Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 32, Issue 3, Pages 329-334Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-009-1303-1
Keywords
Chloranthaceae; Chloranthus japonicus Sieb.; Coumarinolignan glucoside; Benzofuran lignans; Cytotoxicity
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Funding
- National Natural Science Foundation of China [30772720]
- Technology Research Programs of Education institution of Heilongjiang Province [11521262]
- Science Foundation of Heilongjiang University of Chinese Medicine [200505]
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A new coumarinolignan glucoside named yinxiancaoside C, along with five known benzofuran lignans, have been isolated from the whole plant of Chloranthus japonicus Sieb. The structures of compounds 1-6 were elucidated by chemical and spectroscopic methods including 1D-NMR, 2D-NMR, ESI-MS and HR-ESI-MS. Five known benzofuran lignans were firstly discovered in the Chloranthaceae. In addition, the cytotoxic activity of the isolated compounds against human hepatoma (Hepg-2), ovarian carcinoma (OV420), and breast cancer (MCF-7) cells was investigated by MTT method.
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