Review
Orthopedics
Alan H. Daniels, Christopher L. McDonald, Bryce A. Basques, Eren O. Kuris
Summary: Ossification of the ligamentum flavum (OLF) is a spinal condition that can potentially cause compression of the spinal canal and neurological damage. The exact cause is debated but is likely related to gene overexpression and signaling pathways. Progressive myelopathy is the most common symptom, and radiographic analysis can show ossification in different areas. Surgical treatment options exist but may result in complications and postoperative neurological deficits.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Article
Surgery
Qiangqiang Pan, Zhenhui Zhang, Yanyu Zhu, Wentao Jiang, Kai Su, Peilin Liu, Yongsheng Kang, Zhe Shao, Wei Mei, Qingde Wang
Summary: This study proposed a zoning laminectomy to reduce the incidence of nerve injury during spinal surgery for thoracic ossification of the ligamentum flavum (TOLF). Retrospective analysis of 45 TOLF patients who underwent zoning laminectomy showed that it was a safe and effective surgical option.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Clinical Neurology
Qiangqiang Pan, Yanyu Zhu, Zhenhui Zhang, Wei Mei, Qingde Wang
Summary: This study retrospectively analyzed the imaging characteristics of patients with thoracic ossification of ligamentum flavum combined with dural ossification and the clinical efficacy of zoning laminectomy. The symptoms of all patients significantly improved after surgery, and the average mJOA score increased from 5.0 preoperatively to 8.7 postoperatively. The average improvement rate was 62.6%. The conclusion is that zoning laminectomy is safe and effective.
EUROPEAN SPINE JOURNAL
(2023)
Article
Medicine, General & Internal
Joohyun Kim, Woo-Keun Kwon, Hyunwook Cho, Subum Lee, Jang-Bo Lee, Jung-Yul Park, Dong Uk Jin, Eui Yub Jung, Junseok W. Hur
Summary: This study reveals that ligamentum flavum hypertrophy is an important factor in lumbar spinal canal stenosis and has a significant impact on clinical symptoms and outcomes compared to other components such as disc bulging and facet hypertrophy.
Article
Multidisciplinary Sciences
Kazuha Nakabachi, Tsutomu Endo, Masahiko Takahata, Ryo Fujita, Yoshinao Koike, Ryota Suzuki, Yuichi Hasegawa, Toshifumi Murakami, Katsuhisa Yamada, Hideki Sudo, Mohamad Alaa Terkawi, Ken Kadoya, Norimasa Iwasaki
Summary: Patients with lumbar ossification of the ligamentum flavum (OLF) may have a high risk of developing concomitant ossification of the entire spinal ligament, and the etiology is still unclear. This study investigated the propensity for spinal ligament ossification in asymptomatic individuals with lumbar OLF. The results showed that subjects with more lumbar OLF were more likely to have multilevel thoracic OLF and coexisting ossification of the posterior longitudinal ligament (OPLL).
SCIENTIFIC REPORTS
(2023)
Review
Clinical Neurology
Yoshinori Ishikawa, Naohisa Miyakoshi, Michio Hongo, Yuji Kasukawa, Daisuke Kudo, Chiaki Sato, Yoichi Shimada
Summary: This case report presents successful treatment of coexisting cervical OLF and OPLL in a 70-year-old male patient. Surgical intervention led to significant improvement in symptoms and maintenance of cervical alignment. Surgeons should carefully evaluate the severity of adhesion, muscle damage, and necessity of posterior corrective surgery, as well as consider the patient's comorbidities and potential postoperative complications.
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Venkata Vemula Ramesh Chandra, Bodapati C. M. Prasad, Paradesi Rajesh, Sudharsan Agarwal, Mohana Murali Krishna
Summary: This study identified age, associated trauma, OLF level, tuberous type OLF, intramedullary signal change on T2WI, preoperative severity of myelopathy, preoperative mJOA score, and Nurick grade as important predictors of surgical outcome in patients with T-OLF.
Article
Surgery
Canada T. Montgomery, Stephen P. Miranda, Ernest Nelson, Katie Louka, MacLean Nasrallah, Paul J. Zhang, Joel Stein, Dmitriy Petrov
Summary: This report discusses a rare case of spinal osteoblastoma with associated OLF and myelopathy. The patient's neurological symptoms completely resolved after surgical treatment, highlighting the effectiveness of surgery in such cases.
