Article
Gastroenterology & Hepatology
David J. Hermel, Emma Z. Du, Ray Lin, Catherine T. Frenette, Darren S. Sigal
Summary: LEL-HCC is a rare liver tumor with potential efficacy and safety of immune checkpoint blockade, although current evidence-based practices are lacking. A case report demonstrates successful treatment of LEL-HCC with an immune checkpoint inhibitor. More robust, large-scale analysis is needed for better evaluation of treatment strategies and outcomes for this rare tumor subtype.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Oncology
Lan-Lan Pang, Jun Liao, Yi-Hua Huang, Jia-Di Gan, Wei-Tao Zhuang, Yi Lv, Wei-Ting Liang, Li Zhang, Wen-Feng Fang
Summary: Pulmonary lymphoepithelioma-like carcinoma (PLELC) is a rare and distinctive subtype of nonsmall cell lung cancer (NSCLC). The potential of immunotherapy for advanced PLELC, characterized by high PD-L1 expression and scarcity of druggable driver mutations, remains unclear due to limited and inconclusive evidence on the clinical impact of immune-checkpoint inhibitors (ICIs).
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Liming Li, Wenpeng Huang, Ping Hou, Weiwei Li, Menyun Feng, Yiyang Liu, Jianbo Gao
Summary: This study aimed to develop a preoperative risk scoring model based on CT images to distinguish lymphoepithelioma-like gastric carcinoma (LELGC) from non-LELGC. The study found that enhancement pattern, CT-defined lymph node status, and attenuation in the venous phase were independent predictors of LELGC. The risk identification model showed high accuracy in both the training and validation cohorts.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yi Xiao, Jinyuan He, Shaoning Luo, Min Dong, Wei Li, Gaijiao Liu, Hongjie Chen, Xiongwen Yang, Shaohong Huang
Summary: This study investigated the efficacy and safety of different treatment regimens for advanced pulmonary lymphoepithelioma-like carcinoma (pLELC). The results showed that chemoimmunotherapy had the highest 2-year progression-free survival (PFS) as a first-line treatment, suggesting that it may be the best treatment option for patients with advanced pLELC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Hong-Tao Tang, Wei Lin, Wei-Qiao Zhang, Jun-Lin Qian, Kai Li, Kun He
Summary: This is a case report of lymphoepithelioma-like carcinoma of the liver. A 38-year-old female patient was diagnosed with lymphoepithelial hepatocellular carcinoma after experiencing abdominal pain and nausea for three months. The patient underwent left hemihepatectomy and chemotherapy, and no tumor metastases were found during the 12-month follow-up. This case contributes to our overall understanding and treatment of this rare tumor.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Biochemistry & Molecular Biology
Bojiang Chen, Yu Zhang, Sisi Dai, Ping Zhou, Wenxin Luo, Zhoufeng Wang, Xuping Chen, Peng Cheng, Guoya Zheng, Jing Ren, Xiaodong Yang, Weimin Li
Summary: This study explored the genomic features of pLELC and compared them with other types of lung cancer. It was found that pLELC patients had better survival rates and high PD-L1 or p53 expression was associated with extended disease-free survival. pLELC had 14 frequently mutated genes and two miR-BARTs were discovered to potentially be involved in tumorigenesis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Oncology
Hui-Zhao Hong, Jia-Kang Li, Jia-Tao Zhang, Li-Shan Peng, Yi-Long Wu, Wen-Zhao Zhong
Summary: This study aimed to investigate the effects of neoadjuvant immunotherapy on pulmonary lymphoepithelioma-like carcinomas (LELC). The results showed that neoadjuvant immunotherapy was effective in treating LELC and demonstrated comparable efficacy with respect to different histological subtypes.
Article
Virology
Yan-Xia Wu, Wen-Li Zhang, Tong-Min Wang, Ying Liao, Yi-Jun Zhang, Ruo-Wen Xiao, Yi-Jing Jia, Zi-Yi Wu, Chang-Mi Deng, Da-Wei Yang, Wen-Qiong Xue, Yong-Qiao He, Xiao-Hui Zheng, Xi-Zhao Li, Ting Zhou, Pei-Fen Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Jiang-Bo Zhang, Wei-Hua Jia
Summary: This study provides the first comprehensive analysis of the genomic characteristics of Epstein-Barr virus (EBV) associated with pulmonary lymphoepithelioma-like carcinoma (PLELC). Through sequencing, the researchers identified 3,995 variations in EBV sequences from PLELC patients compared to a reference genome. They also discovered 32 significant variations associated with PLELC risk through a genome-wide association analysis. Additionally, they characterized the latent type-II infection of EBV in PLELC at both transcription and methylation levels.
