Article
Psychology, Developmental
Kelsey K. Wiggs, Rosanna Breaux, Joshua M. Langberg, James L. Peugh, Stephen P. Becker
Summary: This study examines the sleep differences in adolescents with ADHD who use stimulant medication. The findings suggest that stimulant treatment does not significantly affect the sleep of adolescents with ADHD.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Pediatrics
Nicole Hadler, Arianna Strome, Marika Waselewski, Kelsey Herbert, Chloe Harper, Tammy Chang
Summary: The study found that many youth believe peer pressure and coping are common reasons for stimulant diversion, with many perceiving that lots of youth misuse stimulants. They thought stimulants could be obtained from peers, people with prescriptions, dealers, and family members, and some even mentioned access through unnecessary prescriptions. Many were aware of the health risks of misuse, but few mentioned potential legal consequences.
JOURNAL OF PEDIATRICS
(2021)
Article
Psychology, Developmental
Sean Esteban McCabe, Olivia Figueroa, Vita V. McCabe, Ty S. Schepis, John E. Schulenberg, Philip T. Veliz, Kennedy S. Werner, Timothy E. Wilens
Summary: This study aimed to examine the relationship between age of onset and duration of stimulant therapy for ADHD and cocaine, methamphetamine, and prescription stimulant misuse in adolescence. The results showed that early initiation and longer duration of stimulant therapy were not associated with increased odds of cocaine or methamphetamine use. However, late initiation and shorter duration of stimulant therapy were significantly associated with higher odds of past-year cocaine or prescription stimulant misuse. There were no differences in misuse rates between individuals who received non-stimulant therapy for ADHD and those who initiated early and long-duration stimulant therapy.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Hsin-Yi Fan, Cheuk-Kwan Sun, Yu-Shian Cheng, Weilun Chung, Ruu-Fen Tzang, Hsien-Jane Chiu, Chun-Ning Ho, Kuo-Chuan Hung
Summary: This study provides a systematic review and analysis of the effectiveness of electroencephalogram-based neurofeedback (EEG-NF) in treating the core symptoms of attention-deficit hyperactivity disorder (ADHD) in adolescents/adults. The results suggest that EEG-NF can effectively improve inattention symptoms, but its effectiveness in reducing hyperactivity/impulsivity remains inconclusive.
SCIENTIFIC REPORTS
(2022)
Review
Neurosciences
Mairin Rose Taylor, Kelly Carrasco, Andres Carrasco, Arindam Basu
Summary: ADHD is a common neurodevelopmental disorder associated with increased dopamine receptor availability. It is linked to smoking and substance abuse. MAO inhibitors found in tobacco and e-cigarettes may contribute to smoking dependence among individuals with ADHD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Carrie M. Mintz, Kevin Y. Xu, Ned J. Presnall, Sarah M. Hartz, Frances R. Levin, Jeffrey F. Scherrer, Laura J. Bierut, Richard A. Grucza
Summary: The use of prescription stimulants is associated with a modest increase in the risk of drug-related poisoning among individuals receiving buprenorphine treatment for opioid use disorder (OUD). However, stimulant use is also associated with improved retention to buprenorphine treatment, providing protection against overdose.
Article
Psychology, Developmental
Deborah Winders Davis, Kahir Jawad, William David Lohr, Marie Trace, Jennifer Le, Yana Feygin, Veronnie Faye Jones
Summary: The study aimed to evaluate the adherence to the American Academy of Pediatrics' clinical guidelines in treating ADHD in preschoolers. Using Medicaid claims data, it was found that more than half of the sample did not receive the recommended behavioral therapy prior to medication initiation. Those who received behavioral therapy had a higher rate of ADHD diagnosis. Only three diagnoses were significant in multivariate analyses. Conclusion: More research is needed to identify intervention targets. Limitations are acknowledged.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Psychology, Clinical
Sylvia H. M. Wong, Courtney Stevens, Cindy H. Liu, Justin A. Chen
Summary: This study is the largest multi-institutional study to date on the correlates of prescription stimulant misuse (PSM) among US college students. It found that psychological disorders, substance abuse, and other addictive behaviors are associated with PSM. Additionally, academic difficulty, White race, and male gender are also associated with misuse behavior.
JOURNAL OF CLINICAL PSYCHIATRY
(2023)
Review
Clinical Neurology
Marina Silva de Lucca, Maria Eduarda Oliveira Pimentel, Cleuberton Kenedy Oliveira Raimundo, Bruno David Henriques, Tiago Ricardo Moreira, Silvia Almeida Cardoso, Debora Marques de Miranda
Summary: This review investigates the relationship between brain-derived neurotrophic factor (BDNF) levels in ADHD children before and after treatment with stimulant medication. The findings suggest that there is no significant difference in peripheral BDNF levels before and after methylphenidate treatment in ADHD children, and BDNF levels also do not differ from controls.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Microbiology
Yoon Jae Cho, Bokyoung Shin, Sung-Ha Lee, Sangmin Park, Yoon-Keun Kim, Jae-Jin Kim, Eunjoo Kim
Summary: This study analyzed urine microbiome profiles to explore the potential of the urine microbiome as a biomarker for pediatric ADHD. The ADHD group showed decreased alpha diversity and significant beta diversity differences compared to the control group. The genus Afipia exhibited significant correlations with ADHD symptoms, suggesting its potential as a biomarker for ADHD.
