-Ping Yao, Wei Wang, Yong-Qing Zhou, Jianwei Zhou, Ruiwen Zhang, Ming-Hai Wang
CLINICAL CANCER RESEARCH
(2014)
Article
Chemistry, Medicinal
Hongzhuo Liu, Liang Feng, Gaurav Tolia, Mark R. Liddell, Jinsong Hao, S. Kevin Li
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2014)
Article
Chemistry, Multidisciplinary
Liang Feng, S. Kevin Li, Hongshan Liu, Chia-Yang Liu, Kathleen LaSance, Farzin Haque, Dan Shu, Peixuan Guo
PHARMACEUTICAL RESEARCH
(2014)
Article
Pharmacology & Pharmacy
Liang Feng, Jonette A. Ward, S. Kevin Li, Gaurav Tolia, Jinsong Hao, Daniel I. Choo
CURRENT DRUG DELIVERY
(2014)
Article
Pharmacology & Pharmacy
F Liang, JX Hua
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2005)