JOURNAL OF VIROLOGY
(2022)
Article
Obstetrics & Gynecology
Asami Ikeda, Kaoru Abiko, Ikuko Emoto, Mari Ujita, Yumi Takao, Ikuo Konishi
Summary: Lymphoepithelioma-like carcinoma of the uterine cervix is a rare variant of squamous cell carcinoma. Preoperative diagnosis can be challenging, but magnetic resonance imaging findings are helpful in locating the tumor and guiding successful biopsy. Patients often present with postmenopausal bleeding and diverse tumor morphologies.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Respiratory System
Guiqin Chen, Qiane Yu, Haifeng Ran, XuHong Li, Tijiang Zhang
Summary: This article reports a rare case of cavitary lymphoepithelioma-like carcinoma of the lung and reviews the clinical and imaging characteristics reported in previous cases, which will be helpful for clinicians and imaging physicians in diagnosing this disease.
BMC PULMONARY MEDICINE
(2023)
Article
Oncology
Junjun Jia, Hongkai Guo, Jiabin Liu, Qi Sun, Guoqiang Cao, Shao Zhou, Mingqi Shuai, Feng Gao, Shusen Zheng, Min Zhang
Summary: The purpose of this study was to optimize the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma (LELC). By retrospectively analyzing 16 cases of LELC and using cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) as control groups, it was found that the diagnosis and treatment of LELC showed better results.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Immunology
Valtteri Kairaluoma, Niko Kemi, Heikki Huhta, Vesa-Matti Pohjanen, Olli Helminen
Summary: TLR5 expression is independently prognostic in HCC with a similar point estimate as previously known p53. High Ki67 and p53 expression are associated with 5-year overall- and disease-specific survival. Toll-like receptor 8 (TLR8) was not associated with patient survival in this study.
Article
Immunology
Wen-Qing Zou, Wei-Jie Luo, Yan-Fen Feng, Fang Liu, Shao-Bo Liang, Xue-Liang Fang, Ye-Lin Liang, Na Liu, Ya-Qin Wang, Yan-Ping Mao
Summary: In this study, the expression levels and prognostic value of multiple inhibitory checkpoints in head and neck lymphoepithelioma-like carcinoma (HNLELC) were investigated. The results showed that the expression of inhibitory checkpoints and an inhibitory checkpoint-based signature (ICS) may enhance the prognostic value of the TNM staging system and guide personalized inhibitory checkpoint blockade therapy in HNLELC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Zhou Sha, Yajun Wei, Tinghua Gao, Yuanling Luo, Jiaqun Chen, Ting Li, Liyang Hu, Xiaoli Niu, Zhong Lin, Weize Lv, Xiaofeng Pei
Summary: Pulmonary LELC typically occurs in non-smokers and is associated with EBV infection. Common treatments for the tumor include multimodal therapy. The expression of PD-L1 may be related to the prognosis of LELC.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yi-Jun Pan, Wei Liu, Qi-Xuan Qiu, Shou-Liang Miao, Meng-Su Zeng, Yan Shan, Jiang Lin, Peng-Ju Xu
Summary: This study compared the clinical and MRI features of primary hepatic lymphoepithelioma-like carcinoma (LELC) categorized as LR-M or LR-4/5 using LI-RADS version 2018 and identified prognostic factors for recurrence-free survival (RFS). The results showed that the LR-M category was an independent factor for RFS, with lower RFS rates in the LR-M group compared to the LR-4/5 group.
EUROPEAN RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Alka A. Potdar, Dalin Li, Talin Haritunians, Kelli L. VanDussen, Marie F. Fiorino, Ta-Chiang Liu, Thaddeus S. Stappenbeck, Phillip Fleshner, Stephan R. Targan, Dermot P. B. McGovern, Janine Bilsborough
JOURNAL OF CROHNS & COLITIS
(2019)
Article
Cell Biology
Gerard E. Kaiko, Feidi Chen, Chin-Wen Lai, I-Ling Chiang, Jacqueline Perrigoue, Aleksandar Stojmirovic, Katherine Li, Brian D. Muegge, Umang Jain, Kelli L. VanDussen, Bridie J. Goggins, Simon Keely, Jessica Weaver, Paul S. Foster, Daniel A. Lawrence, Ta-Chiang Liu, Thaddeus S. Stappenbeck
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Physiology
Nicole P. Malvin, Justin T. Kern, Ta-Chiang Liu, Steven L. Brody, Thaddeus S. Stappenbeck
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Yi Wang, I-Ling Chiang, Takahiro E. Ohara, Satoru Fujii, Jiye Cheng, Brian D. Muegge, Aaron Ver Heul, Nathan D. Han, Qiuhe Lu, Shanshan Xiong, Feidi Chen, Chin-Wen Lai, Hana Janova, Renee Wu, Charles E. Whitehurst, Kelli L. VanDussen, Ta-Chiang Liu, Jeffrey I. Gordon, L. David Sibley, Thaddeus S. Stappenbeck
Article
Infectious Diseases
Ta-Chiang Liu, Kelley VanBuskirk, Syed A. Ali, M. Paul Kelly, Lori R. Holtz, Omer H. Yilmaz, Kamran Sadiq, Najeeha Iqbal, Beatrice Amadi, Sana Syed, Tahmeed Ahmed, Sean Moore, I. Malick Ndao, Michael H. Isaacs, John D. Pfeifer, Hannah Atlas, Phillip Tarr, Donna M. Denno, Christopher A. Moskaluk
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Pathology
Rehan Rais, Jiani Chai, Elizabeth Blaney, Ta-Chiang Liu
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2020)
Article
Medicine, General & Internal
Lulu Sun, Jon N. Marsh, Matthew K. Matlock, Ling Chen, Joseph P. Gaut, Elizabeth M. Brunt, S. Joshua Swamidass, Ta-Chiang Liu
Article
Microbiology
Ta-Chiang Liu, Justin T. Kern, Umang Jain, Naomi M. Sonnek, Shanshan Xiong, Katherine F. Simpson, Kelli L. VanDussen, Emma S. Winkler, Talin Haritunians, Atika Malique, Qiuhe Lu, Yo Sasaki, Chad Storer, Michael S. Diamond, Richard D. Head, Dermot P. B. McGovern, Thaddeus S. Stappenbeck
Summary: Western diet can lead to dysfunction of Paneth cells and inhibit gut innate immunity. Obesity and high-fat diet may affect Paneth cells through microbiota and biological signaling pathways, contributing to diseases such as Crohn's disease.