Article
Psychiatry
Feilong Zhu, Boya Liu, Dongqing Kuang, Xiaotong Zhu, Xiaoyu Bi, Yiqi Song, Tianshen Quan, Yiming Yang, Yuanchun Ren
Summary: This study found that moderate-to-vigorous physical activity may be beneficial for improving sleep in adult ADHD patients using stimulant medications. Adhering to the recommended guidelines of 150 minutes of physical activity per week is particularly important in reducing the risk of sleep problems, especially for men.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Mina Tadrous, Ahmad Shakeri, Cherry Chu, Jennifer Watt, Muhammad M. Mamdani, David N. Juurlink, Tara Gomes
Summary: A cohort study found that stimulant use was associated with an early increase in cardiovascular events among older adults, with no association for long-term use.
Article
Psychology, Developmental
Marieke Michielsen, Didi Kleef, Denise Bijlenga, Cinderella Zwennes, Kim Dijkhuizen, Jan Smulders, Andreia Hazewinkel, Aartjan T. F. Beekman, J. J. Sandra Kooij
Summary: The study found that 65% of older adults with ADHD had a positive response to medication, but 42% discontinued medication due to side effects or nonresponse. There was a slight decrease in weight and increase in heart rate after the use of methylphenidate.
JOURNAL OF ATTENTION DISORDERS
(2021)
Article
Behavioral Sciences
Brooke S. G. Molina, Heather M. Joseph, Heidi L. Kipp, Rachel A. Lindstrom, Sarah L. Pedersen, David J. Kolko, Daniel J. Bauer, Geetha A. Subramaniam
Summary: The study described the clinical and psychosocial characteristics of adolescents in pediatric primary care treatment for attention-deficit/hyperactivity disorder, focusing on the risk of stimulant diversion. Results showed that diversion was rare, but risk levels were higher for older adolescents, with minimal sex differences. Prevention measures could capitalize on current psychosocial strengths and discuss stimulant-specific attitudes, behaviors, and social norms to effectively address the risk of diversion.
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2021)
Article
Medicine, General & Internal
Ty S. Schepis, Kennedy S. Werner, Olivia Figueroa, Vita V. McCabe, John E. Schulenberg, Phil T. Veliz, Timothy E. Wilens, Sean Esteban McCabe
Summary: Attention-deficit/hyperactivity disorder (ADHD) is associated with higher substance use rates. The associations between ADHD pharmacotherapy and prescription stimulant misuse (PSM), cocaine, and methamphetamine use are unclear.
Review
Biochemistry & Molecular Biology
Stephen Faraone, Jeffrey H. Newcorn, Andrea Cipriani, Daniel Brandeis, Anna Kaiser, Sarah Hohmann, Alexander Haege, Samuele Cortese
Summary: The study analyzed the placebo and nocebo effects in ADHD medications, finding significant impact of placebo effects on efficacy and negative effects on tolerability. It also discovered a positive correlation between baseline to endpoint placebo effects and drug effects.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychology, Developmental
Timothy E. Wilens, Stephen Faraone, Paul G. Hammerness, Steven R. Pliszka, Cassandra L. Uchida, Norberto J. DeSousa, Floyd R. Sallee, Bev Incledon, Jeffrey H. Newcorn
Summary: By using established criteria for clinically meaningful improvements, it was found that delayed-release and extended-release methylphenidate (DR/ER-MPH) significantly improved early morning and late afternoon/evening functional impairment in children with ADHD, particularly compared to placebo.
