☆ 4.6 Article

Fluorenone alkaloid from Caulophyllum robustum Maxim. with anti-myocardial ischemia activity

ARCHIVES OF PHARMACAL RESEARCH (2009)

Journal

ARCHIVES OF PHARMACAL RESEARCH

Volume 32, Issue 4, Pages 521-526

Publisher

PHARMACEUTICAL SOC KOREA

DOI: 10.1007/s12272-009-1407-7

Keywords

Caulophyllum robustum Maxim.; Caulophine; Anti-myocardial ischemia

Categories

Chemistry, Medicinal Pharmacology & Pharmacy

Funding

Natural Science Foundation of China [30730110, 30801450]
Shaanxi Natural Science Foundation [2006C221]

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Abstract

A new fluorenone alkaloid (caulophine) was isolated from the radix of Caulophyllum robustum Maxim. (collected from the Qinling mountains) using cell membrane chromatography as the screening method. Caulophine was identified as 3-(2-(dimethylamino)ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one based on physicochemic and spectroscopic analyses, particularly by NMR spectroscopic data (i.e., COSY, HMQC, HMBC, NOESY). Caulophine possessed anti-myocardial ischemia activity.

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