CELL HOST & MICROBE
(2021)
Article
Gastroenterology & Hepatology
Shanshan Xiong, Charles E. Whitehurst, Li Li, Gyu Seong Heo, Chin-Wen Lai, Umang Jain, Brian D. Muegge, Scott T. Espenschied, Ryan J. Musich, Minhu Chen, Yongjian Liu, Ta-Chiang Liu, Thaddeus S. Stappenbeck
Summary: The study identified a transcriptional signature of mesenteric fibrosis in Crohn's disease patients and modeled a mouse model to simulate this condition. They found differentially expressed genes enriched in the mesenteric fat of CD subjects with high levels of fibrosis and identified a 24-gene set associated with inflammatory fibroblasts and treatment response.
Article
Immunology
Erika Feutz, Wieger Voskuijl, Peter J. Finch, Ta-Chiang Liu, Robert H. J. Bandsma, Phillip Tarr, Christopher Alan Moxon, Kelley VanBuskirk, Sarah Lawrence, Grace Umutesi, Kirkby D. Tickell, James A. Berkley, Judd L. Walson, Steve Kamiza, Donna M. Denno
Summary: This study demonstrates the feasibility of minimally invasive postmortem intestinal sampling in LMICs and its potential to identify histopathology related to mortality factors, such as duodenal cell depletion and chronic inflammation.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Matthew J. Wood, Jeffrey N. Marshall, Victoria L. Hartley, Ta-Chiang Liu, Kazuhiro Iwai, Thaddeus S. Stappenbeck, Donna A. MacDuff
Summary: Patients with mutations in HOIL1 may experience immune disorders including intestinal inflammation. This study found that HOIL1 plays a key role in regulating type 2 inflammation in the small intestine, affecting cell proliferation and gene expression. Commensal microbes may also contribute to intestinal inflammation.
MUCOSAL IMMUNOLOGY
(2022)
Article
Pediatrics
Lori R. Holtz, Julie Hoffmann, Laura Linneman, Mai He, Thomas C. Smyrk, Ta-Chiang Liu, Nurmohammad Shaikh, Cynthia Rodriguez, Roy B. Dyer, Ravinder J. Singh, William A. Faubion
Summary: This study aimed to explore the correlation between different measures of gut permeability and the severity of duodenal histopathology in children. The results showed that L:R was associated with biopsy evidence in children undergoing small bowel biopsy, while L:M was not. Despite increased intestinal permeability, there was scant evidence of systemic exposure to gut microbes in these children.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pathology
Marianna B. Ruzinova, Changqing Ma, Elizabeth M. Brunt, Charles W. Goss, Neeta Vachharajani, William C. Chapman, Ta-Chiang Liu
Summary: The expression of SOX9 is associated with poor prognosis in hepatocellular carcinoma and can be used as an independent prognostic factor.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Medicine, Research & Experimental
Saeed Soleymanjahi, Valerie Blanc, Elizabeth A. Molitor, David M. Alvarado, Yan Xie, Vered Gazit, Jeffrey W. Brown, Kathleen Byrnes, Ta-Chiang Liu, Jason C. Mills, Matthew A. Ciorba, Deborah C. Rubin, Nicholas O. Davidson
Summary: RNA-binding protein 47 (RBM47) plays an important role in embryonic endoderm development, and this study found that it also has implications in adult intestine function. Knockout mice lacking Rbm47 showed increased cell proliferation and abnormal morphology in the intestine, while Rbm47-deficient mice were protected against colitis-associated cancer. The findings suggest that RBM47 is a cell-intrinsic modifier of intestinal growth, inflammatory, and tumorigenic pathways.
Article
Multidisciplinary Sciences
Do-Hyun Kim, Yilin Wang, Haerin Jung, Rachael L. Field, Xinya Zhang, Ta-Chiang Liu, Changqing Ma, James S. Fraser, Jonathan R. Brestoff, Steven J. Van Dyken
Summary: This study describes a mammalian adaptation to dietary chitin through gastric immune activation and acidic mammalian chitinase, which facilitates chitin digestion. This adaptation is preserved in germ-free mice and leads to enhanced metabolic health and resistance to obesity.