FRONTIERS IN SURGERY
(2022)
Article
Clinical Neurology
FuCheng Bian, Jian Zhang, GuangYu Bian, DaYong Wang, Bin Chen, YongSheng An
Summary: This study aimed to compare the short-term outcomes of PETD and PTL in treating thoracic ossification. The results showed that the PETD group had shorter operation time and less blood loss compared to the PTL group. The PETD group also had a higher recovery rate and fewer complications. In conclusion, PETD is an effective and feasible treatment option for thoracic ossification.
WORLD NEUROSURGERY
(2023)
Article
Multidisciplinary Sciences
Vuk Aleksic, Jovana Todorovic, Nenad Miladinovic, Nemanja Aleksic, Vojislav Bogosavljevic, Marko Durovic, Svetlana Kocic, Radmila Aleksic, Milos Jokovic
Summary: This observational cohort study examined the ligamentum flavum in patients with lumbar spinal stenosis (LSS) and lumbar disc herniation (LDH) to investigate the pathophysiology of neurogenic claudication. The thickening of ligamentum flavum in LSS patients was found to be the main cause of stenosis, and histological analysis revealed differences in the amount of collagen and elastic fibers between the groups. These findings support the inflammatory theory of spinal neurogenic claudication.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
Feng-Kai Yang, Peng-Fei Li, Chen-Tao Dou, Rong-Bo Yu, Bin Chen
Summary: In patients with thoracic spinal stenosis caused by ossification of the ligamentum flavum, both percutaneous endoscopic thoracic decompression (PETD) and posterior thoracic laminectomy (PTL) achieved favorable outcomes and safety. PETD is minimally invasive and achieves similar postoperative symptom relief to PTL, making it an effective alternative to traditional open surgery for thoracic ossification of the ligamentum flavum in a single-segment lower thoracic spine.
Article
Clinical Neurology
Hasibullah Habibi, Akinobu Suzuki, Kazunori Hayashi, Hamidullah Salimi, Hidetomi Terai, Yusuke Hori, Koji Tamai, Kumi Orita, Shoichiro Ohyama, Akito Yabu, Mohammad Hasib Maruf, Hiroaki Nakamura
Summary: This study revealed the upregulation of FGF9 in hypertrophied human LF, indicating its pivotal role in the hypertrophy process through cell proliferation and migration.
Article
Clinical Neurology
Jianwei Chen, Xiaosheng Yu, Manle Qiu, Fan Feng, Zude Liu, Guibin Zhong
Summary: This study identified differentially expressed circRNAs in hypertrophic ligamentum flavum (LFH) compared to nonhypertrophic tissues in lumbar spinal stenosis patients. Specifically, hsa_circ_0052318 was shown to play a significant role in the pathogenesis of LF hypertrophy.
Article
Orthopedics
Tsuyoshi Yamada, Shigeo Shindo, Toshitaka Yoshii, Shuta Ushio, Kazuo Kusano, Norihiko Miyake, Yoshiyasu Arai, Kazuyuki Otani, Atsushi Okawa, Osamu Nakai
Summary: This study evaluated the prevalence, distribution, and clinical characteristics of thoracic ossification of ligamentum flavum (T-OLF) in patients with lumbar spinal canal stenosis (LCS). The findings indicated that T-OLF was highly associated with other spinal disorders, and poor outcomes in T-OLF surgery could be due to age and concurrent LCS. Additional lumbar surgery effectively improved neurological findings in T-OLF patients with LCS.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Clinical Neurology
Fumio Hayashi, Masatoshi Morimoto, Kosaku Higashino, Yuichiro Goda, Nori Sato, Fumitake Tezuka, Kazuta Yamashita, Koichi Sairyo
Summary: This study reveals for the first time that myofibroblast expression levels are higher in the dorsal layer of the ligamentum flavum (LF) than in the dural layer. It confirms that hypertrophy of the LF in lumbar spinal canal stenosis is associated with increased expression of myofibroblasts in the dorsal layer. Hypoxia could be a cause of myofibroblast expression leading to fibrosis and ultimately to hypertrophy of the LF.