JOURNAL OF ATTENTION DISORDERS
(2022)
Review
Behavioral Sciences
Sarah Kittel-Schneider, Gara Arteaga-Henriquez, Alejandro Arias Vasquez, Phil Asherson, Tobias Banaschewski, Isabell Brikell, Jan Buitelaar, Bru Cormand, Stephen Faraone, Christine M. Freitag, Ylva Ginsberg, Jan Haavik, Catharina A. Hartman, Jonna Kuntsi, Henrik Larsson, Silke Matura, Rhiannon McNeill, J. Antoni Ramos-Quiroga, Marta Ribases, Marcel Romanos, Isabella Vainieri, Barbara Franke, Andreas Reif
Summary: There is a correlation between ADHD and non-mental diseases, possibly due to shared pathologic mechanisms and genetic risk factors. Neglecting these co-occurring conditions may result in missed diagnoses and suboptimal treatment.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychiatry
Janet Wozniak, Maura DiSalvo, Abigail Farrell, Gagan Joshi, Mai Uchida, Stephen V. Faraone, Emmaline Cook, Joseph Biederman
Summary: This study found that remission of pediatric bipolar I disorder is rare, with most patients continuing to experience high levels of morbidity into late adolescence and early adulthood.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychology, Developmental
Corentin J. Gosling, Samuele Cortese, Eric Konofal, Michel Lecendreux, Stephen V. Faraone
Summary: This study examined the association between sleep disturbances and ADHD symptoms over a 9-year period, finding that sleep disturbances at age 13 predicted increased ADHD symptoms at age 18, while ADHD symptoms at age 9 predicted increased sleep disturbances at age 13. The findings highlight the importance of identifying these issues for preventive interventions.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Alessio Bellato, John Perna, Preethi S. Ganapathy, Marco Solmi, Andrea Zampieri, Samuele Cortese, Stephen Faraone
Summary: This study conducted a systematic review and meta-analysis to investigate the association between attention-deficit/hyperactivity disorder (ADHD) and eye disorders as well as altered visual function. The findings suggest that ADHD is associated with an increased risk of certain vision problems and visual function impairments, but not with structural changes in the eye.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Renee Kleine Deters, I. Hyun Ruisch, Stephen Faraone, Catharina A. Hartman, Marjolein Luman, Barbara Franke, Jaap Oosterlaan, Jan K. Buitelaar, Jilly Naaijen, Andrea Dietrich, Pieter J. Hoekstra
Summary: Genetic risk for antisocial and aggressive behaviors is related to amygdala shape alterations, indicating genetic sharing across different DBD and ASB and aggression-related phenotypes. Additionally, vertex-based shape analysis is useful in genetic studies of ASB, aggression, and DBDs.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Developmental
Yanli Zhang-James, Ali Shervin Razavi, Martine Hoogman, Barbara Franke, Stephen V. Faraone
Summary: This systematic review examines the literature on the development of magnetic resonance imaging (MRI)-based diagnostic classifiers for attention-deficit/hyperactivity disorder (ADHD) using machine learning (ML). It found variations in MRI modalities, ML models, cross-validation and testing methods, and sample sizes among the studies. The review also highlights the importance of large multi-modal imaging datasets and the potential combination with other types of data to develop clinically useful imaging classification tools for ADHD in the future.
JOURNAL OF ATTENTION DISORDERS
(2023)
Biographical-Item
Neurosciences
Stephen V. Faraone
BIOLOGICAL PSYCHIATRY
(2023)
Review
Clinical Neurology
Nevena V. Radonjic, Alessio Bellato, Nayla M. Khoury, Samuele Cortese, Stephen V. Faraone
Summary: This study conducted a systematic review and meta-analysis to assess the efficacy, acceptability, and tolerability of nonstimulants in adults with ADHD. The results showed that atomoxetine, guanfacine, and viloxazine ER were significantly more effective than placebo in treating ADHD. However, atomoxetine had poorer tolerability compared to placebo.
Article
Psychology, Developmental
Elisabeth F. Callen, Tarin L. Clay, Jillian Alai, David W. Goodman, Lenard A. Adler, Joel Shields, Stephen V. Faraone
Summary: This study aimed to assess the changes in quality care for adults with ADHD from 2010 to 2020. The results showed an increase in the achievement of quality measures over time, but none of the patients achieved more than six out of ten measures in any year. Small but significant effects were observed for sex, race, ethnicity, practice ownership, practice type, and age.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Endocrinology & Metabolism
Ali Zare Dehnavi, Yanli Zhang-James, Dan Draytsel, Ben Carguello, Stephen V. Faraone, Ruth S. Weinstock
Summary: This study found that approximately 49.2% of adults with type 2 diabetes (T2D) met the diagnostic criteria for attention-deficit/hyperactivity disorder (ADHD). However, there was no direct association between these symptoms and cardiovascular diseases or diabetic control. Further research is needed to clarify the relationship between ADHD symptoms, diabetic control, and comorbidities.
JOURNAL OF CLINICAL AND TRANSLATIONAL ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
John Perna, Alessio Bellato, Preethi S. Ganapathy, Marco Solmi, Andrea Zampieri, Stephen V. Faraone, Samuele Cortese
Summary: This study conducted a systematic review and meta-analysis to investigate the association between vision and/or eye disorders and Autism Spectrum Disorder (ASD). The findings suggest that ASD is associated with functional vision problems and structural alterations of the eye. However, further research is needed to clarify the causal relationship between ASD and vision problems.
MOLECULAR PSYCHIATRY
(2023)
Correction
Biochemistry & Molecular Biology
John Perna, Alessio Bellato, Preethi S. Ganapathy, Marco Solmi, Andrea Zampieri, Stephen V. Faraone, Samuele Cortese
MOLECULAR PSYCHIATRY
(2023)
Review
Pharmacology & Pharmacy
Lisa O'Connor, Stephanie Carbone, Anthony Gobbo, Hilary Gamble, Stephen Faraone
Summary: This article provides an overview of pharmacological treatment options for pediatric attention-deficit disorder (ADHD), including stimulant and non-stimulant medications. It offers detailed information on new medication options, such as anesthetic agents, extended-release forms, and novel adjunctive medications. These additions are beneficial for clinicians in their treatment toolbox.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)
