Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 136, Issue 5, Pages 1170-1177Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2015.08.028
Keywords
Atopic dermatitis; eczema; sleep; sleep disturbance; circadian rhythms
Categories
Funding
- Jazz
- Department of Defense
- Office of Naval Research
- National Institutes of Health
- NASA
- Merck
- Vanda Pharmaceuticals
- Cadwell Diagnostics
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Children with atopic dermatitis (AD) experience significant sleep disruption, and clinically, the disease is noted to worsen in a circadian manner at night. Epidemiologic findings highlight many negative consequences of AD, such as impaired linear growth, which is uniquely related to disturbed sleep. Clinical guidelines currently recommend assessing sleep in patients with AD as a crucial parameter of disease control with appropriate treatment. In this review we describe our current understanding of the roles of sleep cycles and circadian rhythms in the nighttime exacerbation of AD (nocturnal eczema). We present a schematic to explain the mechanism of nocturnal eczema. Treatment options for sleep disturbance and future directions for research are discussed in the context of AD.
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