Article
Clinical Neurology
Itaru Yugue, Seiji Okada, Muneaki Masuda, Takayoshi Ueta, Takeshi Maeda, Keiichiro Shiba
EUROPEAN SPINE JOURNAL
(2016)
Article
Clinical Neurology
T. Takao, K. Kubota, T. Maeda, S. Okada, Y. Morishita, E. Mori, I. Yugue, O. Kawano, H. Sakai, T. Ueta, K. Shiba
Article
Clinical Neurology
Hirofumi Bekki, Katsumi Harimaya, Yoshihiro Matsumoto, Mitsumasa Hayashida, Seiji Okada, Toshio Doi, Yukihide Iwamoto
Article
Clinical Neurology
Yoshihiro Matsumoto, Katsumi Harimaya, Kenichi Kawaguchi, Mitsumasa Hayashida, Seiji Okada, Toshio Doi, Yukihide Iwamoto
Article
Clinical Neurology
Itaru Yugue, Seiji Okada, Muneaki Masuda, Takayoshi Ueta, Takeshi Maeda, Keiichiro Shiba
Article
Clinical Neurology
Seiji Okada, Charles Chang, Geraldine Chang, James J. Yue
Article
Orthopedics
Hirokazu Saiwai, Seiji Okada, Kosei Miyazaki, Ryuji Nakano, Yukihide Iwamoto, Kuniyoshi Tsuchiya
JOURNAL OF ORTHOPAEDIC SCIENCE
(2017)
Article
Multidisciplinary Sciences
Nobuhiko Yokoyama, Tomoya Matsunobu, Yoshihiro Matsumoto, Jun-ichi Fukushi, Makoto Endo, Mihoko Hatano, Akira Nabeshima, Suguru Fukushima, Seiji Okada, Yukihide Iwamoto
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Takeyuki Saito, Kazuya Yokota, Kazu Kobayakawa, Masamitsu Hara, Kensuke Kubota, Katsumi Harimaya, Kenichi Kawaguchi, Mitsumasa Hayashida, Yoshihiro Matsumoto, Toshio Doi, Keiichiro Shiba, Yasuharu Nakashima, Seiji Okada
Article
Clinical Neurology
Shingo Yoshizaki, Kazuya Yokota, Kensuke Kubota, Takeyuki Saito, Masatake Tanaka, Dai-jiro Konno, Takeshi Maeda, Yoshihiro Matsumoto, Yasuharu Nakashima, Seiji Okada
Article
Orthopedics
Satoshi Miyamura, Ryoya Shiode, Jonathan Lans, Kunihiro Oka, Hiroyuki Tanaka, Seiji Okada, Tsuyoshi Murase, Neal C. Chen
Summary: In scaphoid nonunion advanced collapse (SNAC) wrist arthritis, unique deformity patterns and alterations in bone-density distributions were observed. The distal carpal row shifted dorsally, migrated proximally, pronated, deviated ulnarly, and shifted radially, with greater bone density at specific joints in the nonunion group compared with the control group.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Cell & Tissue Engineering
K. Uemura, Y. Otake, K. Takashima, H. Hamada, T. Imagama, M. Takao, T. Sakai, Y. Sato, S. Okada, N. Sugano
Summary: This study developed and validated a fully automated system for quantifying proximal femoral bone mineral density (BMD) from CT images. The system showed accurate measurements of DXA-BMD and diagnosis of osteoporosis using open-source models.
BONE & JOINT RESEARCH
(2023)
Article
Cell & Tissue Engineering
Shinichi Nakagawa, Wataru Ando, Kazunori Shimomura, David A. Hart, Hiroto Hanai, George Jacob, Ryota Chijimatsu, Seido Yarimitu, Hiromichi Fujie, Seiji Okada, Noriyuki Tsumaki, Norimasa Nakamura
Summary: Hybrid implants containing both human mesenchymal stromal cells (MSC) and induced pluripotent stem cells (iPSC) have the potential to enhance the repair of osteochondral defects. The tissue engineered constructs (TEC) component of these implants plays a critical role in defect filling, integration, angiogenesis, and neovascularization.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Pathology
Kazuya Yokota, Kazu Kobayakawa, Takeyuki Saito, Masamitsu Hara, Ken Kijima, Yasuyuki Ohkawa, Akihito Harada, Ken Okazaki, Kohei Ishihara, Shigeo Yoshida, Akira Kudo, Yukihide Iwamoto, Seiji Okada
AMERICAN JOURNAL OF PATHOLOGY
(2017)
Article
Orthopedics
Tsuneaki Takao, Seiji Okada, Yuichiro Morishita, Takeshi Maeda, Kensuke Kubota, Ryosuke Ideta, Eiji Mori, Itaru Yugue, Osamu Kawano, Hiroaki Sakai, Takayoshi Ueta, Keiichiro Shiba
ASIAN SPINE JOURNAL
(2016)